Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia
Leukemia, Lymphoma
About this trial
This is an interventional treatment trial for Leukemia focused on measuring childhood Burkitt lymphoma, L3 childhood acute lymphoblastic leukemia, B-cell childhood acute lymphoblastic leukemia, L3 adult acute lymphoblastic leukemia, B-cell adult acute lymphoblastic leukemia, stage III adult Burkitt lymphoma, stage IV adult Burkitt lymphoma, stage III childhood small noncleaved cell lymphoma, stage IV childhood small noncleaved cell lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: One of the following diagnoses: Histologically confirmed small noncleaved cell non-Hodgkin's lymphoma Stage III or IV Burkitt's or non-Burkitt's by the Working Formulation OR Burkitt's or Burkitt's-like by the REAL classification Histologically confirmed B-cell acute lymphocytic leukemia At least 25% blasts in bone marrow FAB L3 morphology FAB L1 morphology allowed if blasts show B-cell markers (CD19, 20, 22) and surface immunoglobulin positivity Must be registered on POG-9900 in past 8 days PATIENT CHARACTERISTICS: Age: Under 22 at time of diagnosis Performance status: Not specified Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified Other: Not pregnant or nursing Negative pregnancy test HIV positive allowed PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Not specified Endocrine therapy: No concurrent use of dexamethasone as antiemetic Radiotherapy: Not specified Surgery: Prior surgery allowed Other: No prior therapy except surgery
Sites / Locations
- University of Alabama at Birmingham Comprehensive Cancer Center
- University of South Alabama Medical Center
- MBCCOP - Gulf Coast
- Arizona Cancer Center
- University of Arkansas for Medical Sciences
- University of California San Diego Cancer Center
- Lucile Packard Children's Hospital at Stanford
- Sutter Cancer Center
- University of California Davis Medical Center
- Kaiser Permanente-Southern California Permanente Medical Group
- Children's Hospital and Health Center
- Kaiser Permanente Medical Center - Santa Clara
- Yale Comprehensive Cancer Center
- Walter Reed Army Medical Center
- Broward General Medical Center
- Children's Hospital of Southwest Florida
- Shands Hospital and Clinics, University of Florida
- Nemours Children's Clinic
- Sylvester Cancer Center, University of Miami
- University of Miami-Jackson Memorial Hospital Medical Center
- Miami Children's Hospital
- Baptist Hospital of Miami
- Florida Hospital Cancer Institute
- All Children's Hospital
- CCOP - Florida Pediatric
- St. Mary's Hospital
- Emory University Hospital - Atlanta
- Emory University School of Medicine
- Cancer Research Center of Hawaii
- Tripler Army Medical Center
- Rush-Presbyterian-St. Luke's Medical Center
- Children's Memorial Hospital, Chicago
- Hope Children's Hospital
- CCOP - Illinois Oncology Research Association
- Saint Jude Midwest Affiliate
- University of Kansas Medical Center
- CCOP - Wichita
- Via Christi Regional Medical Center
- MBCCOP - LSU Health Sciences Center
- Tulane University School of Medicine
- CCOP - Ochsner
- Eastern Maine Medical Center
- Maine Children's Cancer Program
- Marlene & Stewart Greenebaum Cancer Center, University of Maryland
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Boston Floating Hospital Infants and Children
- Massachusetts General Hospital Cancer Center
- Dana-Farber Cancer Institute
- University of Massachusetts Memorial Medical Center
- Children's Hospital of Michigan
- St. John Hospital and Medical Center
- Hurley Medical Center
- University of Mississippi Medical Center
- Keesler Medical Center - Keesler AFB
- University of Missouri-Columbia Hospital and Clinics
- Cardinal Glennon Children's Hospital
- Washington University School of Medicine
- Norris Cotton Cancer Center
- CCOP - Northern New Jersey
- Hackensack University Medical Center
- University of New Mexico School of Medicine
- Roswell Park Cancer Institute
- Schneider Children's Hospital
- Mount Sinai School of Medicine
- University of Rochester Cancer Center
- State University of New York Health Sciences Center - Stony Brook
- State University of New York - Upstate Medical University
- Mission Saint Joseph's Health System
- Carolinas Medical Center
- Presbyterian Healthcare
- Duke Comprehensive Cancer Center
- East Carolina University School of Medicine
- Comprehensive Cancer Center at Wake Forest University
- Oklahoma Memorial Hospital
- Natalie Warren Bryant Cancer Center
- CCOP - Columbia River Program
- Legacy Emanuel Hospital and Health Center
- St. Christopher's Hospital for Children
- Medical University of South Carolina
- Children's Hospital of Greenville Hospital System
- James H. Quillen College of Medicine
- Saint Jude Children's Research Hospital
- Driscoll Children's Hospital
- Texas Oncology P.A.
