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Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors

Primary Purpose

Childhood Renal Cell Carcinoma, Clear Cell Renal Cell Carcinoma, Clear Cell Sarcoma of the Kidney

Status

Completed

Phase

Phase 2

Locations

International

Study Type

Interventional

Intervention

Doxorubicin Hydrochloride

Irinotecan Hydrochloride

Conventional Surgery

Cyclophosphamide

Etoposide

Carboplatin

Dactinomycin

Vincristine Sulfate

Radiation Therapy

Laboratory Biomarker Analysis

About this trial

This is an interventional treatment trial for Childhood Renal Cell Carcinoma

Eligibility Criteria

undefined - 29 Years (Child, Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria: Newly diagnosed disease of 1 of the following histologic types: Focal anaplastic Wilms' tumor Diffuse anaplastic Wilms' tumor Clear cell sarcoma of the kidney Malignant rhabdoid tumor (renal or extrarenal) Renal cell carcinoma Clear cell Papillary Renal medullary Oncocytoid Sarcomatoid Chromophobe Translocation Collecting duct Carcinoma associated with neuroblastoma Renal cell carcinoma unclassified Specimens/materials must be submitted for central review by Day 7 Patients must begin protocol therapy on AREN0321 by Day 14 after surgery or biopsy (surgery/biopsy is Day 0), unless medically contraindicated Karnofsky performance status (PS) must be >= 50 for patients > 16 years if age and Lansky PS must be >= 50 for patients =< 16 years of age Patients must not have received systemic chemotherapy or radiation therapy prior to treatment on this study UNLESS they were enrolled on the AREN0532 or AREN0533 studies and received prenephrectomy chemotherapy for what was originally presumed to be favorable histology Wilms tumor; additionally, patients with pediatric RCC who previously received chemotherapy for another type of malignancy (not the RCC) or non-malignant condition may enroll on the study Total bilirubin =< 1.5 times upper limit of normal (ULN) for age Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST] or serum glutamic pyruvate transaminase (SGPT) (alanine aminotransferase [ ALT]) < 2.5 times ULN for age Shortening fraction of >= 27% by echocardiogram OR ejection fraction of >= 50% by radionuclide angiogram Female patients of childbearing age must have a negative pregnancy test Female patients who are lactating must agree to stop breast-feeding Sexually active patients of childbearing potential must agree to use effective contraception All patients and/or their parents or legal guardians must sign a written informed consent All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met

