Characterization of Myocardial Interstitial Fibrosis and Cardiomyocyte Hypertrophy by Cardiac MRI in Heart Failure
Heart Failure
About this trial
This is an interventional treatment trial for Heart Failure focused on measuring Heart Failure, Hypertrophy, Fibrosis, Magnetic Resonance
Eligibility Criteria
Inclusion Criteria:
- Age> 18 years
- Functional limitation (New York Heart Association Class II or worse)
- No contraindication to exercise (American College of Cardiology / American Heart Association criteria)
- Eligibility to take MRI (absence of metallic devices, and glomerular filtration rate > 40ml / min / 1.73m2, etc.)
- Prior diagnosis of Heart Failure (by the Framingham criterion)
- Therapy with diuretic and euvolemia state (evaluated by cardiologist and cardiopulmonary exercise testing)
- Transthoracic echocardiogram
Exclusion Criteria:
- Severe ischemia in any stress test
- Hypertrophic cardiomyopathy or any infiltrative heart disease
- Chronic obstructive pulmonary disease , pulmonary hypertension (Pulmonary artery pressure> 60mmHg)
- Severe left or right valve disease.
- Pacemaker or implantable cardioverter defibrillator
- Myocardial infarction or revascularization in 3 months
- Anemia (hemoglobin <10 grams / dl) until 1 month before cardiopulmonary exercise testing
Sites / Locations
- University of CampinasRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
No Intervention
Other
No Intervention
Other
Conventional Clinical Care - HFpEF
Supervised Exercise Training- HFpEF
Conventional Clinical Care - HFrEF
Supervised Exercise Training - HFrEF
Heart Failure patients with preserved ejection fraction (HFpEF) randomized to this arm will keep receiving their conventional clinical care, being instructed to continue and maintain their usual daily activities.
Heart Failure patients with preserved ejection fraction (HFpEF) randomized to this arm will keep receiving their conventional clinical care and participate in a supervised, facility based training program consisting of stretching exercises and aerobic exercise in treadmill.
Heart Failure patients with reduced ejection fraction (HFrEF) randomized to this arm will keep receiving their conventional clinical care, being instructed to continue and maintain their usual daily activities.
Heart Failure patients with reduced ejection fraction (HFrEF) randomized to this arm will keep receiving their conventional clinical care and participate in a supervised, facility based training program consisting of stretching exercises and aerobic exercise in treadmill.