Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer
Esophageal Cancer, Gastric Cancer
About this trial
This is an interventional treatment trial for Esophageal Cancer focused on measuring stage I gastric cancer, stage II gastric cancer, stage III gastric cancer, adenocarcinoma of the stomach, adenocarcinoma of the esophagus, stage I esophageal cancer, stage II esophageal cancer, stage III esophageal cancer
Eligibility Criteria
Required Tumor Parameters 1.1 Patients must have histologically diagnosed adenocarcinoma of the stomach or gastroesophageal junction. Adenocarcinomas of the esophagus that are not involving the gastroesophageal junction are not eligible. 1.2 Patients must have had en bloc resection of all known tumor. The surgical resection must have been done with a curative intent. 1.3 Patients must have tumor extension beyond muscularis propria and/or nodal involvement without evidence of M1 disease. Patients can have stages IB if there is evidence of either node-positive (N1) disease or tumor extension beyond the muscularis propria (i.e., T1, N1, M0 patients are eligible but patients with T2, N0, M0 are allowed only if there is extension beyond the muscularis propria). Patients can have stages II, IIIA, IIIB or stage IV with M0 (i.e., T4N2M0). Stages 0, IA, or any stage with M1 are not allowed. (see Appendix I for TNM staging guide). 1.4 Patients with known unresected cancer, recurrent cancer, microscopic evidence of tumor at the distal or proximal line of stomach resection, noncontiguous resection of tumor, or M1 (metastatic) disease are ineligible. Prior Therapy 2.1 No prior therapy (except hormonal or biologic) for other malignancies is allowed except for adequately treated basal cell or squamous cell skin cancer, noninvasive carcinoma in situ which has been fully resected, or other cancer for which the patient has been disease free for five years. 2.2 Patients who have had any previous chemotherapy or radiotherapy are ineligible. Patient Characteristics 3.1 Patients must have an ECOG (CTC) performance status of 0, 1 or 2. 3.2 Patients are required to have an adequate total caloric intake to allow them to maintain their post-surgical body weight. Patients must have documentation of stable weight (or less than 2 pounds weight loss) for at least one week prior to registration. 3.3 All patients must be evaluated by a radiation oncologist (prior to enrollment) to ensure that the patient is an appropriate candidate for radiation therapy. 3.4 Patients may not have unilateral renal function (only one functioning kidney) as determined by CT scan with contrast, urogram, renal scan, or other study. 3.5 Pregnant or lactating women may not participate. Men and women of reproductive potential may not participate unless they have agreed to use an effective contraceptive method or practice abstinence while in this study. The effects of therapeutic radiotherapy are known to be teratogenic. The effects of Epirubicin, Cisplatin, and 5-FU on a developing human fetus at the recommended therapeutic dose are less well known. For this reason and because DNA alkylating agents are known to be teratogenic, women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating on this study, she should inform her treating physician immediately. Because the risk of toxicity in nursing infants secondary to Epirubicin, Cisplatin, and 5-FU treatment of the mother is unknown but may be harmful, breastfeeding should be discontinued. 3.6 Patients with any of the following cardiac conditions are ineligible: Uncontrolled high blood pressure Unstable angina Symptomatic congestive heart failure Myocardial infarction < 6 months prior to registration Serious uncontrolled cardiac arrhythmia New York Heart Association classification III or IV. 3.7 No uncontrolled serious medical or psychiatric illness which would prevent compliance with treatment or adequate informed consent. 3.8 Patients with active infectious process are ineligible. 3.9 Patients with grade 2 or greater peripheral neuropathy at baseline are ineligible. Required Initial Laboratory Values: Granulocytes ≥ 1,500/μl Platelet count ≥ 100,000/μl Creatinine ≤ 1.5 mg/dl Bilirubin ≤ 2.0 mg/dl AST ≤ 3x upper limits of normal
