Combination Chemotherapy in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer
Lung Cancer
About this trial
This is an interventional treatment trial for Lung Cancer focused on measuring adenosquamous cell lung cancer, bronchoalveolar cell lung cancer, large cell lung cancer, recurrent non-small cell lung cancer, squamous cell lung cancer, stage IIIB non-small cell lung cancer, stage IV non-small cell lung cancer, adenocarcinoma of the lung
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed non-small cell lung cancer (NSCLC) of 1 of the following types: Squamous cell Adenocarcinoma Large cell anaplastic Bronchoalveolar Non-small cell carcinoma not otherwise specified NOTE: Mixed tumors are categorized by the predominant cell type (tumors with small-cell anaplastic elements are ineligible) Evidence of at least 1 of the following: Clinically documented recurrent disease after prior radiation or surgery Stage IV disease (distant metastases) Stage IIIB disease presenting with 1 of the following: Pleural or pericardial effusion by CT scan or chest x-ray Pleural implants documented pathologically or seen on CT scan or x-ray Measurable or evaluable disease No brain metastases unless clinically stable after surgery and/or radiotherapy PATIENT CHARACTERISTICS: Age 18 and over Performance status ECOG 0-1 Life expectancy Not specified Hematopoietic Absolute neutrophil count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 Hepatic Bilirubin no greater than 1.5 mg/dL AST less than 5 times upper limit of normal Renal Creatinine no greater than 1.5 mg/dL OR Creatinine clearance at least 40 mL/min Other Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No hypersensitivity to agents that contain Cremophor EL (polyoxyethylated castor oil) PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy No prior chemotherapy for advanced NSCLC Endocrine therapy Not specified Radiotherapy See Disease Characteristics Recovered from prior radiotherapy No prior radiotherapy to the only site of measurable disease, unless the site had subsequent progression of disease documented by physical exam, radiography, or pathology No concurrent radiotherapy (except for brain metastases) Surgery See Disease Characteristics Other No concurrent aminoglycoside antibiotics
Sites / Locations
- Loma Linda University Cancer Institute at Loma Linda University Medical Center
- New Hope Cancer and Research Institute - Pomona
- Lawrence and Memorial Hospital
- University of Florida Shands Cancer Center
- Lakeland Regional Cancer Center at Lakeland Regional Medical Center
- Gulf Coast Cancer Treatment Center
- Veterans Affairs Medical Center - Atlanta (Decatur)
- Ingalls Cancer Care Center at Ingalls Memorial Hospital
- Carle Cancer Center at Carle Foundation Hospital
- Cancer Center of Indiana
- CCOP - Northern Indiana CR Consortium
- Annapolis Oncology Center
- Greenebaum Cancer Center at University of Maryland Medical Center
- Greater Baltimore Medical Center Cancer Center
- Baystate Regional Cancer Program at D'Amour Center for Cancer Care
- Fallon Clinic at Worcester Medical Center
- West Michigan Cancer Center
- Sletten Regional Cancer Institute at Benefis Healthcare
- Hunterdon Regional Cancer Center at Hunterdon Medical Center
- Jersey Shore Cancer Center at Jersey Shore University Medical Center
- AtlantiCare Regional Medical Center
- Mercer Bucks Oncology-Hematology
- Roswell Park Cancer Institute
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
- Cape Fear Valley Medical Center
- Leo W. Jenkins Cancer Center at ECU Medical School
- Aultman Hospital Cancer Center at Aultman Health Foundation
- Cleveland Clinic Cancer Center at Fairview Hospital
- Cleveland Clinic Taussig Cancer Center
- Parma Community General Hospital
- Rosenfeld Cancer Center at Abington Memorial Hospital
- Falling Spring Medical Associates
- Hematology-Oncology Associates of Northeastern Pennsylvania
- PinnacleHealth Regional Cancer Center at Polyclinic Hospital
- Richard G. Laube Cancer Center at ACMH
- Lancaster Cancer Center
- Central Pennsylvania Hematology and Medical Oncology Associates, PC
- Paoli Hematology-Oncology PC at Paoli Memorial Hospital
- Hahnemann University Hospital
- Drexel University College of Medicine - Center City Hahnemann Campus
- Fox Chase Cancer Center CCOP Research Base
- Pennsylvania Oncology Hematology Associates, Incorporated - Philadelphia
- Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
- Allegheny Cancer Center at Allegheny General Hospital
- Hillman Cancer Center at University of Pittsburgh Cancer Institute
- Pottstown Memorial Regional Cancer Center
- St. Joseph Medical Center
- Lankenau Cancer Center at Lankenau Hospital
- South Carolina Oncology Associates, PA
- Coastal Cancer Center - Myrtle Beach
- Family Cancer Center, PLLC - Collierville
- Baptist Regional Cancer Center at Baptist Hospital of East Tennessee
- University of Virginia Cancer Center at UV Health System
- David Lee Outpatient Cancer Center at Charleston Area Medical Center
- Morgantown Internal Medicine Group, Incorporated
- Mary Babb Randolph Cancer Center at West Virginia University Hospitals