Ca-hydroxyapatite, Fluoroapatite, and Mg-Zn-hydroxyapatite for Dentin Hypersensitivity Management
Dentin Hypersensitivity
About this trial
This is an interventional treatment trial for Dentin Hypersensitivity focused on measuring dentin sensitivity, tooth abrasion, Ca-hydroxyapatite, fluoroapatite, Mg-Zn-hydroxyapatite
Eligibility Criteria
Inclusion Criteria:
- aged between 35 and 45 years
- signed an approved Informed Consent Form, authorizing the participation in the trial and the use of the results of the trial for educational purposes and for the publication
- the diagnosis of dentin hypersensitivity stated clinically
- a premolar or first molar with an abrasive cervical defect of at least 1 millimeter, and not deeper than 1.5 millimeter, as measured by placing a periodontal probe into the deepest part of the cervical lesion; no mesial, distal or buccal restorations (to avoid confounding hypersensitivity)
- a hypersensitivity score of 2 or higher on the Shiff scale with standardized air-blast stimulation
- no other tooth in the same quadrant exhibiting hypersensitivity
Exclusion Criteria:
- medical and pharmacotherapeutic histories that may compromise the protocol (pregnancy or breastfeeding, allergies to toothpastes ingredients, eating disorders)
- systemic conditions that are etiologic to dentin hypersensitivity (e.g., chronic acid regurgitation)
- excessive dietary or environmental exposure to acids
- periodontal surgery in the preceding 3 months
- orthodontic appliance treatment within previous 3 months
- teeth or supporting structures with any other painful pathology or defects
- teeth restored in the preceding 3 months
- abutment teeth for fixed or removable prostheses
- extensively restored teeth and those with restorations extending into the test area.
Sites / Locations
- Institute of Dentistry of Sechenov University
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
Experimental
Group 1 - HAP-containing toothpaste
Group 2 - Zn Mg HAP-containing toothpaste
Group 3 - FAP-containing toothpaste
The use of HAP-containing toothpaste twice daily (using standardised toothbrushing technique) for 4 weeks. Toothpaste composition: Aqua, Sorbitol, Hydrated Silica, Glycerin, Hydroxyapatite, Cellulose Gum, Sodium Myristoyl Sarcosinate, Sodium Methyl Cocoyl Taurate, Aroma, Xanthan Gum, Stevia Rebaudiana Extract, Anethole, Tetrasodium Glutamate Diacetate, Tocopheryl Acetate, Eucalyptol, o-Cymen-5-ol, Citric Acid, Vitis Vinifera (Grape) Seed Extract, Tannase, Thymol, Limonene. Fluoride free.
The use of Zn Mg HAP-containing toothpaste twice daily (using standardised toothbrushing technique) for 4 weeks. Toothpaste composition: Aqua, Sorbitol, Hydrated Silica, Glycerin, Zn-Mg-hydroxyapatite, Cellulose Gum, Sodium Myristoyl Sarcosinate, Sodium Methyl Cocoyl Taurate, Aroma, Xanthan Gum, Stevia Rebaudiana Extract, Anethole, Tetrasodium Glutamate Diacetate, Tocopheryl Acetate, Eucalyptol, o-Cymen-5-ol, Citric Acid, Vitis Vinifera (Grape) Seed Extract, Tannase, Thymol, Limonene. Fluoride free.
The use of FAP-containing toothpaste twice daily (using standardised toothbrushing technique) for 4 weeks. Toothpaste composition: Aqua, Sorbitol, Hydrated Silica, Glycerin, Fluorapatite, Cellulose Gum, Sodium Myristoyl Sarcosinate, Sodium Methyl Cocoyl Taurate, Aroma, Xanthan Gum, Stevia Rebaudiana Extract, Anethole, Tetrasodium Glutamate Diacetate, Tocopheryl Acetate, Eucalyptol, o-Cymen-5-ol, Citric Acid, Vitis Vinifera (Grape) Seed Extract, Tannase, Thymol, Limonene.