Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma
Multiple Myeloma and Plasma Cell Neoplasm
About this trial
This is an interventional treatment trial for Multiple Myeloma and Plasma Cell Neoplasm focused on measuring refractory multiple myeloma, stage I multiple myeloma, stage II multiple myeloma, stage III multiple myeloma
Eligibility Criteria
DISEASE CHARACTERISTICS: Diagnosis of multiple myeloma meeting 1 of the following criteria: Bone marrow plasmacytosis with at least 10% plasma cells Sheets of plasma cells Biopsy-proven plasmacytoma Meets at least 1 of the following criteria: Presence of myeloma (M)-protein in the serum Presence of M-protein in the urine Radiographic evidence of osteolytic lesions Generalized osteoporosis allowed if at least 20% plasma cells in bone marrow No non-secretory myeloma Prior M-protein in serum or urine allowed provided patient is now in complete remission Must be receiving conventional-dose chemotherapy as initial therapy or as salvage therapy Must have HLA-A, -B, and -DR genotypically identical sibling donor PATIENT CHARACTERISTICS: Age: 18 to 70 Performance status: ECOG 0-2 Life expectancy: Not specified Hematopoietic: See Disease Characteristics Hepatic: AST no greater than 3 times upper limit of normal Bilirubin less than 2.0 mg/dL Renal: Not specified Cardiovascular: LVEF greater than 40% at rest if symptomatic cardiac disease is present Pulmonary: DLCO greater than 50% of predicted (corrected for hemoglobin) if symptomatic pulmonary disease is present Other: Not pregnant or nursing Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: No prior autologous or allogeneic peripheral blood stem cell or bone marrow transplantation Chemotherapy: See Disease Characteristics More than 28 days since prior chemotherapy (including primary chemotherapy for hematopoietic stem cell collection) No other concurrent cytotoxic chemotherapy between autologous and allogeneic transplantation Endocrine therapy: Prior dexamethasone or other corticosteroids allowed Concurrent corticosteroids between autologous and allogeneic transplantation allowed Radiotherapy: Concurrent radiotherapy between autologous and allogeneic transplantation allowed Surgery: Not specified
Sites / Locations
- Baptist Cancer Institute - Jacksonville
- Mayo Clinic - Jacksonville
- Cancer Center at Tufts - New England Medical Center
- Beth Israel Deaconess Medical Center
- Mayo Clinic Cancer Center
- CCOP - Northern New Jersey
- Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
- MBCCOP-Our Lady of Mercy Cancer Center
- Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University
- MetroHealth's Cancer Care Center at MetroHealth Medical Center
- Penn State Cancer Institute at Milton S. Hershey Medical Center
- Abramson Cancer Center at the University of Pennsylvania