Sites / Locations

Children's Hospital of Alabama
University of Alabama at Birmingham
University of South Alabama
Phoenix Childrens Hospital
University of Arizona Health Sciences Center
Arkansas Children's Hospital
Southern California Permanente Medical Group
Loma Linda University Medical Center
Miller Children's Hospital
Children's Hospital Los Angeles
Children's Hospital Central California
Children's Hospital and Research Center at Oakland
Kaiser Permanente-Oakland
Childrens Hospital of Orange County
Lucile Packard Children's Hospital Stanford University
Rady Children's Hospital - San Diego
University of California San Francisco Medical Center-Parnassus
Children's Hospital Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Connecticut Children's Medical Center
Alfred I duPont Hospital for Children
Children's National Medical Center
Lombardi Comprehensive Cancer Center at Georgetown University
Broward Health Medical Center
Golisano Children's Hospital of Southwest Florida
Memorial Healthcare System - Joe DiMaggio Children's Hospital
Nemours Children's Clinic-Jacksonville South
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami Children's Hospital
Baptist Hospital of Miami
Florida Hospital Orlando
UF Cancer Center at Orlando Health
Nemours Children's Clinic - Pensacola
All Children's Hospital
Saint Joseph Children's Hospital of Tampa
Saint Mary's Hospital
Children's Healthcare of Atlanta - Egleston
Memorial University Medical Center
University of Hawaii Cancer Center
Tripler Army Medical Center
Saint Luke's Mountain States Tumor Institute
Lurie Children's Hospital-Chicago
University of Illinois
University of Chicago Comprehensive Cancer Center
Loyola University Medical Center
Advocate Children's Hospital-Oak Lawn
Advocate Lutheran General Hospital.
Saint Jude Midwest Affiliate
Southern Illinois University
Riley Hospital for Children
Saint Vincent Hospital and Health Services
Blank Children's Hospital
University of Iowa Hospitals and Clinics
University of Kentucky/Markey Cancer Center
Kosair Children's Hospital
Tulane University Health Sciences Center
Children's Hospital New Orleans
Eastern Maine Medical Center
Maine Children's Cancer Program
Sinai Hospital of Baltimore
Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center
Walter Reed National Military Medical Center
Massachusetts General Hospital Cancer Center
Dana-Farber Cancer Institute
University of Massachusetts Medical School
C S Mott Children's Hospital
Wayne State University/Karmanos Cancer Institute
Saint John Hospital and Medical Center
Michigan State University Clinical Center
Hurley Medical Center
Helen DeVos Children's Hospital at Spectrum Health
Bronson Methodist Hospital
Kalamazoo Center for Medical Studies
Children's Hospitals and Clinics of Minnesota - Minneapolis
Mayo Clinic
University of Mississippi Medical Center
The Childrens Mercy Hospital
Cardinal Glennon Children's Medical Center
Washington University School of Medicine
Saint John's Mercy Medical Center
Children's Hospital and Medical Center of Omaha
University of Nebraska Medical Center
Nevada Cancer Research Foundation CCOP
Dartmouth Hitchcock Medical Center
Hackensack University Medical Center
Morristown Memorial Hospital
UMDNJ - Robert Wood Johnson University Hospital
Newark Beth Israel Medical Center
Saint Joseph's Regional Medical Center
Overlook Hospital
University of New Mexico Cancer Center
University of New Mexico
Roswell Park Cancer Institute
The Steven and Alexandra Cohen Children's Medical Center of New York
New York University Langone Medical Center
Columbia University Medical Center
Memorial Sloan-Kettering Cancer Center
Weill Medical College of Cornell University
University of Rochester
Stony Brook University Medical Center
State University of New York Upstate Medical University
Mission Hospital-Memorial Campus
University of North Carolina
Carolinas Medical Center
Novant Health Presbyterian Medical Center
Duke University Medical Center
East Carolina University
Wake Forest University Health Sciences
Children's Hospital Medical Center of Akron
Cincinnati Children's Hospital Medical Center
Rainbow Babies and Childrens Hospital
Cleveland Clinic Foundation
Nationwide Children's Hospital
Dayton Children's Hospital
The Toledo Hospital/Toledo Children's Hospital
Mercy Children's Hospital
University of Oklahoma Health Sciences Center
Natalie Warren Bryant Cancer Center at Saint Francis
Legacy Emanuel Children's Hospital
Legacy Emanuel Hospital and Health Center
Lehigh Valley Hospital - Muhlenberg
Geisinger Medical Center
Penn State Hershey Children's Hospital
Children's Hospital of Philadelphia
Saint Christopher's Hospital for Children
Children's Hospital of Pittsburgh of UPMC
Rhode Island Hospital
Palmetto Health Richland
BI-LO Charities Children's Cancer Center
Greenville Cancer Treatment Center
Sanford USD Medical Center - Sioux Falls
T C Thompson Children's Hospital
East Tennessee Childrens Hospital
St. Jude Children's Research Hospital
Vanderbilt-Ingram Cancer Center
Texas Tech University Health Science Center-Amarillo
Dell Children's Medical Center of Central Texas
Driscoll Children's Hospital
Medical City Dallas Hospital
University of Texas Southwestern Medical Center
Cook Children's Medical Center
Baylor College of Medicine
Covenant Children's Hospital
Methodist Children's Hospital of South Texas
University of Texas Health Science Center at San Antonio
Scott and White Memorial Hospital
Primary Children's Hospital
University of Vermont College of Medicine
Inova Fairfax Hospital
Childrens Hospital-King's Daughters
Naval Medical Center - Portsmouth
Virginia Commonwealth University/Massey Cancer Center
Carilion Clinic Children's Hospital
Seattle Children's Hospital
Providence Sacred Heart Medical Center and Children's Hospital
Mary Bridge Children's Hospital and Health Center
Madigan Army Medical Center
West Virginia University Charleston
University of Wisconsin Hospital and Clinics
Marshfield Clinic
Midwest Children's Cancer Center
John Hunter Children's Hospital
Sydney Children's Hospital
The Children's Hospital at Westmead
Royal Brisbane and Women's Hospital
Royal Children's Hospital-Brisbane
Women's and Children's Hospital-Adelaide
Royal Children's Hospital
Princess Margaret Hospital for Children
Alberta Children's Hospital
University of Alberta Hospital
British Columbia Children's Hospital
CancerCare Manitoba
Janeway Child Health Centre
IWK Health Centre
McMaster Children's Hospital at Hamilton Health Sciences
Chedoke-McMaster Hospitals
Cancer Centre of Southeastern Ontario at Kingston General Hospital
Children's Hospital
Children's Hospital of Eastern Ontario
Hospital for Sick Children
The Montreal Children's Hospital of the MUHC
Centre Hospitalier Universitaire Sainte-Justine
Centre Hospitalier Universitaire de Quebec
Saskatoon Cancer Centre
Starship Children's Hospital
San Jorge Children's Hospital

