Combination Chemotherapy in Treating Patients With Aggressive Non-Hodgkin's Lymphoma
Lymphoma
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring stage I grade 3 follicular lymphoma, stage I adult diffuse mixed cell lymphoma, stage I adult diffuse large cell lymphoma, stage I adult immunoblastic large cell lymphoma, stage III grade 3 follicular lymphoma, stage III adult diffuse mixed cell lymphoma, stage III adult diffuse large cell lymphoma, stage III adult immunoblastic large cell lymphoma, stage IV grade 3 follicular lymphoma, stage IV adult diffuse mixed cell lymphoma, stage IV adult diffuse large cell lymphoma, stage IV adult immunoblastic large cell lymphoma, contiguous stage II grade 3 follicular lymphoma, contiguous stage II adult diffuse mixed cell lymphoma, contiguous stage II adult immunoblastic large cell lymphoma, contiguous stage II adult diffuse large cell lymphoma, noncontiguous stage II grade 3 follicular lymphoma, noncontiguous stage II adult diffuse mixed cell lymphoma, noncontiguous stage II adult immunoblastic large cell lymphoma, noncontiguous stage II adult diffuse large cell lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically proven previously untreated bulky stage IA or stage IB-IV aggressive non-Hodgkin's lymphoma of 1 of the following types: Working formulation: Follicular large cell Diffuse mixed cell Diffuse large cell Diffuse immunoblastic OR REAL classification: Diffuse large B-cell Peripheral T-cell Measurable or evaluable disease Good prognosis defined as no more than one of the following: Stage III/IV disease LDH greater than upper limit of normal ECOG/WHO 2-4 No lymphoblastic or Burkitt's lymphoma No CNS involvement PATIENT CHARACTERISTICS: Age: 18 to 59 Performance status: See Disease Characteristics Life expectancy: Not specified Hematopoietic: Hemoglobin at least 10 g/dL Neutrophil count at least 2,000/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin, AST, and ALT no greater than 1.5 times upper limit of normal Renal: Creatinine no greater than 1.7 mg/dL Cardiovascular: Ejection fraction at least 50% unless dysfunction attributable to lymphoma Other: Not pregnant or nursing Fertile patients must use effective contraception No other concurrent serious uncontrolled medical conditions No other prior malignancy except adequately treated nonmelanoma skin cancer or cervical intraepithelial neoplasia PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy to more than 35% of hematopoietic sites Concurrent consolidation radiotherapy allowed Surgery: Not specified
Sites / Locations
- Stoke Mandeville Hospital
- Horton Hospital
- Basildon University Hospital
- Birmingham Heartlands Hospital
- Bradford Hospitals NHS Trust
- Bristol Haematology and Oncology Centre
- Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust
- Cheltenham General Hospital
- Countess of Chester Hospital NHS Foundation Trust
- Saint Richards Hospital
- Essex County Hospital
- Walsgrave Hospital
- Russells Hall Hospital
- Chase Farm Hospital
- Medway Maritime Hospital
- Hull Royal Infirmary
- Hinchingbrooke Hospital
- Queen Elizabeth Hospital
- Leicester Royal Infirmary
- Royal Liverpool and Broadgreen Hospitals NHS Trust
- Aintree University Hospital
- Saint Bartholomew's Hospital
- St. Thomas' Hospital
- St. George's Hospital
- Middlesex Hospital
- Clatterbridge Centre for Oncology NHS Trust
- Norfolk and Norwich University Hospital
- Nottingham City Hospital NHS Trust
- Oxford Radcliffe Hospital
- Pontefract General Infirmary
- Oldchurch Hospital
- Scunthorpe General Hospital
- Cancer Research Centre at Weston Park Hospital
- Southampton University Hospital NHS Trust
- University Hospital of North Staffordshire
- East Surrey Hospital
- Royal Marsden NHS Foundation Trust - Surrey
- Sandwell General Hospital
- Cancer Care Centre at York Hospital
- Centre for Cancer Research and Cell Biology at Belfast City Hospital
- Aberdeen Royal Infirmary
- Pinderfields Hospital NHS Trust
- Ysbyty Gwynedd
- University Hospital of Wales
- Glan Clywd District General Hospital
- Mount Vernon Cancer Centre at Mount Vernon Hospital