Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
Obstructive Sleep Apnea of Adult, Hypoxia, Brain, Sleep Apnea
About this trial
This is an interventional basic science trial for Obstructive Sleep Apnea of Adult
Eligibility Criteria
Inclusion Criteria:
- Healthy adults
- 18 - 45 years of age
- Living in Calgary for the past one year
- Have no medical condition or should not be taking any blood pressure medications.
- The participant should not be lactose intolerant
Exclusion Criteria:
- Cerebrovascular, cardio-respiratory, renal and metabolic diseases
- Bleeding disorders and upper gastrointestinal diseases e.g. peptic ulcer disease
- Pregnancy, obese and sleep-disordered breathing
- Drug allergies to non-steroidal anti-inflammatories
- Currently smoking
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Experimental
Sham Comparator
Placebo Comparator
CBF Lowering and Normoxia Sleep
CBF Lowering and IH Sleep
Placebo and Normoxia Sleep
Placebo and IH Sleep
Study participants will take drug lowering Cerebral Blood Flow (CBF) and sleep under room air i.e. normoxia exposure.
Study participants will take drug lowering Cerebral Blood Flow (CBF) and sleep under Intermittent Hypoxia (IH) exposure.
Study participants will take Placebo that has no effect on Cerebral Blood Flow (CBF) and sleep under room air i.e. normoxia exposure.
Study participants will take Placebo that has no effect on Cerebral Blood Flow (CBF) and sleep under Intermittent Hypoxia (IH) exposure.