Sites / Locations
- Regional Medical Center
- Providence Cancer Center at Providence Hospital
- Mayo Clinic Scottsdale
- Arizona Cancer Center at University of Arizona Health Sciences Center
- Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
- Ben E. Owens Cancer Treatment Center at St. Bernard's Medical Center
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
- Kaiser Permanente - Deer Valley
- Providence Saint Joseph Medical Center - Burbank
- East Bay Radiation Oncology Center
- Eden Medical Center
- Valley Medical Oncology Consultants - Castro Valley
- City of Hope Comprehensive Cancer Center
- Kaiser Permanente - Fremont
- Valley Medical Oncology
- Glendale Memorial Hospital Comprehensive Cancer Center
- Kaiser Permanente Medical Center - Hayward
- Rebecca and John Moores UCSD Cancer Center
- Contra Costa Regional Medical Center
- Memorial Medical Center
- Community Hospital of the Monterey Peninsula Comprehensive Cancer Center
- Camino Medical Group - Treatment Center
- El Camino Hospital Cancer Center
- Highland General Hospital
- Alta Bates Summit Medical Center - Summit Campus
- Bay Area Breast Surgeons, Incorporated
- CCOP - Bay Area Tumor Institute
- Larry G Strieff MD Medical Corporation
- Tom K Lee, Incorporated
- Kaiser Permanente Medical Center - Oakland
- Valley Care Medical Center
- Valley Medical Oncology Consultants - Pleasanton
- Kaiser Permanente Medical Center - Redwood City
- Kaiser Permanente Medical Center - Richmond
- Kaiser Permanente Medical Center - Roseville
- South Sacramento Kaiser-Permanente Medical Center
- Kaiser Permanente Medical Center - Sacramento
- San Francisco General Hospital Medical Center
- Kaiser Permanente Medical Center - San Francisco Geary Campus
- Kaiser Permanente Medical Center - Santa Teresa
- Doctors Medical Center - San Pablo Campus
- Kaiser Foundation Hospital - San Rafael
- Kaiser Permanente Medical Center - Santa Clara Kiely Campus
- Kaiser Permanente Medical Center - Santa Rosa
- Kaiser Permanente Medical Center - South San Francisco
- Kaiser Permanente Medical Facility - Stockton
- Kaiser Permanente Medical Center - Vallejo
- Kaiser Permanente Medical Center - Walnut Creek
- Aurora Presbyterian Hospital
- Boulder Community Hospital
- Memorial Hospital Cancer Center - Colorado Springs
- Penrose Cancer Center at Penrose Hospital
- St. Anthony Central Hospital
- Porter Adventist Hospital
- Presbyterian - St. Luke's Medical Center
- St. Joseph Hospital
- Rose Medical Center
- CCOP - Colorado Cancer Research Program
- Swedish Medical Center
- St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
- North Colorado Medical Center
- Sky Ridge Medical Center
- Hope Cancer Care Center at Longmont United Hospital
- McKee Medical Center
- St. Mary - Corwin Regional Medical Center
- North Suburban Medical Center
- Exempla Lutheran Medical Center
- Praxair Cancer Center at Danbury Hospital
- Helen and Harry Gray Cancer Center at Hartford Hospital
- Tunnell Cancer Center at Beebe Medical Center
- CCOP - Christiana Care Health Services
- Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
- Walter Reed Army Medical Center
- Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus
- Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
- Broward General Medical Center Cancer Center
- Memorial Cancer Institute at Memorial Regional Hospital
- Baptist Cancer Institute - Jacksonville
- Ella Milbank Foshay Cancer Center at Jupiter Medical Center
- Center for Cancer Care and Research at Watson Clinic, LLP
- CCOP - Mount Sinai Medical Center
- Sacred Heart Cancer Center at Sacred Heart Hospital
