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Clinical Pathways for the Management of Acute Coronary Syndromes - Phase 3,CPACS-3 (CPACS-3)

Primary Purpose

Acute Coronary Syndromes

Status
Completed
Phase
Not Applicable
Locations
China
Study Type
Interventional
Intervention
quality improvement initiatives
Sponsored by
The George Institute for Global Health, China
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional health services research trial for Acute Coronary Syndromes focused on measuring Quality of care, Acute Coronary Syndromes (ACS)

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • admitted to participating hospitals
  • diagnosed as Acute Coronary Syndromes(ACS) at the time of death or discharge
  • aged 18 years or older

Exclusion Criteria:

  • death happened within 10 mins after arriving hospital
  • ACS happened during hospitalization due to other health problem
  • patients already registered in the database

Sites / Locations

  • Weining hospital
  • Lixin people's hospital
  • Woyang people's hospital
  • Wuwei people's hospital
  • Yingshang people's hospital
  • Linquan people's hospital
  • Suixi people's hospital
  • Shucheng people's hospital
  • Huoshang hospital
  • Zhuanglang people's hospital
  • Gaolan people's hospital
  • Jingning people's hospital
  • Zhuangliang people's hospital
  • Taishan people's hospital
  • Wuhua people's hospital
  • Lianzhou people's hospital
  • Wuchuan people's hospital
  • Pu'an people's hospital
  • Dejiang
  • Yuqing people's hospital
  • Gaoyang hospital
  • Tang county hospital
  • Yi county hospital
  • Weichang manchu mongolia atounomous county hospital
  • Quzhou hospital
  • Jizhou hospital
  • Qinglong hospital
  • Zanhuang hospital
  • Shenze hospital
  • Pingxiang people's hospital
  • Huaxian people's hospital
  • Wuzhi people's hospital
  • Ruyang people's hospital
  • Xixia people's hospital
  • Chang huan hong li hospital
  • Shangcheng people's hospital
  • Dancheng people's hospital
  • Pingyu people's hospital
  • Jianshi people's hospital
  • Songzi people's hospital
  • Danjiangkou's first hospital
  • Tongcheng people's hospital
  • Gucheng people's hospital
  • Yidu's first hospital
  • Yingcheng people's hospital
  • Zhongxiang people's hospital
  • Ba lin zuo qi people's hospital
  • A rong qi people's hospital
  • Zha lu te people's hospital
  • Huolinguole hospital
  • DongHai people's hospital
  • Dongtai people's hospital
  • Gaoyou people's hospital
  • Tongyu people's hospital
  • Linjiang hospital
  • Dong feng people's hospital
  • Qian'an hospital
  • Huinan people's hospital
  • Changbai montain protection and development zone central hospital
  • Hunchun people's hospital
  • Yitong 1st people's hospital
  • Beipiao 1st people's hospital
  • Lingyuan people's hospital
  • Zhuanghe central hospital
  • Wafangdian people's hospital
  • Kuandian Manchu Autonomous County Central Hospital
  • Qingyuan Manchu Autonomous County people's hospital
  • Beizhen people's hospital
  • Changtu people's hospital
  • Fengxiang hospital
  • Xixiang hospital
  • Mian county hospital
  • Fuping hospital
  • Hancheng people's hospital
  • Hu county hospital
  • Zichang hospital
  • Shenmu hospital
  • Chengwu people's hospital
  • Pingyin people's hospital
  • Dong'e people's hospital
  • Yinan people's hospital
  • Xintai people's hospital
  • Linqu people's hospital
  • Penglai people's hospital
  • Huantai people's hospital
  • Changzhi steel and iron group head hospital
  • Qingyuan people's hospital
  • Hunyuan people's hospital
  • Houma people's hospital
  • Gaoping people's hospital
  • Lingshi people's hospital
  • Pu xian people's hospital
  • Xiangfen people's hospital
  • Guxian people's hospital
  • Yicheng people's hospital
  • Lou fan people's hospital
  • Yuanping people's hospital
  • Huanqu people's hospital
  • Dazhu people's hospital
  • Cangxi people's hospital
  • Mianning people's hospital
  • Xuyong people's hospital

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm Type

Other

Other

Other

Other

Arm Label

Group 1

Group 2

Group 3

Group 4

Arm Description

Group 1 will receive quality improvement initiatives first, after 6 months of baseline initiation.