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm 6

Arm Type

Experimental

Arm Label

Surgery

Treatment (UH-1)

Treatment (window/UH-1)

Treatment (UH-2)

Treatment (regimen I)

Treatment (regimen DD-4A)

Arm Description

Patients with completely resectable stage I-IV RCC undergo surgical resection. Patients with incompletely resectable stage III-IV RCC undergo treatment as per physician's choice.

Patients receive combination chemotherapy comprising vincristine, doxorubicin hydrochloride, cyclophosphamide, etoposide, and carboplatin. Patients whose primary tumors were initially resected undergo radiotherapy once daily 5 days a week for 4-5½ weeks beginning on day 1 in week 1. Patients with delayed primary tumor resection undergo radiotherapy beginning on day 1 in week 13. If the primary tumor was not previously resected, patients undergo resection, if feasible, in week 13. Patients with unresectable clear cell sarcoma of the kidney (CCSK) receive no further study therapy.

Patients receive vincristine IV on days 1 and 8 and irinotecan hydrochloride IV over 30 minutes on days 1-5 and 8-12 (course 1). Patients with progressive disease (PD) are treated with regimen UH-1. Patients with stable disease (SD), partial response (PR), or complete response (CR) receive another course of irinotecan hydrochloride/vincristine window therapy beginning on day 22. After the second course, patients with SD or PD are treated with regimen UH-1 and patients with PR or CR are treated with regimen UH-2.

Patients receive combination chemotherapy comprising vincristine, doxorubicin hydrochloride, cyclophosphamide, etoposide, carboplatin, and irinotecan hydrochloride. Patients whose primary tumors were initially resected undergo radiotherapy as in regimen UH-1 beginning on day 1 in week 1. Patients with delayed primary tumor resection undergo radiotherapy as in regimen UH-1 beginning on day 1 in week 7. If the primary tumor was not previously resected, patients undergo resection, if feasible, in week 7.

Patients receive vincristine, doxorubicin hydrochloride, cyclophosphamide, and etoposide. Patients whose primary tumors were initially resected (except those with stage I CCSK) undergo radiotherapy as in regimen UH-1 beginning on day 1 in week 1. Patients with delayed primary tumor resection undergo radiotherapy as in regimen UH-1 beginning on day 1 in week 13. If the primary tumor was not previously resected, patients undergo resection, if feasible, in week 13.

