Cell Therapy in Chagas Cardiomyopathy

Inclusion Criteria: Diagnosis of dilated cardiomyopathy according to WHO criteria Syndromic heart failure in functional class III or IV of the NYHA Enrollment and continuous follow-up in cardiac out-patient clinic Adequate medical therapy after optimization therapy Echocardiogram with an ejection fraction equal to or less than 35% by Simpson's rule Exclusion Criteria: Valvular diseases, except functional mitral or tricuspid reflow Coronariography showing a significant lesion (obstruction of at least 50% of the lumen in the troncus or the main arteries - LAD, CX, RC) in one or more arteries Serologic diagnosis for Chagas disease or at least two of the following criteria: epidemiology, right bundle branch block, anterior hemi-block, apical aneurism Sustained ventricular tachycardia Abusive use of alcohol or illicit drugs Pregnancy Use of cardio toxic drugs Any co-morbidity with impact in life expectancy in 2 years Renal function compromised (creatinine above 2 mg/dl) Definitive implant of pace-makers, resynchronizers and CDIs Heart failure with symptoms initiating less than 1 year ago Active systemic arterial hypertension or history of hypertension