Group 2 will receive quality improvement initiatives second, after 6 months of the intervention initiation for Group 1.

Group 3 will receive quality improvement initiatives third, after 6 months of the intervention initiation for Group 2.

Group 4 will receive quality improvement initiatives forth, after 6 months of the intervention initiation for Group 3.

Outcomes

Primary Outcome Measures

incidence rate of in-hospital major adverse cardiovascular events (MACE)
In-hospital major adverse cardiovascular events (MACE) comprising all-cause mortality, myocardial infarction or recurrent myocardial infarction and non-fatal stroke.The in-hospital mortality will include patients who deid during hospitalization, patients who gave up treatment and home and die within 1 week after returning home, and patients transfer to superior hospitals but die within one day.

Secondary Outcome Measures

in-hospital all cause deaths
The in-hospital mortality will include patients who deid during hospitalization, patients who gave up treatment and home and die within 1 week after returning home, and patients transfer to superior hospitals but die within one day.
a patient level composite score calculated by KPIs of ACS care
A patient-level composite score is formed by dividing the total number of 15 pre-defined binary KPIs a patient receives by the total sum of KPIs a patient is eligible to receive. 15 KPI include: receive the first ECG within 10 minutes after arrival, receive aspirin within 24 hours of arrival, receive clopidogrel within 24 hours of arrival, receive statin within 24 hours of arrival, prescribe aspirin at discharge, prescribed clopidogrel at discharge, prescribed beta-blocker at discharge, prescribed statin at discharge, LVSD prescribed ACEI or ARB at discharge, STEMI that arrive hospital within 12 hours of symptom onset receive fibrinolysis, STEMI that received fibrinolytic therapy received this within 30 minutes of arrival, final diagnosis consistent with ECG and biomarker findings, receive both aspirin and clopidogrel within 24 hours, patient receive both aspirin and clopidogrel with loading dose within 24 hours, patient receive statin with loading dose within 24 hours.
each of the 16 KPIs (patient level)
receive the first ECG within 10 minutes after arrival, receive aspirin within 24 hours of arrival, receive clopidogrel within 24 hours of arrival, receive statin within 24 hours of arrival, prescribe aspirin at discharge, prescribed clopidogrel at discharge, prescribed beta-blocker at discharge, prescribed statin at discharge, LVSD prescribed ACEI or ARB at discharge, STEMI that arrive hospital within 12 hours of symptom onset receive fibrinolysis, STEMI that received fibrinolytic therapy received this within 30 minutes of arrival, final diagnosis consistent with ECG and biomarker findings, receive both aspirin and clopidogrel within 24 hours, patient receive both aspirin and clopidogrel with loading dose within 24 hours, patient receive statin with loading dose within 24 hours and length of stay.
a composite of MACE and re-hospitalization due to cardiovascular disease within 6 months after discharge

Full Information

First Posted
July 18, 2011
Last Updated
August 8, 2016
Sponsor
The George Institute for Global Health, China
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1. Study Identification

Unique Protocol Identification Number
NCT01398228
Brief Title
Clinical Pathways for the Management of Acute Coronary Syndromes - Phase 3,CPACS-3
Acronym
CPACS-3
Official Title
Clinical Pathways for the Management of Acute Coronary Syndromes - Phase 3
Study Type
Interventional

2. Study Status

Record Verification Date
August 2016
Overall Recruitment Status
Completed
Study Start Date
September 2011 (undefined)
Primary Completion Date
December 2014 (Actual)
Study Completion Date
June 2015 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
The George Institute for Global Health, China