Patients receive dactinomycin, vincristine, and doxorubicin hydrochloride. Patients whose primary tumors were initially resected undergo radiotherapy as in regimen UH-1 beginning on day 1 in week 1. Patients with delayed primary tumor resection undergo radiotherapy as in regimen UH-1 beginning on day 1 in week 13. If the primary tumor was not previously resected, patients undergo resection, if feasible, in week 13.

Outcomes

Primary Outcome Measures

Event-Free Survival of Patients With Diffuse Anaplastic Wilms' Tumor (DAWT)

Compare the outcome of patients treated with alternating CyCE/VDCy chemotherapy (with or without vincristine/irinotecan cycles) to a fixed outcome based on that seen for similar patients treated with NWTS-5 (NCT00002610).

Long-term Survival of Patients With Stage I-IV Malignant Rhabdoid Tumors

The outcome of these patients will be compared with a fixed outcome based on that seen for similar patients treated with NWTS-5 regimen (NCT00002610).

Response Rate

Criteria for response assessed by three-dimensional measurement: Complete Response (CR), Disappearance of all index lesions and non-index lesions. No new lesions; Partial Response (PR), At least a 65% decrease in the sum of the volumes of the index lesions. No new lesions; Response rate (RR) = CR+PR of patients who received window therapy.

Event Free Survival Probability

Event-free survival will be informally compared to that seem for similar patients treated on NWTS-5 (NCT00002610).

Toxicity Rate

Percentage of participants with Grade 4 cardiac toxicities, Grade 4 Sinusoidal Obstruction Syndrome (SOS), and treatment-related deaths determined using CTCAE v4.

Secondary Outcome Measures

Number of Patients With INI1 Mutations in Renal and Extrarenal Malignant Rhabdoid Tumor by Fluorescent in Situ Hybridization

Frequency of TP53 Mutations

Full Information

NCT ID

NCT00335556

First Posted

June 8, 2006

Last Updated

June 22, 2017

Sponsor

Children's Oncology Group

Collaborators

National Cancer Institute (NCI)

1. Study Identification

Unique Protocol Identification Number

NCT00335556

Brief Title

Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors

Official Title

Treatment of High Risk Renal Tumors: A Groupwide Phase II Study

Study Type

Interventional

2. Study Status

Record Verification Date

April 2016

Overall Recruitment Status

Completed

Study Start Date

June 2006 (undefined)

Primary Completion Date

December 2015 (Actual)

Study Completion Date

undefined (undefined)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Children's Oncology Group

Collaborators

National Cancer Institute (NCI)

4. Oversight

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

This phase II trial is studying how well combination chemotherapy, radiation therapy, and/or surgery work in treating patients with high-risk kidney tumors. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving combination chemotherapy together with radiation therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.

