Catheter Thrombectomy in Patients With Massive Pulmonary Embolism
Pulmonary Embolism
About this trial
This is an interventional treatment trial for Pulmonary Embolism focused on measuring Massive pulmonary embolism, Catheter thrombectomy
Eligibility Criteria
Inclusion Criteria: Patients >= 18 years of age with pulmonary embolism and cardiogenic shock, defined as a systolic arterial pressure <= 90 mmHg, a drop in systolic arterial pressure >= 40 mmHg for >= 15 minutes, or ongoing administration of catecholamines for systemic arterial hypotension Subtotal or total filling defect in the left and/or right main pulmonary artery due to massive PE, as assessed by chest computed tomography or by conventional pulmonary angiography Right ventricular dysfunction on echocardiography: RV systolic hypokinesis and/or RV dilation (optional) Failed thrombolysis or at least one of the following contraindications to PE thrombolysis present: Active bleeding History of intracranial bleeding Surgery, delivery, organ biopsy, puncture of a non-compressible vessel within 10 days History of stroke Gastrointestinal bleeding within 10 days Significant trauma within 15 days Head injury requiring hospitalization within 1 year Active cancer with known hemorrhagic risk Neurosurgery or ophthalmologic surgery within the past year Platelets < 50,000 or INR >2.0 Pregnancy Exclusion Criteria Systemic (paradoxical) embolism in the presence of an atrial septal defect or patent foramen ovale Free floating right heart thrombi, left heart thrombi Life expectancy due to underlying disease less than one month
Sites / Locations
- Herz-Gefässklinik Bad Neustadt
- Klinik für Diagnostische Radiologie Christian-Albrechts-Universität Kiel
- Universität Leipzig Herzzentrum
- Otto-von-Guericke-Universität Magdeburg
- Kantonsspital Luzern