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The burden of chronic, non-communicable disease, of which cardiovascular disease comprises a significant component, has increased rapidly and substantially in China over recent years. Over the coming decades China is predicted to experience a 69% increase in acute coronary disease(ACS), amounting to nearly 8 million additional events. A recent randomized trial of more than 15,000 patients with acute coronary syndromes, the second phase of Clinical Pathway for acute coronary syndromes in China (CPACS-2) study, showed that a quality improvement initiative could improve aspects of hospital care, including the proportion of patients discharged on appropriate medication. The study also identified a number of barriers to improved care including out of pocket costs and administration systems. However, the study was not able to determine the impact on clinical outcomes or the cost-effectiveness of the intervention. The aim of the third phase of the Clinical Pathway for acute coronary syndromes in China (CPACS-3) study is to determine whether a complex intervention comprising a clinical pathway for ACS management in combination with a number of physician and patient-oriented education tools can improve the quality of care and health outcomes among ACS patient admitted to resource-limited (provincial) hospitals. The effectiveness of the intervention will be evaluated using a cluster randomized trial (stepped wedge design) of ACS patients admitted to 104 hospitals in China. The study will incorporate two additional components (1) a qualitative substudy to identify the barriers and enablers to improved care and (2) a study comparing the cost-effectiveness of the intervention compared to usual care, from the perspective of the health care provider. The study will be conducted in conjunction with the Chinese Ministry of Health and the Chinese Society of Cardiology. The findings from CPACS3 will be able to inform health policy-makers about the extent to which quality improvement initiatives can reduce the risk of death and disability among the millions of ACS patients admitted to hospitals in China each year.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Acute Coronary Syndromes
Keywords
Quality of care, Acute Coronary Syndromes (ACS)

7. Study Design

Primary Purpose
Health Services Research
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
29934 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Group 1
Arm Type
Other
Arm Description
Group 1 will receive quality improvement initiatives first, after 6 months of baseline initiation.
Arm Title
Group 2
Arm Type
Other
Arm Description
Group 2 will receive quality improvement initiatives second, after 6 months of the intervention initiation for Group 1.
Arm Title
Group 3
Arm Type
Other
Arm Description
Group 3 will receive quality improvement initiatives third, after 6 months of the intervention initiation for Group 2.
Arm Title
Group 4
Arm Type
Other
Arm Description
Group 4 will receive quality improvement initiatives forth, after 6 months of the intervention initiation for Group 3.
Intervention Type
Behavioral
Intervention Name(s)
quality improvement initiatives
Intervention Description
A six component quality improvement intervention will be implemented. These components include: establishment of a quality improvement team, hospital performance audit and feedback, implementation of a clinical pathway, training of physicians and nurses, online technical support and patient education.
Primary Outcome Measure Information:
Title
incidence rate of in-hospital major adverse cardiovascular events (MACE)
Description
In-hospital major adverse cardiovascular events (MACE) comprising all-cause mortality, myocardial infarction or recurrent myocardial infarction and non-fatal stroke.The in-hospital mortality will include patients who deid during hospitalization, patients who gave up treatment and home and die within 1 week after returning home, and patients transfer to superior hospitals but die within one day.
Time Frame
from hospitaliztion to 1 week after discharge
Secondary Outcome Measure Information:
Title
in-hospital all cause deaths
Description
The in-hospital mortality will include patients who deid during hospitalization, patients who gave up treatment and home and die within 1 week after returning home, and patients transfer to superior hospitals but die within one day.
Time Frame
from hospitaliztion to 1 week after discharge
Title
a patient level composite score calculated by KPIs of ACS care
Description
A patient-level composite score is formed by dividing the total number of 15 pre-defined binary KPIs a patient receives by the total sum of KPIs a patient is eligible to receive. 15 KPI include: receive the first ECG within 10 minutes after arrival, receive aspirin within 24 hours of arrival, receive clopidogrel within 24 hours of arrival, receive statin within 24 hours of arrival, prescribe aspirin at discharge, prescribed clopidogrel at discharge, prescribed beta-blocker at discharge, prescribed statin at discharge, LVSD prescribed ACEI or ARB at discharge, STEMI that arrive hospital within 12 hours of symptom onset receive fibrinolysis, STEMI that received fibrinolytic therapy received this within 30 minutes of arrival, final diagnosis consistent with ECG and biomarker findings, receive both aspirin and clopidogrel within 24 hours, patient receive both aspirin and clopidogrel with loading dose within 24 hours, patient receive statin with loading dose within 24 hours.
Time Frame
During Hospitalization, an expected average of 10 days
Title
each of the 16 KPIs (patient level)
Description
receive the first ECG within 10 minutes after arrival, receive aspirin within 24 hours of arrival, receive clopidogrel within 24 hours of arrival, receive statin within 24 hours of arrival, prescribe aspirin at discharge, prescribed clopidogrel at discharge, prescribed beta-blocker at discharge, prescribed statin at discharge, LVSD prescribed ACEI or ARB at discharge, STEMI that arrive hospital within 12 hours of symptom onset receive fibrinolysis, STEMI that received fibrinolytic therapy received this within 30 minutes of arrival, final diagnosis consistent with ECG and biomarker findings, receive both aspirin and clopidogrel within 24 hours, patient receive both aspirin and clopidogrel with loading dose within 24 hours, patient receive statin with loading dose within 24 hours and length of stay.
Time Frame
During hospitalization, an expected average of 10 days
Title
a composite of MACE and re-hospitalization due to cardiovascular disease within 6 months after discharge
Time Frame
in 6 months after discharge

