Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer
Anal Cancer
About this trial
This is an interventional treatment trial for Anal Cancer focused on measuring stage II anal cancer, stage III anal cancer, squamous cell carcinoma of the anus, cloacogenic carcinoma of the anus, basaloid carcinoma of the anus
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed primary squamous, basaloid, or cloacogenic carcinoma of the anal canal, other than carcinoma in situ T2-4, Any N, M0 (stage II or III) No local or regional recurrence after local excision or abdominal peritoneal resection PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Karnofsky 60-100% Life expectancy: Not specified Hematopoietic: WBC at least 4,000/mm^3 Absolute neutrophil count at least 1,800/mm^3 Platelet count at least 100,000/mm^3 Hemoglobin at least 10 g/dL Hepatic: Bilirubin less than 1.4 mg/dL Renal: Creatinine no greater than 1.5 mg/dL OR Creatinine clearance at least 80 mL/min Cardiovascular: No uncompensated heart disease No uncontrolled high blood pressure Other: No AIDS No active systemic infection No uncontrolled diabetes No other prior malignancy within the past 5 years except nonmelanoma skin cancer No mental condition that would preclude study participation Not pregnant or nursing Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: Prior epoetin alfa allowed in lieu of blood transfusions Chemotherapy: At least 5 years since prior chemotherapy Endocrine therapy: Not specified Radiotherapy: At least 5 years since prior radiotherapy Surgery: No prior surgery of anal canal except for biopsy of study site
Sites / Locations
- Comprehensive Cancer Center at University of Alabama at Birmingham
- Mobile Infirmary Medical Center
- Alaska Regional Hospital
- Providence Alaska Medical Center
- Foundation for Cancer Research and Education
- CCOP - Mayo Clinic Scottsdale Oncology Program
- Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
- Alta Bates Comprehensive Cancer Center
- Providence Saint Joseph Medical Center - Burbank
- Mills-Peninsula Health Services
- Mount Diablo Regional Cancer Center
- City of Hope Comprehensive Cancer Center
- California Cancer Center - Woodward Park Office
- Marin Cancer Institute at Marin General Hospital
- Sutter Health Western Division Cancer Research Group
- Saint Rose Hospital
- Valley Memorial Hospital
- Loma Linda University Cancer Institute at Loma Linda University Medical Center
- USC/Norris Comprehensive Cancer Center and Hospital
- Providence Holy Cross Cancer Center
- Memorial Medical Center Cancer Services
- Leavey Cancer Center at Northridge Hospital Medical Center
- Highland General Hospital
- CCOP - Bay Area Tumor Institute
- Summit Medical Center
- Palo Alto Medical Foundation
- Pomona Valley Hospital Medical Center
- Radiological Associates of Sacramento Medical Group, Inc.
- University of California Davis Cancer Center
- Naval Medical Center - San Diego
- California Pacific Medical Center - California Campus
- J.C. Robinson, M.D. Regional Cancer Center
- CCOP - Santa Rosa Memorial Hospital
- Torrance Memorial Medical Center
- Sutter Solano Medical Center
- Aurora Presbyterian Hospital
- Boulder Community Hospital
- Memorial Hospital Cancer Center
- Penrose Cancer Center at Penrose Hospital
- Porter Adventist Hospital
- Presbyterian - St. Luke's Medical Center
- St. Joseph Hospital
- Rose Medical Center
- CCOP - Colorado Cancer Research Program, Incorporated
- Swedish Medical Center
- Front Range Cancer Specialists
- St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
- Sky Ridge Medical Center
- Hope Cancer Care Center at Longmont United Hospital
- St. Mary-Corwin Regional Medical Center
- North Suburban Medical Center
- Middlesex Hospital Cancer Center
- Beebe Medical Center
- CCOP - Christiana Care Health Services
- St. Francis Hospital
- Lombardi Cancer Center at Georgetown University Medical Center
- Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
- 21st Century Oncology - Fort Myers
- Memorial Cancer Institute at Memorial Regional Hospital
- Baptist Cancer Institute - Jacksonville
- Mayo Clinic - Jacksonville