- West Florida Cancer Institute at West Florida Hospital - Pensacola
- Cleveland Clinic Florida - Weston
- Phoebe Cancer Center at Phoebe Putney Memorial Hospital
- Winship Cancer Institute of Emory University
- Veterans Affairs Medical Center - Atlanta (Decatur)
- Medical Center of Central Georgia
- Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
- Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
- Mountain States Tumor Institute at St. Luke's Regional Medical Center
- Rush-Copley Cancer Care Center
- Hematology Oncology Associates of Illinois - Berwyn
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University
- Hematology and Oncology Associates
- University of Illinois Cancer Center
- Veterans Affairs Medical Center - Chicago Westside Hospital
- Resurrection Medical Center
- University of Chicago Cancer Research Center
- Creticos Cancer Center at Advocate Illinois Masonic Medical Center
- Decatur Memorial Hospital Cancer Care Institute
- St. Anthony's Memorial Hospital
- Elmhurst Memorial Hospital
- Ingalls Cancer Care Center at Ingalls Memorial Hospital
- Veterans Affairs Medical Center - Hines
- Midwest Center for Hematology/Oncology
- Joliet Oncology-Hematology Associates, Limited - West
- La Grange Memorial Hospital
- North Shore Oncology and Hematology Associates, Limited - Libertyville
- Cardinal Bernardin Cancer Center at Loyola University Medical Center
- Edward Hospital Cancer Center
- Hematology Oncology Consultants - Naperville
- La Grange Oncology Associates - Geneva
- Cancer Care and Hematology Specialists of Chicagoland - Niles
- Advocate Christ Medical Center
- Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields
- West Suburban Center for Cancer Care
- Swedish-American Regional Cancer Center
- Hematology Oncology Associates - Skokie
- Regional Cancer Center at Memorial Medical Center
- Carle Cancer Center at Carle Foundation Hospital
- CCOP - Carle Cancer Center
- St. Francis Hospital and Health Centers - Beech Grove Campus
- Elkhart General Hospital
- Fort Wayne Medical Oncology and Hematology
- Indiana University Melvin and Bren Simon Cancer Center
- William N. Wishard Memorial Hospital
- Howard Community Hospital
- Center for Cancer Therapy at LaPorte Hospital and Health Services
- Saint Anthony Memorial Health Centers
- Cancer Center at Ball Memorial Hospital
- Medical Consultants, PC at Ball Memorial Cancer Center
- Community Hospital
- Reid Hospital & Health Care Services
- CCOP - Northern Indiana CR Consortium
- Memorial Hospital of South Bend
- Saint Joseph Regional Medical Center
- South Bend Clinic
- McFarland Clinic, PC
- Hematology Oncology Associates of the Quad Cities
- Iowa Blood and Cancer Care
- St. Luke's Hospital
- Mercy Regional Cancer Center at Mercy Medical Center
- Mercy Capitol Hospital
- CCOP - Iowa Oncology Research Association
- John Stoddard Cancer Center at Iowa Methodist Medical Center
- Medical Oncology and Hematology Associates at John Stoddard Cancer Center
- Medical Oncology and Hematology Associates at Mercy Cancer Center
- Mercy Cancer Center at Mercy Medical Center - Des Moines
- John Stoddard Cancer Center at Iowa Lutheran Hospital
- Holden Comprehensive Cancer Center at University of Iowa
- McCreery Cancer Center at Ottumwa Regional
- Siouxland Hematology-Oncology Associates, LLP
- Mercy Medical Center - Sioux City
- St. Luke's Regional Medical Center
- Cedar Valley Medical Specialists, PC - West Ridgeway Avenue
- Covenant Cancer Treatment Center
- Medical Oncology and Hematology Associates - West Des Moines
- Cancer Center of Kansas, PA - Chanute
- Cancer Center of Kansas, PA - Dodge City
- Cancer Center of Kansas, PA - El Dorado
- Cancer Center of Kansas - Fort Scott
- Cancer Center of Kansas-Independence
- Cancer Center of Kansas, PA - Kingman
- Lawrence Memorial Hospital
- Southwest Medical Center
- Cancer Center of Kansas, PA - Newton
- Menorah Medical Center
- Cancer Center of Kansas, PA - Parsons
