Botswana Tenofovir Oral HIV Prophylaxis Trial
HIV Infection
About this trial
This is an interventional prevention trial for HIV Infection focused on measuring HIV incidence, HIV prevention
Eligibility Criteria
Inclusion Criteria: citizen of Botswana 18-29 years old sexually active HIV uninfected Hepatitis B and C uninfected Calculated creatinine clearance >= 60 mL/min hemoglobin >= 8 gm/dL ALT and AST <= 2x ULN total bilirubin <= 1.5 mg/dL total serum amylase <= 1.5x ULN Serum phosphorus >= 2.2 mg/dL willing to use effective contraception living within 1 hours travel of study clinic pass comprehension test willing and able to give informed consent Exclusion Criteria: history of significant renal or bone disease any chronic illness requiring ongoing prescription medication pregnant or breastfeeding planning to move away from site in the next year participating in another HIV prevention or vaccine safety trial any other clinical condition or prior therapy that, in the opinion of the study physician, would make the volunteer unsuitable for the study or unable to comply with the dosing requirements
Sites / Locations
- Centers for Disease Control and Prevention
- BOTUSA HIV Prevention Research Unit