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: admitted to participating hospitals diagnosed as Acute Coronary Syndromes(ACS) at the time of death or discharge aged 18 years or older Exclusion Criteria: death happened within 10 mins after arriving hospital ACS happened during hospitalization due to other health problem patients already registered in the database
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Yangfeng Wu, PhD
Organizational Affiliation
George Institute for global health, China
Official's Role
Principal Investigator
Facility Information:
Facility Name
Weining hospital
City
Bijie
State/Province
Anhui
ZIP/Postal Code
553100
Country
China
Facility Name
Lixin people's hospital
City
Bozhou
State/Province
Anhui
ZIP/Postal Code
236700
Country
China
Facility Name
Woyang people's hospital
City
Bozhou
State/Province
Anhui
ZIP/Postal Code
236700
Country
China
Facility Name
Wuwei people's hospital
City
Chaohu
State/Province
Anhui
ZIP/Postal Code
238300
Country
China
Facility Name
Yingshang people's hospital
City
Fuyang
State/Province
Anhui
ZIP/Postal Code
236200
Country
China
Facility Name
Linquan people's hospital
City
Fuyang
State/Province
Anhui
ZIP/Postal Code
236400
Country
China
Facility Name
Suixi people's hospital
City
Huaibei
State/Province
Anhui
ZIP/Postal Code
235100
Country
China
Facility Name
Shucheng people's hospital
City
Liuan
State/Province
Anhui
ZIP/Postal Code
231300
Country
China
Facility Name
Huoshang hospital
City
Liuan
State/Province
Anhui
ZIP/Postal Code
237200
Country
China
Facility Name
Zhuanglang people's hospital
City
Dingxi
State/Province
Gansu
ZIP/Postal Code
730500
Country
China
Facility Name
Gaolan people's hospital
City
Lanzhou
State/Province
Gansu
ZIP/Postal Code
730200
Country
China
Facility Name
Jingning people's hospital
City
Pingliang
State/Province
Gansu
ZIP/Postal Code
743400
Country
China
Facility Name
Zhuangliang people's hospital
City
Pingliang
State/Province
Gansu
ZIP/Postal Code
744600
Country
China
Facility Name
Taishan people's hospital
City
Jiangmen
State/Province
Guangdong
ZIP/Postal Code
529200
Country
China
Facility Name
Wuhua people's hospital
City
Meizhou
State/Province
Guangdong
ZIP/Postal Code
514400
Country
China
Facility Name
Lianzhou people's hospital
City
Qingyuan
State/Province
Guangdong
ZIP/Postal Code
513300
Country
China
Facility Name
Wuchuan people's hospital
City
Zhanjiang
State/Province
Guangdong
ZIP/Postal Code
524500
Country
China
Facility Name
Pu'an people's hospital
City
Buwei
State/Province
Guizhou
ZIP/Postal Code
561500
Country
China
Facility Name
Dejiang
City
Tongren
State/Province
Guizhou
ZIP/Postal Code
565200
Country
China
Facility Name
Yuqing people's hospital
City
Zunyi
State/Province
Guizhou
ZIP/Postal Code
564400
Country
China
Facility Name
Gaoyang hospital
City
Baoding
State/Province
Hebei
ZIP/Postal Code
071500
Country
China
Facility Name
Tang county hospital
City
Baoding
State/Province
Hebei
ZIP/Postal Code
072300
Country
China
Facility Name
Yi county hospital
City
Baoding
State/Province
Hebei
ZIP/Postal Code
074200
Country
China
Facility Name
Weichang manchu mongolia atounomous county hospital
City
Chengde
State/Province
Hebei
ZIP/Postal Code
068400
Country
China
Facility Name
Quzhou hospital
City
Handan
State/Province
Hebei
ZIP/Postal Code
057200
Country
China
Facility Name
Jizhou hospital
City
Jizhou
State/Province
Hebei
ZIP/Postal Code
053200
Country
China
Facility Name
Qinglong hospital
City
Qinhuangdao
State/Province
Hebei
ZIP/Postal Code
066500
Country
China
Facility Name
Zanhuang hospital
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
051200
Country
China
Facility Name
Shenze hospital
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
052500
Country
China
Facility Name
Pingxiang people's hospital
City
Xingtai
State/Province
Hebei
ZIP/Postal Code
054500
Country
China
Facility Name
Huaxian people's hospital
City
Anyang
State/Province
Henan
ZIP/Postal Code
456400
Country
China
Facility Name
Wuzhi people's hospital
City
