CD8 DLI for Patients With Relapse or Residual Disease Following Allogeneic Stem Cell Transplantation

Patients of any age who have previously undergone allogeneic hematopoietic transplantation and have evidence of donor cell engraftment (>20% donor cell within three months of study entry) Expected survival >4 weeks CML patients with molecular, cytogenetic or hematologic relapse following allogeneic transplantation Molecular relapse- patients are eligible if bcr/abl is detectable at any time after day 180 post-allogeneic transplantation or if a negative bcr/abl PCR test was documented post-transplantation and the bcr/abl test is now positive by consecutive PCR determinations at least 4 weeks apart. Cytogenetic relapse-patients are eligible if standard cytogenetics demonstrate >10% t (9,22) positive cells greater than 60 days after myeloablative transplantation or 10% t (9,22) positive cells greater than 100 days after nonmyeloablative transplantation. CML patients with accelerated phase or blast crisis following allogeneic transplantation Patients with CLL, NHL, MM, or HD who have evidence of disease relapse or persistent disease at 60 days post-allo BMT and/or: MM- patients with a rising M-protein is detectable at 180 days post-transplant NHL - patients with molecular evidence of disease (bcl-2, t (4,11), etc.) at 180 days post transplant CLL, NHL or HD - patients with clear cut evidence of tumor growth at any time post-transplant are eligible Patients undergoing an HLA -identical or 5/6 antigen match transplant from a related or unrelated donor Patient's original donor must be available for lymphocyte donation There must be no evidence of active acute or graft-versus-host disease and patients should be off all immunosuppressive agents for, at least, two weeks prior to DLI. Patients on stable dose of methylprednisolone (<16 mg/d) without evidence of active GVHD are also eligible. Patients must have a Zubrod PS<2 (see appendix 7), Cr<2.5, bilirubin <3, and transaminases (SGPT, SGOT) <4x normal Patient must be able to sign informed consent