Clinical Effects of Limosilactobacillus Reuteri Probiotics as an Adjunct to the Treatment of Periodontitis
Chronic Periodontitis, Generalized
About this trial
This is an interventional treatment trial for Chronic Periodontitis, Generalized focused on measuring probiotics, Limosilactobacillus reuteri
Eligibility Criteria
Inclusion Criteria: Patients over 18 years old, who intend to voluntarily participate in the study and: Have a definitive diagnosis of stage II, grade A, B or C, generalized periodontitis (2018, World Workshop); Have at least 3 natural teeth maintained per quadrant. Exclusion Criteria: • Patients unable to understand the instructions necessary to participate in the study or unable to give informed consent; Patients who have received any type of periodontal treatment 2 months prior to the start of study participation; Pregnant or breastfeeding patients; Patients with associated systemic pathology, such as diabetes, HIV, asthma, hyperthyroidism, immune system pathologies, lichen erosive or other pathologies treated with corticosteroids or immunosuppressants; Patients undergoing therapy with drugs that may interfere with the response of the gingival tissues: anti-inflammatory drugs, anticonvulsants (phenytoin and sodium valproate), immunosuppressants (cyclosporin-A and tacrolimus) and antihypertensives (nifedipine and verapamil hydrochloride); Patients undergoing anticoagulant therapy; Patients allergic to both lidocaine, articaine and mepivacaine; Patients who require antibiotic prophylaxis for bacterial endocarditis; Patients who have had antibiotic therapy within 2 months of study participation; Patients using chlorhexidine, or other mouthwashes or elixirs; Patients undergoing orthodontic treatment.
Sites / Locations
- Faculty of Dental Medicine - University of PortoRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Probiotics Lozenge
Negative control Lozenge
Subjects are instructed to take a lozenge twice a day, after brushing, in the morning and the evening.
Subjects are instructed to take a lozenge twice a day, after brushing, in the morning and the evening.