Detailed Description

PRIMARY OBJECTIVES: I. Evaluate whether a treatment regimen containing cyclophosphamide, carboplatin, and etoposide alternating with vincristine, doxorubicin hydrochloride, and cyclophosphamide (regimen UH-1) improves the event-free and overall survival of patients with diffuse anaplastic Wilms' tumor (DAWT) as compared to historical controls. II. Evaluate, in a phase II "window" study, the antitumor activity of a combination of vincristine and protracted-schedule irinotecan hydrochloride in patients with metastatic DAWT. III. Evaluate whether regimen UH-1 improves the event-free and overall survival of patients with malignant rhabdoid tumor (MRT) as compared to historical controls. IV. Maintain the excellent event-free survival of patients with stage I clear cell sarcoma of the kidney (CCSK) without the use of abdominal irradiation. SECONDARY OBJECTIVES: I. Describe the outcomes of patients with stage I DAWT or stages I-III focal anaplastic Wilms' tumor (FAWT) treated with vincristine, dactinomycin, doxorubicin hydrochloride, and flank radiation. II. Describe the outcomes of patients with stage IV FAWT or stage IV CCSK treated with regimen UH-1. III. Describe event-free and overall survival of children and adolescents with localized renal cell carcinoma (RCC) (including patients with local lymph node involvement) treated with surgical resection without adjuvant therapy. IV. Describe response rate, event-free survival, and overall survival of patients with unresectable or distantly metastatic RCC treated according to institutional preference. V. Correlate histologic and molecular cytogenetic findings with outcome in pediatric RCC. VI. Evaluate the frequency of germline and inherited INI1 mutations in renal and extrarenal MRT and correlate the presence of detectable INI1 mutation with clinical outcome. VII. Determine the frequency of TP53 mutations in anaplastic Wilms' tumor and correlate the presence of detectable TP53 mutation with clinical outcome. OUTLINE: This is a multicenter study. Patients are assigned to 1 of 6 treatment regimens according to tumor histology, stage of disease, and response to treatment. SURGERY (renal cell carcinoma [RCC]): Patients with completely resectable stage I-IV RCC undergo surgical resection. Patients with incompletely resectable stage III-IV RCC undergo treatment as per physician's choice. REGIMEN UH-1 (stage II-III or stage IV [with no measurable disease] diffuse anaplastic Wilms' tumor [DAWT], stage I-IV malignant rhabdoid tumor [MRT], stage IV focal anaplastic Wilms' tumor [FAWT], or stage IV clear cell sarcoma of the kidney [CCSK]): Patients receive vincristine IV on day 1 in weeks 1-3, 10-12, 13-15, 22-24, and 28-30; doxorubicin hydrochloride IV over 15 minutes on day 1 and cyclophosphamide (CPM2) IV over 15-30 minutes on day 1 in weeks 1, 10, 13, 22, and 28; and cyclophosphamide (at lower doses [CPM1]) IV over 1 hour and etoposide IV over 1 hour on days 1-4 and carboplatin IV over 1 hour on day 1 in weeks 4, 7, 16, 19, and 25. Patients whose primary tumors were initially resected undergo radiotherapy once daily 5 days a week for 4-5½ weeks beginning on day 1 in week 1. Patients with delayed primary tumor resection undergo radiotherapy beginning on day 1 in week 13. If the primary tumor was not previously resected, patients undergo resection, if feasible, in week 13. Patients with unresectable CCSK receive no further study therapy. IRINOTECAN/VINCRISTINE WINDOW THERAPY* (stage IV DAWT with measurable disease at diagnosis): Patients receive vincristine IV on day 1 and irinotecan hydrochloride IV over 30 minutes on days 1-5 in weeks 1 and 2. Patients with progressive disease (PD) are treated with regimen UH-1. Patients with stable disease (SD), partial response (PR), or complete response (CR) receive another course of irinotecan hydrochloride/vincristine window therapy beginning on day 22. After the second course, patients with SD or PD are treated with regimen UH-1 and patients with PR or CR are treated with regimen UH-2. NOTE: *Patients who are eligible for but who are unwilling to receive window therapy, receive therapy on regimen UH-1. REGIMEN UH-2 (DAWT with CR/PR to irinotecan hydrochloride/vincristine window therapy): Patients receive vincristine on day 1 in weeks 1-3, 10, 11, 16-21, 25, 26, 28-30, and 34-36 and doxorubicin hydrochloride and CPM2 as in regimen UH-1 in weeks 1, 16, 19, 28, and 34. Patients also receive CPM1, etoposide, and carboplatin as in regimen UH-1 in weeks 4, 7, 13, 22, and 31 and irinotecan hydrochloride IV over 30 minutes on days 1-5 in weeks 10, 11, 25, and 26. Patients whose primary tumors were initially resected undergo radiotherapy as in regimen UH-1 beginning on day 1 in week 1. Patients with delayed primary tumor resection undergo radiotherapy as in regimen UH-1 beginning on day 1 in week 7. If the primary tumor was not previously resected, patients undergo resection, if feasible, in week 7. REGIMEN I (stage I-III CCSK): Patients receive vincristine IV on day 1 in weeks 1-3, 5-9, 8-9, 11-14, 19, and 25; doxorubicin hydrochloride IV over 15 minutes on day 1 and cyclophosphamide IV over 1 hour on days 1-3 in weeks 1, 7, 13, 19, and 25; and cyclophosphamide IV and etoposide IV on days 1-5 in weeks 4, 10, 16, and 22. Patients whose primary tumors were initially resected (except those with stage I CCSK) undergo radiotherapy as in regimen UH-1 beginning on day 1 in week 1. Patients with delayed primary tumor resection undergo radiotherapy as in regimen UH-1 beginning on day 1 in week 13. If the primary tumor was not previously resected, patients undergo resection, if feasible, in week 13. REGIMEN DD-4A (stage I DAWT or stages I-III FAWT): Patients receive dactinomycin IV over 1-5 minutes on day 1 in weeks 1, 7, 13, 19, and 25; vincristine IV on day 1 in weeks 1-10, 13, 16, 19, 22, and 25; and doxorubicin hydrochloride IV over 15 minutes on day 1 in weeks 4,10, 16, and 22. Patients whose primary tumors were initially resected undergo radiotherapy as in regimen UH-1 beginning on day 1 in week 1. Patients with delayed primary tumor resection undergo radiotherapy as in regimen UH-1 beginning on day 1 in week 13. If the primary tumor was not previously resected, patients undergo resection, if feasible, in week 13. Treatment continues in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed periodically for at least 3 years.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Childhood Renal Cell Carcinoma, Clear Cell Renal Cell Carcinoma, Clear Cell Sarcoma of the Kidney, Papillary Renal Cell Carcinoma, Rhabdoid Tumor of the Kidney, Stage I Renal Cell Cancer, Stage I Renal Wilms Tumor, Stage II Renal Cell Cancer, Stage II Renal Wilms Tumor, Stage III Renal Cell Cancer, Stage III Renal Wilms Tumor, Stage IV Renal Cell Cancer, Stage IV Renal Wilms Tumor

