Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Relapsed or Refractory Hodgkin's Lymphoma
Lymphoma
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring stage I adult Hodgkin lymphoma, stage II adult Hodgkin lymphoma, stage III adult Hodgkin lymphoma, stage IV adult Hodgkin lymphoma, recurrent adult Hodgkin lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically proven stage I-IV Hodgkin's lymphoma Must have refractory or relapsed disease, defined by 1 of the following: Failure to achieve a complete remission (CR) after 4 courses of conventional-dose front-line chemotherapy Disease in second or greater remission Patients should be encouraged to undergo transplantation prior to a third salvage regimen Patients previously treated with multiple regimens considered on a case-by-case basis No chemoresistant disease, defined as active progression with tumor growth greater than 25% by volume during first-line chemotherapy Patients who respond to second-line chemotherapy may be eligible Stable residual masses after conventional-dose chemotherapy not considered treatment failures Active (refractory or relapsed) disease must be proven histologically or documented by gallium nitrate uptake Syngeneic marrow transplantation offered to patients with consenting identical twin donor No CNS involvement by lymphoma PATIENT CHARACTERISTICS: Age: 15 to 60 (selected patients up to age 70 may be eligible) Performance status: ECOG 0-2 Life expectancy: Not specified Hematopoietic: WBC greater than 4,000/mm^3 Absolute neutrophil count greater than 2,000/mm^3 Platelet count greater than 100,000/mm^3 Hepatic: Bilirubin less than 2.0 mg/dL SGOT and SGPT less than 2 times upper limit of normal Albumin greater than 3.0 g/dL Renal: Must meet 1 of the following criteria: Creatinine less than 1.8 mg/dL Creatinine clearance greater than 60 mL/min BUN less than 20 mg/dL Cardiovascular: Left ventricular ejection fraction at least 50% Pulmonary: DLCO, FEV_1, and FVC greater than 50% of predicted OR Resting pO_2 greater than 70 mm Hg on room air Other: HIV negative No severe neurologic or emotional disorders No active infection No other disease that would limit life expectancy Not pregnant Fertile patients must use effective contraception Adequate psychosocial support required PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy See Disease Characteristics Endocrine therapy Not specified Radiotherapy Not specified Surgery Not specified
Sites / Locations
- Fox Chase - Temple Cancer Center