- Cancer Center of Kansas, PA - Pratt
- Cancer Center of Kansas, PA - Salina
- Tammy Walker Cancer Center at Salina Regional Health Center
- Shawnee Mission Medical Center
- Cotton-O'Neil Cancer Center
- St. Francis Comprehensive Cancer Center
- Cancer Center of Kansas, PA - Wellington
- Associates in Womens Health, PA - North Review
- Cancer Center of Kansas, PA - Medical Arts Tower
- Cancer Center of Kansas, PA - Wichita
- CCOP - Wichita
- Via Christi Cancer Center at Via Christi Regional Medical Center
- Wesley Medical Center
- Cancer Center of Kansas, PA - Winfield
- Pennington Cancer Center at Baton Rouge General
- Mary Bird Perkins Cancer Center - Baton Rouge
- Ochsner Health Center - Bluebonnet
- Ochsner Health Center - Covington
- Terrebonne General Medical Center
- MBCCOP - LSU Health Sciences Center
- Medical Center of Louisiana - New Orleans
- CCOP - Ochsner
- Ochsner Cancer Institute at Ochsner Clinic Foundation
- Greenebaum Cancer Center at University of Maryland Medical Center
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Shore Regional Cancer Center at Memorial Hospital - Easton
- Union Hospital Cancer Program at Union Hospital
- Associates in Oncology and Hematology
- Associates in Oncology and Hematology - Medical Center Drive
- Tufts-NEMC Cancer Center
- Massachusetts General Hospital
- Dana-Farber/Brigham and Women's Cancer Center
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
- Boston University Cancer Research Center
- Beth Israel Deaconess Medical Center
- Caritas St. Elizabeth's Medical Center
- Lahey Clinic Medical Center - Burlington
- Hudner Oncology Center at Saint Anne's Hospital - Fall River
- Addison Gilbert Hospital
- Cape Cod Hospital
- Lowell General Hospital
- Berkshire Hematology Oncology, PC
- South Shore Hospital
- Morton Hospital & Medical Center
- Hickman Cancer Center at Bixby Medical Center
- Saint Joseph Mercy Cancer Center
- CCOP - Michigan Cancer Research Consortium
- University of Michigan Comprehensive Cancer Center
- Battle Creek Health System Cancer Care Center
- Bay Regional Medical Center
- Mecosta County Medical Center
- Oakwood Cancer Center at Oakwood Hospital and Medical Center
- Green Bay Oncology, Limited - Escanaba
- Genesys Hurley Cancer Institute
- Hurley Medical Center
- Butterworth Hospital at Spectrum Health
- CCOP - Grand Rapids
- Lacks Cancer Center at Saint Mary's Health Care
- Van Elslander Cancer Center at St. John Hospital and Medical Center
- Dickinson County Healthcare System
- Foote Memorial Hospital
- Borgess Medical Center
- West Michigan Cancer Center
- Bronson Methodist Hospital
- Haematology-Oncology Associates of Ohio and Michigan, PC
- Sparrow Regional Cancer Center
- St. Mary Mercy Hospital
- Community Cancer Center of Monroe
- Mercy Memorial Hospital - Monroe
- Mercy General Health Partners
- St. Joseph Mercy Oakland
- Mercy Regional Cancer Center at Mercy Hospital
- William Beaumont Hospital - Royal Oak Campus
- Seton Cancer Institute at Saint Mary's - Saginaw
- Lakeland Regional Cancer Care Center - St. Joseph
- Oncology Care Associates, PLLC
- Munson Medical Center
- St. John Macomb Hospital
- Metro Health Hospital
- Fairview Ridges Hospital
- Mercy and Unity Cancer Center at Mercy Hospital
- Duluth Clinic Cancer Center - Duluth
- CCOP - Duluth
- Miller - Dwan Medical Center
- Fairview Southdale Hospital
- Mercy and Unity Cancer Center at Unity Hospital
- Hutchinson Area Health Care
- Meeker County Memorial Hospital
- HealthEast Cancer Care at St. John's Hospital
- Minnesota Oncology Hematology, PA - Maplewood
- Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
- Hennepin County Medical Center - Minneapolis
- Masonic Cancer Center at University of Minnesota
- Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
- Mayo Clinic Cancer Center
- CentraCare Clinic - River Campus
- Coborn Cancer Center
- CCOP - Metro-Minnesota
- Park Nicollet Cancer Center
