Cardio-respiratory Responses During Hypoxic Exercise in Individuals Born Prematurely (PreTerm)
Hypoxia, Altitude Sickness, Tolerance
About this trial
This is an interventional prevention trial for Hypoxia
Eligibility Criteria
Inclusion Criteria:
Healthy male individuals
PRETERM group; gestational age: ≤ 32 weeks; gestational weight ≤ 1500 g
CONTROL group: full term born individuals ≤ 38 weeks
Exclusion Criteria:
Medication required that may interfere with the interpretation of the results
Chronically illnesses
Hormonal therapy
Recent sub-standard nutritional status
Family history of respiratiory, cardio-vascular, renal or hematological disease History of: thyroid dysfunction, renal stones, diabetes, allergies, hypertension, hypocalcaemia, uric acidaemia, lipidaemia or hyperhomocystinaemia
History of mental illness
Smoker within six months prior to the start of the study
Abuse of drugs, medicine or alcohol
Participation in another study up to two months before study onset
No signed consent form before the onset of the experiment
Blood donors in the past three months before the onset of the experiment
Vegetarian and Vegans
Migraines
History of vestibular disorders
Claustrophobia
Sites / Locations
- Jozef Stefan InstituteRecruiting
- University Children's Hospital Ljubljana Department of Pediatric NeurologyRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Hypoxia at rest and exercise
Normoxia at rest and exercise
The participants will perform a resting test, hypoxia sensitivity test and a graded exercise test to voluntary exhaustion in normoxic condition ((HYPO; FiO2=0.120 corresponding to terrestrial altitude of approx. 4000 m)
The participants will perform a resting test and a graded exercise test to voluntary exhaustion in normoxic condition ((NORM; fraction of inspired oxygen (FiO2)=0.209, placebo)