Breaks in Sedentary Time and Glucose Regulation in Women (ACUTE)
Impaired Glucose Tolerance
About this trial
This is an interventional prevention trial for Impaired Glucose Tolerance
Eligibility Criteria
Inclusion Criteria:
- Sedentary
- Overweight or obese (BMI>25kg/m2)
- Post menopausal
- Previous diagnosis of impaired glucose tolerance
Exclusion Criteria:
- Regular purposeful exercise (≥150 minutes of MVPA per week)
- Physical condition which limits full participation in the study
- Active psychotic illness or other significant illness which, in the view of the investigators, would prevent full participation
- Inability to communicate in spoken English
- Steroid use
- Known Type 2 Diabetes
- Pregnancy
- Male
- Currently taking hormone replacement medication.
Sites / Locations
- Leicester Diabetes Centre, Leicester General Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Sitting
Standing
Walking
During the sitting treatment condition, walking and standing will be restricted. Participants will be in a designated room with access to a computer, books/magazines throughout the day. Participants will have a cannula fitted and the first of the half-hourly blood samples will be taken (time point: -1hr). Participants will then be asked to sit quietly for 60 minutes to achieve a steady state. Following this, participants will have another blood sample taken and then be provided with a standardised mixed meal breakfast (09:00am) (time point: 0h). Blood sampling will continue at 30 minutes intervals for 3 hours following breakfast. A second, lunch meal (12:00pm), will be then be consumed over 15 minutes. Blood sampling will then continue at 30 minute intervals for 3 hours following lunch.
This is the same as the sitting condition, but participants will be asked to break their sitting time by standing close to their chair for 5 minutes, after 15 and 45 minutes of each hour following breakfast. The standing protocol will be repeated after lunch. Individuals will be asked to stand in the same position with no further instructions provided. In total, individuals will accumulate 12 bouts (60 minutes) of standing throughout the test period.
This is identical to the standing condition, but the breaks in sitting time will be punctuated with 5 minute bouts of light-intensity treadmill walking (equivalent to around 4.0km•h-1) rather than standing. In total, individuals will accumulate 12 bouts (60 minutes) of light-intensity activity throughout the test period. The light-intensity walking activity undertaken here replicates the low-grade ambulatory activity associated with everyday life.