- Regions Hospital Cancer Care Center
- HealthEast Cancer Care at St. Joseph's Hospital
- United Hospital
- St. Francis Cancer Center at St. Francis Medical Center
- Ridgeview Medical Center
- Willmar Cancer Center at Rice Memorial Hospital
- HealthEast Cancer Care at Woodwinds Health Campus
- Minnesota Oncology Hematology, PA - Woodbury
- Hattiesburg Clinic, PA at Forrest General
- Hematology & Oncology Clinic
- Regional Cancer Center at Singing River Hospital
- Ellis Fischel Cancer Center at University of Missouri - Columbia
- Independence Regional Health Center
- Truman Medical Center - Hospital Hill
- Saint Luke's Cancer Institute at Saint Luke's Hospital
- St. Joseph Medical Center
- North Kansas City Hospital
- Parvin Radiation Oncology
- CCOP - Kansas City
- Research Medical Center
- Liberty Hospital
- Heartland Regional Medical Center
- Missouri Baptist Cancer Center
- Christian Hospital Northeast Cancer Care Center
- Arch Medical Services, Incorporated at Center for Cancer Care and Research
- CCOP - Cancer Research for the Ozarks
- St. John's Regional Health Center
- Hulston Cancer Center at Cox Medical Center South
- CCOP - Montana Cancer Consortium
- Hematology-Oncology Centers of the Northern Rockies - Billings
- Northern Rockies Radiation Oncology Center
- St. Vincent Healthcare Cancer Care Services
- Billings Clinic - Downtown
- St. James Healthcare Cancer Care
- Big Sky Oncology
- Great Falls Clinic - Main Facility
- Sletten Cancer Institute at Benefis Healthcare
- Northern Montana Hospital
- Glacier Oncology, PLLC
- Kalispell Medical Oncology at KRMC
- Kalispell Regional Medical Center
- Community Medical Center
- Guardian Oncology and Center for Wellness
- Montana Cancer Specialists at Montana Cancer Center
- Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
- Good Samaritan Cancer Center at Good Samaritan Hospital
- Cancer Resource Center - Lincoln
- CCOP - Missouri Valley Cancer Consortium
- Methodist Estabrook Cancer Center
- Immanuel Medical Center
- Alegant Health Cancer Center at Bergan Mercy Medical Center
- Creighton University Medical Center
- University Medical Center of Southern Nevada
- CCOP - Nevada Cancer Research Foundation
- Elliot Regional Cancer Center at Elliot Hospital
- John F. Kennedy Medical Center
- CentraState Medical Center
- St. Barnabas Medical Center Cancer Center
- Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
- Carol G. Simon Cancer Center at Morristown Memorial Hospital
- Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
- Overlook Hospital
- Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
- Cancer Institute of New Jersey at Cooper - Voorhees
- Fox Chase Virtua Health Cancer Program at Virtua West Jersey
- Our Lady of Mercy Medical Center Comprehensive Cancer Center
- Kings County Hospital Center
- SUNY Downstate Medical Center
- Veterans Affairs Medical Center - Buffalo
- CCOP - Hematology-Oncology Associates of Central New York
- Ralph Lauren Center for Cancer Care and Prevention
- Memorial Sloan-Kettering Cancer Center
- James P. Wilmot Cancer Center at University of Rochester Medical Center
- Nalitt Cancer Institute at Staten Island University Hospital
- SUNY Upstate Medical University Hospital
- Mission Hospitals - Memorial Campus
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
- Blumenthal Cancer Center at Carolinas Medical Center
- Presbyterian Cancer Center at Presbyterian Hospital
- Wayne Memorial Hospital, Incorporated
- Leo W. Jenkins Cancer Center at ECU Medical School
- Kinston Medical Specialists
- FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
- Rutherford Hospital
- Wake Forest University Comprehensive Cancer Center
- Bismarck Cancer Center
- Medcenter One Hospital Cancer Care Center
- Mid Dakota Clinic, PC
- St. Alexius Medical Center Cancer Center
- Dakota Cancer Institute at Dakota Clinic - South University
- Altru Cancer Center at Altru Hospital
