CardioPulmonary Resuscitation With Argon (CPAr) Trial (CPAr)
Cardiac Arrest, Out-Of-Hospital, Cardiac Arrest With Successful Resuscitation
About this trial
This is an interventional treatment trial for Cardiac Arrest, Out-Of-Hospital focused on measuring Cardiac arrest; Cardiopulmonary resuscitation; Argon.
Eligibility Criteria
Inclusion Criteria:
ICU admission after resuscitation from witnessed non-traumatic out-of-hospital cardiac arrest (OHCA) of presumably cardiac etiology with a presenting shockable rhythm; age ≥ 18 years; unconsciousness after return of spontaneous circulation (ROSC); duration of CPR ≤ 30 mins; initiation of study intervention ≤ 3 hrs from ROSC; stable SaO2 ≥ 94% with a FiO2 of 30%.
Exclusion Criteria:
Non-witnessed CA; CA of traumatic origin or from a non-presumably cardiac cause; CA with a non-shockable presenting rhythm (pulseless electrical activity and asystole); female of childbearing potential defined as younger of 50 years; pregnancy; known terminal illness; pre-CA cerebral performance category (CPC) ≥ 3; initiation of the study intervention > 3 hrs from ROSC: participation to another clinical trial.
Sites / Locations
- Ospedale San Gerado
- Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Intervention
Control-standard
Patients will be ventilated with a mixture of Ar 70%/O2 30% for 4 hours
Ventilation with a FiO2 of 30% in room air is continued for 4 hours.