- Ella Milbank Foshay Cancer Center at Jupiter Medical Center
- CCOP - Mount Sinai Medical Center
- University of Miami Sylvester Comprehensive Cancer Center
- Baptist-South Miami Regional Cancer Program
- Gulf Coast Cancer Treatment Center
- Tallahassee Memorial Hospital
- H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
- Emory University Hospital - Atlanta
- Northeast Georgia Medical Center
- Pearlman Comprehensive Cancer Center at South Georgia Medical Center
- Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
- Mountain States Tumor Institute - Boise
- Saint Anthony's Hospital at Saint Anthony's Health Center
- Northwest Community Hospital
- Rush-Copley Cancer Care Center
- Good Shepherd Hospital
- St. Joseph Medical Center
- Graham Hospital
- Memorial Hospital
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University
- Creticos Cancer Center at Advocate Illinois Masonic Medical Center
- Cancer Care Center at Advocate Good Samaritan Hospital
- St. Anthony's Memorial Hospital
- Eureka Hospital
- Evanston Northwestern Health Care - Evanston Hospital
- Galesburg Clinic
- Galesburg Cottage Hospital
- InterCommunity Cancer Center of Western Illinois
- Mason District Hospital
- Hinsdale Hematology Oncology Associates
- Hopedale Medical Complex
- Joliet Oncology Hematology Associates, Limited - West
- Kewanee Hospital
- McDonough District Hospital
- Edward Hospital Cancer Center
- BroMenn Regional Medical Center
- Community Cancer Center
- Community Hospital of Ottawa
- Oncology Hematology Associates of Central Illinois - Ottawa
- Lutheran General Cancer Care Center
- Cancer Treatment Center at Pekin Hospital
- Methodist Medical Center of Illinois
- Proctor Hospital
- CCOP - Illinois Oncology Research Association
- Oncology/Hematology Associates of Central Illinois, P.C.
- OSF St. Francis Medical Center
- Illinois Valley Community Hospital
- Perry Memorial Hospital
- Swedish American Hospital
- St. Margaret's Hospital
- Valley Cancer Center
- Carle Cancer Center at Carle Foundation Hospital
- CCOP - Carle Cancer Center
- St. Francis Hospital and Health Centers
- Bloomington Hospital
- Elkhart General Hospital
- Center for Cancer Therapy at LaPorte Hospital and Health Services
- Saint Anthony Memorial Health Centers
- Cancer Center at Ball Memorial Hospital
- Saint Joseph Regional Medical Center - Plymouth Campus
- CCOP - Northern Indiana CR Consortium
- Memorial Hospital of South Bend
- Union Hospital
- McFarland Clinic, P.C.
- Saint Anthony Regional Hospital
- St. Luke's Hospital
- Cedar Rapids Oncology Associates
- Mercy Cancer Center at Mercy Medical Center
- Alegent Health Mercy Hospital
- Genesis Regional Cancer Center at Genesis Medical Center
- Genesis Medical Center - West Campus
- Mercy Capitol Hospital
- CCOP - Iowa Oncology Research Association
- John Stoddard Cancer Center at Iowa Methodist Medical Center
- Medical Oncology and Hematology Associates at John Stoddard Cancer Center
- Medical Oncology and Hematology Associates at Mercy Cancer Center
- Mercy Cancer Center at Mercy Medical Center - Des Moines
- John Stoddard Cancer Center at Iowa Lutheran Hospital
- Wendt Regional Cancer Center at Finley Hospital
- Holden Comprehensive Cancer Center at University of Iowa
- Mercy Cancer Center at Mercy Medical Center - North Iowa
- Alegent Health Community Memorial Hospital
- Burgess Health Center
- Siouxland Hematology-Oncology Associates
- Mercy Medical Center - Sioux City
- St. Luke's Regional Medical Center
- Medical Oncology and Hematology Associates - West Des Moines
- South Central Kansas Regional Medical Center
- Cancer Center of Kansas - Chanute
- Cancer Center of Kansas - Dodge City
- Cancer Center of Kansas, P.A. - El Dorado
- Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
- Cancer Center of Kansas - Kingman
- Southwest Medical Center
- Cancer Center of Kansas - Newton
- Cancer Center of Kansas - Ottawa
- Cancer Center of Kansas, P.A. - Parsons
- Pratt Cancer Center of Kansas
- Cancer Center of Kansas - Salina
- Cancer Center of Kansas - Wellington
- Associates in Womens Health
- Cancer Center of Kansas, P.A.