- McDowell Cancer Center at Akron General Medical Center
- Summa Center for Cancer Care at Akron City Hospital
- Mary Rutan Hospital
- Wood County Oncology Center
- Aultman Cancer Center at Aultman Hospital
- Adena Regional Medical Center
- MetroHealth Cancer Care Center at MetroHealth Medical Center
- North Coast Cancer Care - Clyde
- Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
- Riverside Methodist Hospital Cancer Care
- CCOP - Columbus
- Grant Medical Center Cancer Care
- Mount Carmel Health - West Hospital
- Doctors Hospital at Ohio Health
- Grandview Hospital
- Good Samaritan Hospital
- Veterans Affairs Medical Center - Dayton
- CCOP - Dayton
- Grady Memorial Hospital
- Hematology Oncology Center
- Blanchard Valley Medical Associates
- Middletown Regional Hospital
- Charles F. Kettering Memorial Hospital
- Fairfield Medical Center
- St. Rita's Medical Center
- Lima Memorial Hospital
- Strecker Cancer Center at Marietta Memorial Hospital
- Northwest Ohio Oncology Center
- St. Luke's Hospital
- Licking Memorial Cancer Care Program at Licking Memorial Hospital
- St. Charles Mercy Hospital
- Toledo Clinic - Oregon
- Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford
- North Coast Cancer Care, Incorporated
- Mercy Medical Center
- Community Hospital of Springfield and Clark County
- Flower Hospital Cancer Center
- Mercy Hospital of Tiffin
- Toledo Hospital
- St. Vincent Mercy Medical Center
- Medical University of Ohio Cancer Center
- CCOP - Toledo Community Hospital
- St. Anne Mercy Hospital
- Toledo Clinic, Incorporated - Main Clinic
- UVMC Cancer Care Center at Upper Valley Medical Center
- Fulton County Health Center
- Mount Carmel St. Ann's Cancer Center
- Clinton Memorial Hospital
- Cancer Treatment Center
- Ruth G. McMillan Cancer Center at Greene Memorial Hospital
- Genesis - Good Samaritan Hospital
- Cleo Craig Cancer Research Clinic
- Oklahoma University Cancer Institute
- Cancer Care Associates - Mercy Campus
- Kaiser Permanente Health Care - Portland
- Salem Hospital Regional Cancer Care Services
- Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
- UPMC Cancer Center at Beaver Medical Center
- St. Luke's Cancer Network at St. Luke's Hospital
- Bryn Mawr Hospital
- UPMC Cancer Center at Jefferson Regional Medical Center
- Geisinger Cancer Institute at Geisinger Health
- Oncology Hematology Associates of Northern Pennsylvania, PC at Hahne Regional Cancer Center
- Dale and Frances Hughes Cancer Center at Pocono Medical Center
- Easton Regional Cancer Center at Easton Hospital
- UPMC Cancer Center - Arnold Palmer Pavilion
- Penn State Cancer Institute at Milton S. Hershey Medical Center
- UPMC Cancer Center at the John P. Murtha Pavilion
- St. Mary Regional Cancer Center
- Lewistown Hospital
- Riddle Memorial Hospital Cancer Center
- UPMC - Moon
- UPMC Cancer Center - Natrona Heights
- Jameson Memorial Hospital - North Campus
- Cancer Center of Paoli Memorial Hospital
- Abramson Cancer Center of the University of Pennsylvania
- Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
- Joan Karnell Cancer Center at Pennsylvania Hospital
- Fox Chase Cancer Center - Philadelphia
- Frankford Hospital Cancer Center - Torresdale Campus
- Albert Einstein Cancer Center
- UPMC - Shadyside
- UPMC Cancer Center at UPMC St. Margaret
- Mercy Cancer Institute at Mercy Hospital
- UPMC Cancer Centers
- UPMC Cancer Center at UPMC Passavant
- St. Clair Memorial Hospital Cancer Center
- Guthrie Cancer Center at Guthrie Clinic Sayre
- Mercy Hospital Cancer Center - Scranton
- Hematology and Oncology Associates of Northeastern Pennsylvania
- Grand View Hospital
- UPMC Cancer Center at UPMC Northwest
- Geisinger Medical Group - Scenery Park
- Mount Nittany Medical Center
- Washington Hospital Cancer Center
- Jennersville Regional Hospital
- Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
- CCOP - Main Line Health
- Lankenau Cancer Center at Lankenau Hospital
