Celebrex for Pain Relief After Oral Surgery
Facial Pain
About this trial
This is an interventional treatment trial for Facial Pain focused on measuring Celecoxib, Thromboxane B2, Prostaglandin E2, Microdialysis, Ibuprofen
Eligibility Criteria
INCLUSION CRITERIA: Healthy volunteers between the ages of 18-65 years. Patients will be eligible for this study if the two mandibular molars are classified as partial or full bony impactions. EXCLUSION CRITERIA: Patients who are allergic to sulfa-drugs. Patients who have had asthma, hives or an allergic reaction to aspirin, ibuprofen or any similar drugs. Patients with gastrointestinal ulcers or a history of gastrointestinal bleeding. Patients who are pregnant or nursing. Patients of infection or inflammation [pericoronitis] at either extraction site. Patients with severe kidney disease. Patients who are taking any of the following drugs: anti-depressants, diuretics, aspirin on a near daily basis, coumadin or other blood thinners. Patients who are taking drugs known to inhibit P450 2C9 and drugs metabolized by P450 2D6.
Sites / Locations
- National Institute of Dental And Craniofacial Research (NIDCR)