- Medical City Dallas Hospital
- Simmons Cancer Center - Dallas
- Cook Children's Medical Center - Fort Worth
- University of Texas Medical Branch
- Baylor College of Medicine
- San Antonio Military Pediatric Cancer and Blood Disorders Center
- MBCCOP - South Texas Pediatric
- University of Texas Health Science Center at San Antonio
- Scott and White Clinic
- Vermont Cancer Center
- Cancer Center at the University of Virginia
- Inova Fairfax Hospital
- Naval Medical Center, Portsmouth
- Massey Cancer Center
- Carilion Roanoke Community Hospital
- Madigan Army Medical Center
- West Virginia University Medical School-Charleston
- West Virginia University Hospitals
- St. Vincent Hospital
- Midwest Children's Cancer Center
- Royal Children's Hospital
- Alberta Children's Hospital
- Cross Cancer Institute
- Children's Hospital
- Children's Hospital of Eastern Ontario
- Hospital for Sick Children
- McGill University Health Center - Montreal Children's Hospital
- Hopital Sainte Justine
- Centre Hospitalier de L'Universite Laval
- Laval University Medical Center
- Academisch Ziekenhuis Groningen
- San Jorge Childrens Hospital
- Swiss Pediatric Oncology Group Bern
- Clinique de Pediatrie
- Centre Hospitalier Universitaire Vaudois
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Experimental
Experimental
Experimental
STAGE III NHL (Trt 1)
STAGE IV NHL, -CNS (Trt 2)
STAGE IV, +CNS (Trt 3)
B-ALL, -CNS (Trt 2)
B-ALL, +CNS (Trt 3)
A: Cyclophosphamide (CTX), Doxorubicin hydrochloride, Vincristine sulfate (VCR), Dexamethasone IT Therapy. B: HD-Methotrexate(MTX), Cytarabine(Ara-C), Dexamethasone IT Therapy. Treatment ABABA
A: Cyclophosphamide (CTX), Doxorubicin hydrochloride, Vincristine sulfate (VCR), Dexamethasone IT Therapy. B: HD-Methotrexate(MTX), Cytarabine(Ara-C), Dexamethasone IT Therapy. Treatment ABABAB
A: Cyclophosphamide (CTX), Doxorubicin hydrochloride, Vincristine sulfate (VCR), Dexamethasone IT Therapy. B: HD-Methotrexate(MTX), Cytarabine(Ara-C), Dexamethasone IT Therapy. C: Etoposide, Ifosfamide, Dexamethasone IT Therapy. Treatment ABCABAB
A: Cyclophosphamide (CTX), Doxorubicin hydrochloride, Vincristine sulfate (VCR), Dexamethasone IT Therapy. B: HD-Methotrexate(MTX), Cytarabine(Ara-C), Dexamethasone IT Therapy. Treatment ABABAB
A: Cyclophosphamide (CTX), Doxorubicin hydrochloride, Vincristine sulfate (VCR), Dexamethasone IT Therapy. B: HD-Methotrexate(MTX), Cytarabine(Ara-C), Dexamethasone IT Therapy. C: Etoposide, Ifosfamide, Dexamethasone IT Therapy. Treatment ABCABAB