Brain Connectivity as a Biomarker of Response to Transcranial Stimulation by Continuous Current in Patients With Stroke
Stroke
About this trial
This is an interventional treatment trial for Stroke focused on measuring Stroke, Transcranial direct current stimulation, Functional Connectivity, Motor function, Quality of life
Eligibility Criteria
Inclusion Criteria:
- Have had a single episode of unilateral, ischemic stroke, in middle cerebral artery proven by means of magnetic resonance imaging or computed tomography;
- Young adult individuals, over 18 years old;
- Both sexes;
- Patients in late subacute stage. Late sub-acute stage will be considered for patients between 3 and 6 months after stroke;
- Mild to moderate patients with a Fugl-Meyer score >85 points;
- Patients with mild to moderate degree of injury severity (NIHHS <17 points);
- Presentation of up to 4 points on the Rankin scale.
Exclusion Criteria:
- Use of drugs that modulate the activity of the Central Nervous System;
- Carriers of implanted metallic or electronic devices; cardiac pacemaker;
- habitual use of drugs or alcohol;
- Epilepsy history report; gestation; people with traumatic brain injury or tumors.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
active tDCS
Sham tDCS
Participants will receive 10 ETCC sessions, for 20 minutes, on alternate days (3 times a week). The electrodes will be positioned on the primary motor cortex (position C3 or C4 according to the international electroencephalogram system - EEG 10/20), with the anode positioned on the affected hemisphere and the cathode on the supraorbital region in the hemisphere contralateral to the injury. The electrodes will be wrapped with sponges of 5 x 7 cm and moistened with saline (NaCl 0.9%). The current intensity will be 2mA.
The protocol for placebo stimulation will be identical, but the device will stop emitting current 30 seconds after the start of stimulation.