Brain Function in Focal Dystonia
Dystonia
About this trial
This is an observational trial for Dystonia focused on measuring Learning, PAS, Upper Limb, TMS, Somatosensory, Dystonia, Upper Limb Dystonia, Healthy Volunteer, HV
Eligibility Criteria
INCLUSION CRITERIA: Healthy volunteers (aged 18 or older) who are willing to participate. Patients (aged 18 and older) with an idiopathic upper limb dystonia, who are able to practice the motor learning task. EXCLUSION CRITERIA: Subjects with a history of neurological or psychiatric disorder, current use or a history of alcohol or drug abuse, psychiatric disorders requiring hospitalization or prolonged treatment such as substance abuser addiction, head injury with loss of consciousness, epilepsy. Subjects with significant hearing loss. Subjects receiving drugs acting primarily on the central nervous system. Subjects who have been treated with botulinum toxin injections 3 months prior to their participation in the study. Subjects who are taking any medication for dystonia at the time of the study. Subjects who have already participated in a protocol using a motor learning task. Subjects who practice intensively playing any kind of music instrument. The following exclusion criteria are due to the use of transcranial magnetic stimulation: Subjects with cardiac pacemakers, intracardiac lines, implanted medication pumps. Subjects with eye, blood vessel, cochlear, or eye implants. Subjects with increased intracranial pressure as evaluated by clinical means. Subjects with metal in the cranium. Subjects with dental braces (but dental fillings are not a problem), metal fragments from occupational exposure or surgical clips in or near the brain. Women in the last trimester of pregnancy will not be studied because they will likely be uncomfortable maintaining a motionless seated posture during the three hour experiment.
Sites / Locations
- National Institutes of Health Clinical Center, 9000 Rockville Pike