Bupropion as a Smoking Cessation Aid in Alcoholics

Inclusion Criteria: Currently a patient in the Omaha VA Medical Center, Substance Abuse Treatment Center (SATC) or at Catholic Charities Campus for Hope. Have a diagnosis of alcohol abuse or alcohol dependence. Smoke 20 or more cigarettes/day (may also smoke pipes/cigars). Be interested in quitting smoking. Provide name, addresses, and phone numbers of at least two individuals who can provide information on their alcohol, nicotine, and other drug use during the follow-up period. If female, patient must a) be of non-childbearing potential, b) have a negative pregnancy test, c) sign a document stating they do not plan on becoming pregnant during the study. Agree to sign informed consent. Able to read and understand study-related forms and procedures. Exclusion Criteria: Advanced cardiac, pulmonary, renal, or liver disease. History of seizures. History of brain tumor or significant head trauma. History of bulimia or anorexia nervosa. Current major depressive disorder or past history of panic disorders, schizophrenia, or bipolar affective disorder. Using psychoactive drugs. Receiving treatment with medications that lower seizure thresholds. Use of an investigational drug in any study in the past four weeks. Currently using any asthma medication. Used time-released bupropion in the past 12 months. Currently using any other treatments to stop smoking.