Colectomy Reconstruction for Ulcerative Colitis, Ileorectal Anastomosis vs Ileal Pouch-Anal Anastomosis in Ulcerative Colitis. (CRUISE)
Ulcerative Colitis, Inflammatory Bowel Diseases, Ileostomy - Stoma
About this trial
This is an interventional treatment trial for Ulcerative Colitis focused on measuring Ulcerative Colitis,, Colectomy, Reconstruction
Eligibility Criteria
Inclusion criteria: Patients with Ulcerative colitis (UC) aged between 18 and 60 Scheduled for or have previously undergone subtotal colectomy and ileostomy. Patients should have sufficient rectal compliance and controllable inflammation in the rectal using topical Mezalasin only. Exclusion criteria Rectal inflammation of Mayo Score >1 Poor sphincter function, perianal disease Uncertainty regarding UC diagnosis P Previous colorectal cancer or severe dysplasia Primary Sclerosing Colitis diagnosis >2 year since subtotal colectomy
Sites / Locations
- Sahlgrenska Univercity HospitalRecruiting
- Linkoeping University hospitalRecruiting
- Karolinska University HospitalRecruiting
- St. Mark's HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Active Comparator
Active Comparator
Active Comparator
IPAA CRUISE
IRA CRUISE
IRA Control
IPAA Control
Ileostomy Control
Patients eligible for both operations choosing ileal pouch anal anastomosis.
Patients eligible for both operations choosing ileorectal anastomosis.
Patients only eligible for ileorectal anastomosis.
Patients only eligible for ileal pouch anal anastomosis.
Patients who decline reconstruction.