Characterizing Iodine-124 Evuzumitide (AT-01) in Systemic Amyloidosis
Amyloidosis, Transthyretin Amyloidosis
About this trial
This is an interventional diagnostic trial for Amyloidosis
Eligibility Criteria
Inclusion Criteria: Subjects will at least have one of the following conditions: systemic amyloidosis with known organ involvement, carrier of a known pathogenic mutation in the transthyretin gene, multiple myeloma, and monoclonal gammopathy of undetermined significance Patient willing to consent for the study and undergo the study procedures. Exclusion Criteria: Has severe claustrophobia or any medical condition that would prevent completion of the imaging protocol Has a known allergy to potassium iodide treatment or to gadolinium. Patients on dialysis or those with eGFR <30 cc/min/1.73 m2 will be excluded from undergoing gadolinium-enhanced cardiac MRI. Has received heparin or heparin analogs (e.g., enoxaparin, dalteparin, fondaparinux) within 7 days prior to 124I-Evuzumitide administration
Sites / Locations
- Oregon Health & Science UniversityRecruiting
Arms of the Study
Arm 1
Experimental
Patients with ATTR-CM
Patients with ATTR-CM will undergo hybrid 124I-Evuzamitide PET/MRI imaging (or PET/CT) at baseline and in a subgroup, repeat imaging will be performed at an interval of 6-12 months.