Changes in Brain Activity Associated With Upper Limb Motor Recovery
Stroke
About this trial
This is an interventional treatment trial for Stroke focused on measuring stroke, rehabilitation, upper limb, TMS, tDCS
Eligibility Criteria
Inclusion Criteria:
- Male or female aged 21-80 years;
- First ever haemorrhagic or ischaemic hemiplegic stroke less than 1 month prior to study enrollment;
- Upper extremity impairment of 0-45 out of a maximum score of 66 on the Fugl-Meyer assessment scale.
- MMSE>=24.
- Be able to provide informed consent.
Exclusion Criteria:
pregnancy; cardiac pacemakers; orthodontics (braces); metal implant; history of epilepsy; sensorimotor disturbance due to other causes other than stroke; uncontrolled medical conditions including hypertension, diabetes mellitus and unstable angina; major depression and a history of psychotic disorders.
Sites / Locations
- National University Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Sham Comparator
No Intervention
real tDCS
sham tDCS
no stimulation
Subjects will receive tDCS stimulation at the intensity of 1 mA and last for 20 minutes. The anode will be placed over the affected primary motor cortex (M1) of cortical representation of the hand, while the cathode will be used as reference electrode and placed over the forehead of the unaffected side.
Subjects will receive sham tDCS stimulation. The same stimulation parameters as tDCS treatment will be employed for the sham stimulation. However, the current will be applied for 30 seconds only, to give subjects the sensation of the stimulation.
Subjects will not received any intervention.