Cisplatin Combined With Radiation Therapy and Hyperthermia in Treating Patients With Stage II, Stage III, or Stage IV Cervical Cancer
Cervical Cancer
About this trial
This is an interventional treatment trial for Cervical Cancer focused on measuring stage III cervical cancer, stage IIB cervical cancer, stage IVA cervical cancer, cervical squamous cell carcinoma, cervical adenocarcinoma, cervical adenosquamous cell carcinoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically or cytologically confirmed stage IIB-IVA carcinoma of the cervix Adenocarcinoma Squamous cell carcinoma Mixed cell histology No small cell anaplastic histology No para-aortic lymph node involvement No indication for para-aortic radiotherapy No distant metastases No CNS disease PATIENT CHARACTERISTICS: Age: 18 and over Performance status: WHO 0-2 Life expectancy: More than 3 months Hematopoietic: WBC at least 3,000/mm^3 Absolute neutrophil count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 Hemoglobin at least 7.0 mmol/L (approximately 11 g/dL) Epoetin alfa and/or transfusion allowed Hepatic: Not specified Renal: Glomerular filtration rate at least 60 mL/min Cardiovascular: No myocardial infarction within the past 6 months No unstable angina No congestive heart failure with expected inability to tolerate fluid load No cerebrovascular accident within the past 6 months Other: No pacemaker and/or metal implants No active uncontrolled infection No compromised immune status No psychosis No other prior malignancy except nonmelanoma skin cancer No mental or other physical inability that would preclude study PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: See Disease Characteristics No prior radiotherapy Surgery: No prior surgery
Sites / Locations
- Academisch Medisch Centrum
- University Hospital - Rotterdam Dijkzigt
- Rotterdam Cancer Institute
- Academisch Ziekenhuis Utrecht