- Cancer Center of Kansas, P.A. - Wichita
- CCOP - Wichita
- Via Christi Cancer Center at Via Christi Regional Medical Center
- Wesley Medical Center
- Cancer Center of Kansas - Winfield
- Cancer Treatment Center at the Medical Center - Bowling Green
- Central Baptist Hospital
- Markey Cancer Center at University of Kentucky Chandler Medical Center
- Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County
- Louisiana State University Health Sciences Center - Monroe
- Tulane Cancer Center
- Veterans Affairs Medical Center - Shreveport
- Feist-Weiller Cancer Center at Louisiana State University Health Sciences
- CancerCare of Maine at Eastern Maine Medial Center
- Central Maine Medical Center
- Maine General Medical Center - Waterville
- DeCesaris Cancer Institute at Anne Arundel Medical Center
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Union Hospital Cancer Center at Union Hospital
- Massachusetts General Hospital Cancer Center
- Brigham and Women's Hospital
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
- Cancer Research Center at Boston Medical Center
- Bethke Cancer Center at Emerson Hospital
- Hudner Oncology Center at Saint Anne's Hospital
- Cape Cod Hospital
- Newton - Wellesley Hospital
- South Suburban Oncology Center
- Hickman Cancer Center at Bixby Medical Center
- CCOP - Michigan Cancer Research Consortium
- St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital
- University of Michigan Comprehensive Cancer Center
- Battle Creek Health System
- Mecosta County General Hospital
- Josephine Ford Cancer Center at Henry Ford Health System
- Hurley Medical Center
- Genesys Hurley Cancer Institute
- Great Lakes Cancer Institute at McLaren Regional Medical Center
- CCOP - Grand Rapids
- Lacks Cancer Center at Saint Mary's Mercy Medical Center
- Spectrum Health Cancer Care - Butterworth Campus
- Metropolitan Hospital
- Spectrum Health Hospital - Blodgett Campus
- Holland Community Hospital
- Borgess Medical Center
- Bronson Methodist Hospital
- West Michigan Cancer Center
- Upper Michigan Cancer Center at Marquette General Hospital
- Hackley Hospital
- Northern Michigan Hospital
- Mercy Hospital
- Seton Cancer Institute - Saginaw
- Oncology Care Associates, P.L.L.C.
- Providence Cancer Institute at Providence Hospital - Southfield Campus
- Munson Medical Center
- St. John Macomb Hospital
- MeritCare Clinic - Bemidji
- Brainerd Medical Center
- Fairview Ridges Hospital
- Mercy Hospital
- Cancer Care Center at St. Luke's Hospital
- CCOP - Duluth
- Miller-Dwan Medical Center
- St. Mary's - Duluth Clinic Cancer Center
- Fairview Southdale Hospital
- Mercy and Unity Cancer Center at Mercy and Unity Hospitals
- Hutchinson Area Health Care
- Meeker County Memorial Hospital
- St. John's Hospital
- Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
- Hennepin County Medical Center - Minneapolis
- Fairview University Medical Center - University Campus
- Chippewa County - Montevideo Hospital
- Hubert H. Humphrey Cancer Center at North Memorial Medical Center
- Mayo Clinic Cancer Center
- CCOP - Metro-Minnesota
- Cancer Care Center at Regions Hospital
- Saint Francis Cancer Center
- St. Joseph's Hospital
- Adult and Pediatric Urology, P.L.L.P.
- CentraCare Clinic - River Campus
- Park Nicollet Clinic
- United Hospital
- Ridgeview Medical Center
- Rice Memorial Hospital
- Woodwinds Hospital
- University of Mississippi Medical Center
- Veterans Affairs Medical Center - Jackson
- Regional Cancer Center at Singing River Hospital
- St. Francis Medical Center
- Saint Luke's Hospital
- Missouri Cancer Associates
- Ellis Fischel Cancer Center at University of Missouri - Columbia
- Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
- CCOP - Kansas City
- St. John's Regional Health Center
- Hulston Cancer Center at Cox Medical Center South
- Siteman Cancer Center at Barnes-Jewish Hospital
- Missouri Baptist Cancer Center
- CCOP - St. Louis-Cape Girardeau
- Center for Cancer Care and Research
- David C. Pratt Cancer Center at St. John's Mercy
- CCOP - Montana Cancer Consortium
- Great Falls Clinic
- Sletten Regional Cancer Institute
- Fremont Area Medical Center
- Cancer Center at the Good Samaritan Health Systems
- Bryan LGH Medical Center West
- Cancer Resource Center - Lincoln
- St. Elizabeth Regional Medical Center
- CCOP - Missouri Valley Cancer Consortium
- Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha
- Alegent Health - Immanuel Medical Center
- Bergan Mercy Medical Center
- Cancer Center at Creighton University Medical Center
- Midlands Cancer Center at Midlands Community Hospital
- University Medical Center of Southern Nevada
- CCOP - Southern Nevada Cancer Research Foundation
- Sunrise Hospital and Medical Center
- Washoe Cancer Services at Washoe Medical Center - Reno
- Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
- Cancer Institute of New Jersey at the Cooper University Hospital
- CCOP - Northern New Jersey
- Monmouth Medical Center
- South Jersey Healthcare Regional Cancer Center
- Cancer Center at the Mountainside Hospital
- Fox Chase Virtua Health Cancer Program - Marlton
- Newark Beth Israel Medical Center
- Atlantic City Medical Center - Mainland Division
- Booker Cancer Center at Riverview Medical Center
- Community Medical Center
- Fox Chase Cancer Center at St. Francis Medical Center
- Capital Health System Regional Cancer Center
- Hematology-Oncology Associates, PC
- University of New Mexico Cancer Research and Treatment Center
- Lovelace Medical Center at Lovelace Sandia Health System
- SUNY Downstate Medical Center
- New York Methodist Hospital
- Finger Lakes Hematology and Oncology
- Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital
- Catskill Regional Medical Center
- CCOP - North Shore University Hospital
- New York Weill Cornell Cancer Center at Cornell University
- Highland Hospital of Rochester
- James P. Wilmot Cancer Center at University of Rochester Medical Center
- CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
- Crouse Hospital
- Veterans Affairs Medical Center - Syracuse
- Community General Hospital of Greater Syracuse
- Randolph Hospital
- Blumenthal Cancer Center at Carolinas Medical Center
- Presbyterian Cancer Center at Presbyterian Hospital
- John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial Hospital
- Wayne Memorial Hospital, Incorporated
- Wayne Radiation Oncology
- Moses Cone Regional Cancer Center at Wesley Long Community Hospital
- Lenoir Memorial Cancer Center
- Annie Penn Cancer Center
- Zimmer Cancer Center at New Hanover Regional Medical Center
- Wilson Medical Center
- Forsyth Regional Cancer Center at Forsyth Medical Center
- Bismarck Cancer Center
- Medcenter One Health System
- Mid Dakota Clinic, P.C.
- St. Alexius Medical Center
- CCOP - MeritCare Hospital
- MeritCare Medical Group
- Altru Cancer Center at Altru Hospital
- Trinity Cancer Care Center
- Akron City Hospital at Summa Health System
- McDowell Cancer Center at Akron General Medical Center
- University Hospitals Ireland Cancer Center at Mercy Medical Center
- Adena Regional Medical Center
- Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University
- MetroHealth's Cancer Care Center at MetroHealth Medical Center
- Huron Hospital Cancer Care Center
- Euclid Hospital
- Cleveland Clinic Taussig Cancer Center
- Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
- Riverside Methodist Hospital Cancer Care
- CCOP - Columbus
- Grant Riverside Cancer Services
- Mount Carmel West Hospital
- Doctors Hospital at Ohio Health
- Grandview Hospital
- Good Samaritan Hospital
- Miami Valley Hospital
- Samaritan North Cancer Care Center
- Veterans Affairs Medical Center - Dayton
- CCOP - Dayton
- Grady Memorial Hospital
- Charles F. Kettering Memorial Hospital
- Fairfield Medical Center
- St. Rita's Medical Center
- Lima Memorial Hospital
- Strecker Cancer Center at Marietta Memorial Hospital
- St. Luke's Hospital
- Hillcrest Cancer Center at Hillcrest Hospital
- Middletown Regional Hospital
- Licking Memorial Cancer Care Program at Licking Memorial Hospital
- St. Charles Mercy Hospital
- Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford
- Firelands Regional Medical Center
- Mercy Medical Center Oncology Unit
- Community Hospital of Springfield and Clark County
- Promedica Cancer Center at Flower Hospital
- Mercy Hospital of Tiffin
- Toledo Hospital
- St. Vincent Mercy Medical Center
- Medical College of Ohio Cancer Institute
- CCOP - Toledo Community Hospital
- Toledo Clinic, Incorporated
- UVMC Cancer Care Center at Upper Valley Medical Center
- South Pointe Hospital Cancer Care Center
- Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital
- Cancer Treatment Center
- Ruth G. McMillan Cancer Center at Greene Memorial Hospital
- Genesis - Good Samaritan Hospital
- LaFortune Cancer Center at St. John Health System