Jiaozuo
State/Province
Henan
ZIP/Postal Code
454950
Country
China
Facility Name
Ruyang people's hospital
City
Luoyang
State/Province
Henan
ZIP/Postal Code
471200
Country
China
Facility Name
Xixia people's hospital
City
Nanyang
State/Province
Henan
ZIP/Postal Code
474500
Country
China
Facility Name
Chang huan hong li hospital
City
Xinxiang
State/Province
Henan
ZIP/Postal Code
453000
Country
China
Facility Name
Shangcheng people's hospital
City
Xinyang
State/Province
Henan
ZIP/Postal Code
465300
Country
China
Facility Name
Dancheng people's hospital
City
Zhoukou
State/Province
Henan
ZIP/Postal Code
477100
Country
China
Facility Name
Pingyu people's hospital
City
Zhumadian
State/Province
Henan
ZIP/Postal Code
463400
Country
China
Facility Name
Jianshi people's hospital
City
Enshi
State/Province
Hubei
ZIP/Postal Code
445300
Country
China
Facility Name
Songzi people's hospital
City
Jinzhou
State/Province
Hubei
ZIP/Postal Code
434200
Country
China
Facility Name
Danjiangkou's first hospital
City
Shiyan
State/Province
Hubei
ZIP/Postal Code
442700
Country
China
Facility Name
Tongcheng people's hospital
City
Xian'ning
State/Province
Hubei
ZIP/Postal Code
437400
Country
China
Facility Name
Gucheng people's hospital
City
Xiangfan
State/Province
Hubei
ZIP/Postal Code
441700
Country
China
Facility Name
Yidu's first hospital
City
Yichang
State/Province
Hubei
ZIP/Postal Code
443300
Country
China
Facility Name
Yingcheng people's hospital
City
Yingcheng
State/Province
Hubei
ZIP/Postal Code
432400
Country
China
Facility Name
Zhongxiang people's hospital
City
Zhongxiang
State/Province
Hubei
ZIP/Postal Code
431900
Country
China
Facility Name
Ba lin zuo qi people's hospital
City
Chifeng
State/Province
Inner Mongolia
ZIP/Postal Code
025400
Country
China
Facility Name
A rong qi people's hospital
City
Hulin
State/Province
Inner Mongolia
ZIP/Postal Code
162700
Country
China
Facility Name
Zha lu te people's hospital
City
Tongliao
State/Province
Inner Mongolia
ZIP/Postal Code
029100
Country
China
Facility Name
Huolinguole hospital
City
Tongliao
State/Province
Inner Mongolia
ZIP/Postal Code
029200
Country
China
Facility Name
DongHai people's hospital
City
Lianyungang
State/Province
Jiangsu
ZIP/Postal Code
222300
Country
China
Facility Name
Dongtai people's hospital
City
Yancheng
State/Province
Jiangsu
ZIP/Postal Code
224200
Country
China
Facility Name
Gaoyou people's hospital
City
Yangzhou
State/Province
Jiangsu
ZIP/Postal Code
225600
Country
China
Facility Name
Tongyu people's hospital
City
Baicheng
State/Province
Jilin
ZIP/Postal Code
137000
Country
China
Facility Name
Linjiang hospital
City
Baishan
State/Province
Jilin
ZIP/Postal Code
134600
Country
China
Facility Name
Dong feng people's hospital
City
Liaoyuan
State/Province
Jilin
ZIP/Postal Code
136300
Country
China
Facility Name
Qian'an hospital
City
Songyuan
State/Province
Jilin
ZIP/Postal Code
131400
Country
China
Facility Name
Huinan people's hospital
City
Tonghua
State/Province
Jilin
ZIP/Postal Code
135100
Country
China
Facility Name
Changbai montain protection and development zone central hospital
City
Yanbian
State/Province
Jilin
ZIP/Postal Code
133000
Country
China
Facility Name
Hunchun people's hospital
City
Yanbian
State/Province
Jilin
ZIP/Postal Code
133300
Country
China
Facility Name
Yitong 1st people's hospital
City
Yitong
State/Province
Jilin
ZIP/Postal Code
130700
Country
China
Facility Name
Beipiao 1st people's hospital
City
Chaoyang
State/Province
Liaoning
ZIP/Postal Code
122000
Country
China
Facility Name
Lingyuan people's hospital
City
Chaoyang
State/Province
Liaoning
ZIP/Postal Code
122500
Country
China
Facility Name
Zhuanghe central hospital
City
Dalian
State/Province
Liaoning
ZIP/Postal Code
116200
Country
China
Facility Name
Wafangdian people's hospital
City
Dalian
State/Province
Liaoning
ZIP/Postal Code
116300
Country
China
Facility Name
Kuandian Manchu Autonomous County Central Hospital
City
Dandong
State/Province
Liaoning
ZIP/Postal Code
118200
Country
China
Facility Name