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 2

Interventional Study Model

Parallel Assignment

Masking

None (Open Label)

Allocation

Non-Randomized

Enrollment

291 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Surgery

Arm Type

Experimental

Arm Description

Patients with completely resectable stage I-IV RCC undergo surgical resection. Patients with incompletely resectable stage III-IV RCC undergo treatment as per physician's choice.

Arm Title

Treatment (UH-1)

Arm Type

Experimental

Arm Description

Arm Title

Treatment (window/UH-1)

Arm Type

Experimental

Arm Description

Arm Title

Treatment (UH-2)

Arm Type

Experimental

Arm Description

Arm Title

Treatment (regimen I)

Arm Type

Experimental

Arm Description

Arm Title

Treatment (regimen DD-4A)

Arm Type

Experimental

Arm Description

Intervention Type

Drug

Intervention Name(s)

Doxorubicin Hydrochloride

Intervention Description

Given IV

Intervention Type

Drug

Intervention Name(s)

Irinotecan Hydrochloride

Intervention Description

Given IV

Intervention Type

Procedure

Intervention Name(s)

Conventional Surgery

Other Intervention Name(s)

surgery, conventional

Intervention Description

Patients undergo resection

Intervention Type

Drug

Intervention Name(s)

Cyclophosphamide

Intervention Description

Given IV

Intervention Type

Drug

Intervention Name(s)

Etoposide

Other Intervention Name(s)

Lastet

Intervention Description

Given IV

Intervention Type

Drug

Intervention Name(s)

Carboplatin

Intervention Description

Given IV

Intervention Type

Biological

Intervention Name(s)

Dactinomycin

Other Intervention Name(s)

Lyovac Cosmegen

Intervention Description

Given IV

Intervention Type

Drug

Intervention Name(s)

Vincristine Sulfate

Other Intervention Name(s)

