Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia (EPhON)
Cardiac Output, Low
About this trial
This is an interventional treatment trial for Cardiac Output, Low focused on measuring Spinal anesthesia, cardiac output, vasopressor
Eligibility Criteria
Inclusion Criteria:
- ASA I / II
- Caesarean section, non-twinned
Exclusion Criteria:
- heart disease
- HTA
- non-gestational diabetes
- pre-eclampsia
- sepsis
- BMI greater than 40
- contraindication to spinal anesthesia: patient refusal, medicinal allergy, long QT syndrome.
Sites / Locations
- Tunis maternity and neonatology center, minisetry of public health
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Active Comparator
Active Comparator
ephedrine
phenylephrine
ondansetron
norepinephrine
will receive ephedrine :a bolus of 9 mg after SA once intervention: will receive complementary doses of ephedrine 6 mgto maintain systolic blood pressure above 80 % of baseline
will receive Phenylephrine : a bolus of 100 mcg once intervention: will receive complementary doses of ephedrine 6 mg to maintain systolic blood pressure above 80 % of baseline
will receive ondansetron: a bolus of 8 mg once intervention: will receive complementary doses of ephedrine 6 mg to maintain systolic blood pressure above 80 % of baseline
will receive noradrenaline (norepinephrine) a bolus of 0,25 mcg/kg once intervention: will receive complementary doses of ephedrine 6 mg to maintain systolic blood pressure above 80 % of baseline