- Natalie Warren Bryant Cancer Center at St. Francis Hospital
- Legacy Mount Hood Medical Center
- Providence Milwaukie Hospital
- Comprehensive Cancer Center at Legacy Good Samaritan Hospital & Medical Center
- Providence Cancer Center at Providence Portland Medical Center
- CCOP - Columbia River Oncology Program
- Providence St. Vincent Medical Center
- Institute of Oncology at Vilnius University
- Kaiser Permanente Health Care - Portland
- Cancer Institute at Oregon Health and Science University
- Salem Hospital Regional Cancer Center
- Legacy Meridian Park Hospital
- John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital
- St. Luke's Hospital Cancer Center
- Bryn Mawr Hospital
- Geisinger Medical Center
- Delaware County Regional Cancer Center at Delaware County Memorial Hospital
- Penn State Cancer Institute at Milton S. Hershey Medical Center
- St. Mary Regional Cancer Center
- Lewistown Hospital
- Cancer Center at Paoli Memorial Hospital
- Joan Karnell Cancer Center at Pennsylvania Hospital
- Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
- Fox Chase Cancer Center
- Albert Einstein Cancer Center
- Allegheny Cancer Center at Allegheny General Hospital
- Mercy Hospital of Pittsburgh
- Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
- Pottstown Memorial Regional Cancer Center
- St. Joseph Medical Center
- Guthrie Medical Center - Sayre
- Mercy Hospital Cancer Center - Scranton
- Geisinger Medical Group
- Mount Nittany Medical Center
- Reading Hospital and Medical Center
- Geisinger Wyoming Valley Medical Center
- CCOP - MainLine Health
- Lankenau Cancer Center at Lankenau Hospital
- Bon Secours St. Francis Health System
- Greenville Hospital System Cancer Center
- CCOP - Greenville
- Rapid City Regional Hospital
- Sioux Valley Hospital and University of South Dakota Medical Center
- Avera McKennan Hospital and University Health Center
- Medical X-Ray Center
- Baptist Centers for Cancer Care
- Harrington Cancer Center
- St. Joseph Regional Cancer Center
- Brooke Army Medical Center
- M.D. Anderson Cancer Center at University of Texas
- Wilford Hall Medical Center
- Joe Arrington Cancer Research and Treatment Center
- Veterans Affairs Medical Center - San Antonio (Murphy)
- Cancer Therapy and Research Center
- University Hospital - San Antonio
- University of Texas Health Science Center at San Antonio
- Cottonwood Hospital Medical Center
- McKay-Dee Hospital Center
- Utah Valley Regional Medical Center - Provo
- Utah Cancer Specialists at UCS Cancer Center
- Huntsman Cancer Institute at University of Utah
- LDS Hospital
- Dixie Regional Medical Center
- Mountainview Medical
- Fletcher Allen Health Care - University Health Center Campus
- Danville Regional Medical Center
- Virginia Oncology Associates - Hampton
- Bon Secours Cancer Care at St. Mary's Hospital
- St. Joseph Hospital Community Cancer Center
- Olympic Hematology and Oncology
- Providence Cancer Institute at Providence Everett Medical Center - Pacific Campus
- Cancer Care Center at Skagit Valley Hospital
- CCOP - Virginia Mason Research Center
- Fred Hutchinson Cancer Research Center
- Group Health Central Hospital
- Harborview Medical Center
- Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
- University Cancer Center at University of Washington Medical Center
- Cancer Care Northwest - Spokane South
- Madigan Army Medical Center
- Cancer Center at Southwest Washington Medical Center
- Central Washington Hospital
- Wenatchee Valley Clinic
- Mary Babb Randolph Cancer Center at West Virginia University Hospitals
- Camden-Clark Memorial Hospital
- Luther Mildelfort Hospital
- Midelfort Clinic - Luther
- Central Wisconsin Cancer Program at Agnesian Health Care
- Green Bay Oncology, Limited at St. Vincent Hospital
- St. Vincent Hospital
- Green Bay Oncology, Limited at St. Mary's Hospital
- St. Mary's Hospital Medical Center
- Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
- University of Wisconsin Comprehensive Cancer Center
- Bay Area Cancer Care Center at Bay Area Medical Center
- Marshfield Clinic - Marshfield Center
- Community Memorial Hospital
- Vince Lombardi Cancer Clinic at St. Luke's Medical Center
- Medical College of Wisconsin Cancer Center
- Veterans Affairs Medical Center - Milwaukee (Zablocki)
- All Saints Cancer Center at All Saints Healthcare
- West Allis Memorial Hospital
- Pretoria Academic Hospital