Chemoradiotherapy Followed by Surgery for Advanced Paranasal Sinus Cancer
Paranasal Sinus Neoplasms
About this trial
This is an interventional treatment trial for Paranasal Sinus Neoplasms
Eligibility Criteria
Inclusion Criteria: Karnofsky Performance Score: >= 60 Creatinin clearance >= 50 ml/min or serum creatinine =<1.5 mg/dl Total bilirubin, AST, ALT =< 1.5 X laboratory uln ANC >= 2000/mm3, platelets >= 100,000/mm3 Serum calcium within normal range T3 or T4 state tumors of paranasal sinuses Squamous cell carcinoma, adenocarcinoma, high-grade mucoepidermoid carcinoma, sinonasal undifferentiated carcinoma Exclusion Criteria: History of other malignancy in the last 3 years Other serious comorbidity that may significantly reduce the survival in next 5 years Pregnant or lactating women History of radiation to the head and neck region Paranasal sinus tumor is recurrent after prior treatment Presence of cervical node metastasis Presence of distant metastasis Advanced nasopharyngeal malignancy with sphenoid or posterior ethmoid invasion