Clinical and Chemical Outcomes Following Cardiac Surgery: The Post-Operative Effects of MUF (MUF)
Coronary Artery Disease, Anemia
About this trial
This is an interventional treatment trial for Coronary Artery Disease focused on measuring cardiovascular surgery, cardiac surgery, cardiopulmonary bypass, IV fluids, blood pressure, heart-lung machine, hemofilter, online MUF, offline MUF, modified ultrafiltration, multiple-pass hemofiltration, centrifugation method, blood transfusion, plasma proteins, post-cardiopulmonary bypass, hemoglobin, clotting factors, systemic blood pressure, cardiac index, cytokines, post-operative bleeding, protamine administration, patient size, allogeneic transfusion, total protein, albumin, vasoactive inotrope score, fluid balance, chest tube loss, length of stay, ventilation time, markers of inflammation
Eligibility Criteria
Inclusion Criteria:
- male and female
- patient weighs 75 kg or smaller
- 40-80 years of age
- elective or urgent cardiac surgery
Exclusion Criteria:
- emergent surgery
- severe anemia
- severe kidney dysfunction
- ejection fraction of less than 30%
Sites / Locations
- Royal University Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Control (CF)
Online MUF
Offline MUF
Centrifugation Method (CF): currently used to separate whole blood into red blood cells (RBCs) and plasma components. The RBCs are washed with normal saline and re-infused into the patient, while the plasma portion is discarded.
Online MUF: hemofilter is used online while the heart-lung machine is connected to the patient.
Offline MUF: hemofilter is used offline when the heart-lung machine is not connected to the patient.