Qingyuan Manchu Autonomous County people's hospital
City
Fushun
State/Province
Liaoning
ZIP/Postal Code
113300
Country
China
Facility Name
Beizhen people's hospital
City
Jinzhou
State/Province
Liaoning
ZIP/Postal Code
122000
Country
China
Facility Name
Changtu people's hospital
City
Tieling
State/Province
Liaoning
ZIP/Postal Code
112500
Country
China
Facility Name
Fengxiang hospital
City
Baoji
State/Province
Shaanxi
ZIP/Postal Code
721400
Country
China
Facility Name
Xixiang hospital
City
Hanzhong
State/Province
Shaanxi
ZIP/Postal Code
723500
Country
China
Facility Name
Mian county hospital
City
Hanzhong
State/Province
Shaanxi
ZIP/Postal Code
724200
Country
China
Facility Name
Fuping hospital
City
Weinan
State/Province
Shaanxi
ZIP/Postal Code
711700
Country
China
Facility Name
Hancheng people's hospital
City
Weinan
State/Province
Shaanxi
ZIP/Postal Code
714200
Country
China
Facility Name
Hu county hospital
City
Xi'an
State/Province
Shaanxi
ZIP/Postal Code
710300
Country
China
Facility Name
Zichang hospital
City
Yan'an
State/Province
Shaanxi
ZIP/Postal Code
717300
Country
China
Facility Name
Shenmu hospital
City
Yulin
State/Province
Shaanxi
ZIP/Postal Code
719300
Country
China
Facility Name
Chengwu people's hospital
City
Heze
State/Province
Shandong
ZIP/Postal Code
274200
Country
China
Facility Name
Pingyin people's hospital
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250400
Country
China
Facility Name
Dong'e people's hospital
City
Liaocheng
State/Province
Shandong
ZIP/Postal Code
252200
Country
China
Facility Name
Yinan people's hospital
City
Linyi
State/Province
Shandong
ZIP/Postal Code
276300
Country
China
Facility Name
Xintai people's hospital
City
Tai'an
State/Province
Shandong
ZIP/Postal Code
271200
Country
China
Facility Name
Linqu people's hospital
City
Weifang
State/Province
Shandong
ZIP/Postal Code
262600
Country
China
Facility Name
Penglai people's hospital
City
Yantai
State/Province
Shandong
ZIP/Postal Code
265600
Country
China
Facility Name
Huantai people's hospital
City
Zibo
State/Province
Shandong
ZIP/Postal Code
256400
Country
China
Facility Name
Changzhi steel and iron group head hospital
City
Changzhi
State/Province
Shanxi
ZIP/Postal Code
046000
Country
China
Facility Name
Qingyuan people's hospital
City
Changzhi
State/Province
Shanxi
ZIP/Postal Code
046500
Country
China
Facility Name
Hunyuan people's hospital
City
Datong
State/Province
Shanxi
ZIP/Postal Code
037400
Country
China
Facility Name
Houma people's hospital
City
Houma
State/Province
Shanxi
ZIP/Postal Code
043000
Country
China
Facility Name
Gaoping people's hospital
City
Jincheng
State/Province
Shanxi
ZIP/Postal Code
048400
Country
China
Facility Name
Lingshi people's hospital
City
Jinzhong
State/Province
Shanxi
ZIP/Postal Code
031300
Country
China
Facility Name
Pu xian people's hospital
City
Linfen
State/Province
Shanxi
ZIP/Postal Code
041200
Country
China
Facility Name
Xiangfen people's hospital
City
Linfen
State/Province
Shanxi
ZIP/Postal Code
041500
Country
China
Facility Name
Guxian people's hospital
City
Linfen
State/Province
Shanxi
ZIP/Postal Code
042400
Country
China
Facility Name
Yicheng people's hospital
City
Linfen
State/Province
Shanxi
ZIP/Postal Code
043500
Country
China
Facility Name
Lou fan people's hospital
City
Taiyuan
State/Province
Shanxi
ZIP/Postal Code
030300
Country
China
Facility Name
Yuanping people's hospital
City
Xinzhou
State/Province
Shanxi
ZIP/Postal Code
034100
Country
China
Facility Name
Huanqu people's hospital
City
Yuncheng
State/Province
Shanxi
ZIP/Postal Code
043700
Country
China
Facility Name
Dazhu people's hospital
City
Dazhou
State/Province
Sichuan
ZIP/Postal Code
635100
Country
China
Facility Name
Cangxi people's hospital
City
Guangyuan
State/Province
Sichuan
ZIP/Postal Code
628400
Country
China
Facility Name
Mianning people's hospital
City
Liangshan
State/Province
Sichuan
ZIP/Postal Code
615600
Country
China
Facility Name
Xuyong people's hospital
City
Luzhou
State/Province
Sichuan
ZIP/Postal Code
464400
Country
China