- Hematology and Oncology Associates of Rhode Island
- Memorial Hospital of Rhode Island
- Kent County Memorial Hospital
- AnMed Cancer Center
- Roper St. Francis Cancer Center at Roper Hospital
- CCOP - Greenville
- CCOP - Upstate Carolina
- Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
- Avera Cancer Institute
- Medical X-Ray Center, PC
- Sanford Cancer Center at Sanford USD Medical Center
- Blue Ridge Medical Specialists, PC
- Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
- Thompson Cancer Survival Center
- Brooke Army Medical Center
- Wilford Hall Medical Center
- Doctor's Hospital of Laredo
- CCOP - Scott and White Hospital
- American Fork Hospital
- Sandra L. Maxwell Cancer Center
- Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
- Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
- Utah Valley Regional Medical Center - Provo
- Dixie Regional Medical Center - East Campus
- LDS Hospital
- Utah Cancer Specialists at UCS Cancer Center
- Huntsman Cancer Institute at University of Utah
- Danville Regional Medical Center
- Fredericksburg Oncology, Incorporated
- Virginia Oncology Associates - Hampton
- Lynchburg Hematology-Oncology Clinic
- Southwest Virginia Regional Cancer Center at Wellmonth Health
- Virginia Commonwealth University Massey Cancer Center
- St. Joseph Cancer Center
- Olympic Hematology and Oncology
- Columbia Basin Hematology
- Fred Hutchinson Cancer Research Center
- Harborview Medical Center
- Minor and James Medical, PLLC
- Group Health Central Hospital
- Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
- Polyclinic First Hill
- University Cancer Center at University of Washington Medical Center
- Cancer Care Northwest - Spokane South
- Madigan Army Medical Center - Tacoma
- West Virginia University Health Sciences Center - Charleston
- Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
- Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital
- Princeton Community Hospital
- Marshfield Clinic Cancer Care at Regional Cancer Center
- Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
- Green Bay Oncology, Limited at St. Mary's Hospital
- St. Mary's Hospital Medical Center - Green Bay
- St. Vincent Hospital Regional Cancer Center
- Bay Area Cancer Care Center at Bay Area Medical Center
- Marshfield Clinic - Marshfield Center
- Medical College of Wisconsin Cancer Center
- Marshfield Clinic - Lakeland Center
- Regional Cancer Center at Oconomowoc Memorial Hospital
- Green Bay Oncology, Limited - Oconto Falls
- Ministry Medical Group at Saint Mary's Hospital
- Marshfield Clinic - Indianhead Center
- Green Bay Oncology, Limited - Sturgeon Bay
- Waukesha Memorial Hospital Regional Cancer Center
- Marshfield Clinic - Weston Center
- Marshfield Clinic - Wisconsin Rapids Center
- Cross Cancer Institute at University of Alberta
- CancerCare Manitoba
- Saint John Regional Hospital
- Margaret and Charles Juravinski Cancer Centre
- Cancer Centre of Southeastern Ontario at Kingston General Hospital
- London Regional Cancer Program at London Health Sciences Centre
- Ottawa Hospital Regional Cancer Centre - General Campus
- Allan Blair Cancer Centre at Pasqua Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Arm I
Arm II
Patients receive leucovorin calcium IV and fluorouracil (5-FU) IV on days 1-5 of courses 1, 3, and 4. Courses repeat every 28 days. During course 2, patients undergo radiotherapy 5 days a week and receive 5-FU IV continuously for 5 to 6 weeks. Patients rest for 28-35 days between course 2 and 3.
Patients receive epirubicin IV over 3-15 minutes and cisplatin IV over 1 hour on day 1 and 5-FU IV continuously on days 1-21 during course 1. Beginning 1 week later, patients undergo radiotherapy 5 days a week and 5-FU IV continuously for 5 weeks. Patients rest for 28-35 days before beginning course 2 of chemotherapy. Patients then receive epirubicin, cisplatin, and 5-FU as in course 1. Treatment repeats every 21 days for 2 courses.