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Change of Neural Network Indicators Through Narrative Treatment of PTSD in Torture Victims

Primary Purpose

PTSD

Status
Unknown status
Phase
Not Applicable
Locations
Germany
Study Type
Interventional
Intervention
NET
Sponsored by
University of Konstanz
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for PTSD focused on measuring PTSD, torture survivors, Narrative Exposure Therapy, trauma-related memory processes, steady state visual evoked fields

Eligibility Criteria

18 Years - 65 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • experiences of organized violence/torture
  • PTSD diagnosis

Exclusion Criteria:

  • psychotic disorder
  • neurological disease or seizures
  • current drug/alcohol abuse

Sites / Locations

  • University of Konstanz, Department of Psychology

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

No Intervention

Arm Label

A

B

Arm Description

Narrative Exposure Therapy (NET)

Waitinglist Control Group

Outcomes

Primary Outcome Measures

PTSD diagnosis and severity score according to the Clinicians Administered PTSD Scale (CAPS)

Secondary Outcome Measures

steady state visual evoked magnetic fields in response to affective stimuli

Full Information

First Posted
November 23, 2007
Last Updated
November 23, 2007
Sponsor
University of Konstanz
Collaborators
German Research Foundation
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1. Study Identification

Unique Protocol Identification Number
NCT00563888
Brief Title
Change of Neural Network Indicators Through Narrative Treatment of PTSD in Torture Victims
Official Title
Change of Neural Network Indicators Through Narrative Treatment of PTSD in Torture Victims
Study Type
Interventional

2. Study Status

Record Verification Date
November 2007
Overall Recruitment Status
Unknown status
Study Start Date
January 2007 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
December 2008 (Anticipated)

3. Sponsor/Collaborators

Name of the Sponsor
University of Konstanz
Collaborators
German Research Foundation

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
Effective Treatment of PTSD involves talking about the traumatic event in detail.It is unclear how this process influences the sensory-specific trauma network (fear structure)in the traumatized person. The goal of the project is to test the hypothesis that treatment-facilitated recovery does not change the original fear structure but establishes an inhibitory mechanism that depends on verbal activity. An affective visual steady-state paradigm in magnetencephalography (MEG) using positive, aversive and neutral picture stimuli will be used to examine the spatial and temporal pattern of the processing of emotional stimuli. To examine the effects of treatment this paradigm will be used as outcome measure within a randomized controlled trial of Narrative Exposure Therapy and a waiting-list control condition for severely traumatized torture victims.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
PTSD
Keywords
PTSD, torture survivors, Narrative Exposure Therapy, trauma-related memory processes, steady state visual evoked fields

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Outcomes Assessor
Allocation
Randomized
Enrollment
30 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
A
Arm Type
Experimental
Arm Description
Narrative Exposure Therapy (NET)
Arm Title
B
Arm Type
No Intervention
Arm Description
Waitinglist Control Group
Intervention Type
Behavioral
Intervention Name(s)
NET
Intervention Description
Narrative Exposure Therapy for traumatized survivors of organized violence
Primary Outcome Measure Information:
Title
PTSD diagnosis and severity score according to the Clinicians Administered PTSD Scale (CAPS)
Time Frame
4 & 9 months after completion of treatment
Secondary Outcome Measure Information:
Title
steady state visual evoked magnetic fields in response to affective stimuli
Time Frame
4 & 9 months after completion of treatment

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: experiences of organized violence/torture PTSD diagnosis Exclusion Criteria: psychotic disorder neurological disease or seizures current drug/alcohol abuse
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Claudia Catani, Dr.
Organizational Affiliation
University of Konstanz
Official's Role
Study Director
First Name & Middle Initial & Last Name & Degree
Frank Neuner, Prof.
Organizational Affiliation
University of Konstanz
Official's Role
Principal Investigator
Facility Information:
Facility Name
University of Konstanz, Department of Psychology
City
Konstanz
ZIP/Postal Code
78467
Country
Germany

12. IPD Sharing Statement

Citations:
PubMed Identifier
22182346
Citation
Adenauer H, Catani C, Gola H, Keil J, Ruf M, Schauer M, Neuner F. Narrative exposure therapy for PTSD increases top-down processing of aversive stimuli--evidence from a randomized controlled treatment trial. BMC Neurosci. 2011 Dec 19;12:127. doi: 10.1186/1471-2202-12-127.
Results Reference
derived
PubMed Identifier
20619396
Citation
Adenauer H, Pinosch S, Catani C, Gola H, Keil J, Kissler J, Neuner F. Early processing of threat cues in posttraumatic stress disorder-evidence for a cortical vigilance-avoidance reaction. Biol Psychiatry. 2010 Sep 1;68(5):451-8. doi: 10.1016/j.biopsych.2010.05.015.
Results Reference
derived

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Change of Neural Network Indicators Through Narrative Treatment of PTSD in Torture Victims

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