12. IPD Sharing Statement

Citations:
PubMed Identifier
33465135
Citation
Xie W, Patel A, Boersma E, Feng L, Li M, Gao R, Wu Y. Chronic kidney disease and the outcomes of fibrinolysis for ST-segment elevation myocardial infarction: A real-world study. PLoS One. 2021 Jan 19;16(1):e0245576. doi: 10.1371/journal.pone.0245576. eCollection 2021.
Results Reference
derived
PubMed Identifier
32223960
Citation
Sun Y, Feng L, Li X, Gao R, Wu Y. The sex difference in 6-month MACEs and its explaining variables in acute myocardial infarction survivors: Data from CPACS-3 study. Int J Cardiol. 2020 Jul 15;311:1-6. doi: 10.1016/j.ijcard.2020.03.043. Epub 2020 Mar 20.
Results Reference
derived
PubMed Identifier
31712344
Citation
Feng L, Li M, Xie W, Zhang A, Lei L, Li X, Gao R, Wu Y. Prehospital and in-hospital delays to care and associated factors in patients with STEMI: an observational study in 101 non-PCI hospitals in China. BMJ Open. 2019 Nov 10;9(11):e031918. doi: 10.1136/bmjopen-2019-031918.
Results Reference
derived
PubMed Identifier
30994898
Citation
Wu Y, Li S, Patel A, Li X, Du X, Wu T, Zhao Y, Feng L, Billot L, Peterson ED, Woodward M, Kong L, Huo Y, Hu D, Chalkidou K, Gao R; CPACS-3 Investigators. Effect of a Quality of Care Improvement Initiative in Patients With Acute Coronary Syndrome in Resource-Constrained Hospitals in China: A Randomized Clinical Trial. JAMA Cardiol. 2019 May 1;4(5):418-427. doi: 10.1001/jamacardio.2019.0897.
Results Reference
derived
PubMed Identifier
25728724
Citation
Li S, Wu Y, Du X, Li X, Patel A, Peterson ED, Turnbull F, Lo S, Billot L, Laba T, Gao R; CPACS-3 investigators. Rational and design of a stepped-wedge cluster randomized trial evaluating quality improvement initiative for reducing cardiovascular events among patients with acute coronary syndromes in resource-constrained hospitals in China. Am Heart J. 2015 Mar;169(3):349-55. doi: 10.1016/j.ahj.2014.12.005. Epub 2014 Dec 18.
Results Reference
derived

Learn more about this trial

Clinical Pathways for the Management of Acute Coronary Syndromes - Phase 3,CPACS-3

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