Kyocristine, Oncovin, VCR, Vincasar

Intervention Description

Given IV

Intervention Type

Radiation

Intervention Name(s)

Radiation Therapy

Other Intervention Name(s)

Cancer Radiotherapy, Irradiate, Irradiated, Irradiation, RT

Intervention Description

Undergo radiotherapy

Intervention Type

Other

Intervention Name(s)

Laboratory Biomarker Analysis

Intervention Description

Correlative studies

Primary Outcome Measure Information:

Title

Event-Free Survival of Patients With Diffuse Anaplastic Wilms' Tumor (DAWT)

Description

Time Frame

4 years

Title

Long-term Survival of Patients With Stage I-IV Malignant Rhabdoid Tumors

Description

The outcome of these patients will be compared with a fixed outcome based on that seen for similar patients treated with NWTS-5 regimen (NCT00002610).

Time Frame

4 years

Title

Response Rate

Description

Time Frame

Up to 2 months

Title

Event Free Survival Probability

Description

Event-free survival will be informally compared to that seem for similar patients treated on NWTS-5 (NCT00002610).

Time Frame

4 years

Title

Toxicity Rate

Description

Percentage of participants with Grade 4 cardiac toxicities, Grade 4 Sinusoidal Obstruction Syndrome (SOS), and treatment-related deaths determined using CTCAE v4.

Time Frame

Up to 4 years

Secondary Outcome Measure Information:

Title

Number of Patients With INI1 Mutations in Renal and Extrarenal Malignant Rhabdoid Tumor by Fluorescent in Situ Hybridization

Time Frame

At baseline

Title

Frequency of TP53 Mutations

Time Frame

At baseline

10. Eligibility

Sex

All

Maximum Age & Unit of Time

29 Years

Accepts Healthy Volunteers

Eligibility Criteria

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Jeffrey Dome, MD

Organizational Affiliation

Children's Oncology Group

Official's Role

Principal Investigator

Facility Information:

Facility Name

Children's Hospital of Alabama

City

Birmingham

State/Province

Alabama

ZIP/Postal Code

35233

Country

United States

Facility Name

University of Alabama at Birmingham

City

Birmingham

State/Province

Alabama

ZIP/Postal Code

35233

Country

United States

Facility Name

University of South Alabama

City

Mobile

State/Province

Alabama

ZIP/Postal Code

36604

Country

United States

Facility Name

Phoenix Childrens Hospital

City

Phoenix

State/Province

Arizona

ZIP/Postal Code

85016

Country

United States

Facility Name

University of Arizona Health Sciences Center

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85724

Country

United States

Facility Name

Arkansas Children's Hospital

City

Little Rock

State/Province

Arkansas

ZIP/Postal Code

72202-3591

Country

United States

Facility Name

Southern California Permanente Medical Group

City

Downey

State/Province

California

ZIP/Postal Code

90242

Country

United States

Facility Name

Loma Linda University Medical Center

City

Loma Linda

State/Province

California

ZIP/Postal Code

92354

Country

United States

Facility Name

Miller Children's Hospital

City

Long Beach

State/Province

California

ZIP/Postal Code

90806

Country

United States

Facility Name

Children's Hospital Los Angeles

City

Los Angeles

State/Province

California

ZIP/Postal Code

90027

Country

United States

Facility Name

Children's Hospital Central California

City

Madera

State/Province

California

ZIP/Postal Code

93636-8762

Country

United States

Facility Name

Children's Hospital and Research Center at Oakland

City

Oakland

State/Province

California

ZIP/Postal Code

94609-1809

Country

United States

Facility Name

Kaiser Permanente-Oakland

City

Oakland

State/Province

California

ZIP/Postal Code

94611

Country

United States

Facility Name

Childrens Hospital of Orange County

City

Orange

State/Province

California

ZIP/Postal Code

92868

Country

United States

Facility Name

Lucile Packard Children's Hospital Stanford University

City

Palo Alto

State/Province

California

ZIP/Postal Code

94304

Country

United States

Facility Name

Rady Children's Hospital - San Diego

City

San Diego

State/Province

California

ZIP/Postal Code

92123

Country

United States

Facility Name

University of California San Francisco Medical Center-Parnassus

City

San Francisco

State/Province

California

ZIP/Postal Code

94143

Country

United States

Facility Name

Children's Hospital Colorado

City

Aurora

State/Province

Colorado

ZIP/Postal Code

80045

Country

United States

Facility Name

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

City

Denver

State/Province

Colorado

ZIP/Postal Code

80218

Country

United States

Facility Name

Connecticut Children's Medical Center

City

Hartford

State/Province

Connecticut

ZIP/Postal Code

06106

Country

United States

Facility Name

Alfred I duPont Hospital for Children

City

Wilmington

State/Province

Delaware

ZIP/Postal Code

19803

Country

United States

Facility Name

Children's National Medical Center

City

Washington, D.C.

State/Province

District of Columbia

ZIP/Postal Code

20010

Country

United States

Facility Name

Lombardi Comprehensive Cancer Center at Georgetown University

City

Washington, D.C.

State/Province

District of Columbia

ZIP/Postal Code

20057

Country

United States

Facility Name

Broward Health Medical Center

City

Fort Lauderdale

State/Province

Florida

ZIP/Postal Code

33316

Country

United States

Facility Name

Golisano Children's Hospital of Southwest Florida

City

Fort Myers

State/Province

Florida

ZIP/Postal Code

33908

Country

United States

Facility Name

Memorial Healthcare System - Joe DiMaggio Children's Hospital

City

Hollywood

State/Province

Florida

ZIP/Postal Code

33021

Country

United States

Facility Name

Nemours Children's Clinic-Jacksonville South

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32207

Country

United States

Facility Name

University of Miami Miller School of Medicine-Sylvester Cancer Center

City

Miami

State/Province

Florida

ZIP/Postal Code

33136

Country

United States

Facility Name

Miami Children's Hospital

City

Miami

State/Province

Florida

ZIP/Postal Code

33155

Country

United States

Facility Name

Baptist Hospital of Miami

City

Miami

State/Province

Florida

ZIP/Postal Code

33176

Country

United States

Facility Name

Florida Hospital Orlando

City

Orlando

State/Province

Florida

ZIP/Postal Code

32803

Country

United States

Facility Name

UF Cancer Center at Orlando Health

City

Orlando

State/Province

Florida

ZIP/Postal Code

32806

Country

United States

Facility Name

Nemours Children's Clinic - Pensacola

City

Pensacola

State/Province

Florida

ZIP/Postal Code

32504

Country

United States

Facility Name

All Children's Hospital

City

Saint Petersburg

State/Province

Florida

ZIP/Postal Code

33701

Country

United States

Facility Name

Saint Joseph Children's Hospital of Tampa

City

Tampa

State/Province

Florida

ZIP/Postal Code

33607

Country

United States

Facility Name

Saint Mary's Hospital

City

West Palm Beach

State/Province

Florida

ZIP/Postal Code

33407

Country

United States

Facility Name

Children's Healthcare of Atlanta - Egleston

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30322

Country

United States

Facility Name

Memorial University Medical Center

City

Savannah

State/Province

Georgia

ZIP/Postal Code

31404

Country

United States

Facility Name

University of Hawaii Cancer Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Tripler Army Medical Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96859

Country

United States

Facility Name

Saint Luke's Mountain States Tumor Institute

City

Boise

State/Province

Idaho

ZIP/Postal Code

83712

Country

United States

Facility Name

Lurie Children's Hospital-Chicago

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60611

Country

United States

Facility Name

University of Illinois

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60612

Country

United States

Facility Name

University of Chicago Comprehensive Cancer Center

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60637

Country

United States

Facility Name

Loyola University Medical Center

City

Maywood

State/Province

Illinois

ZIP/Postal Code

60153

Country

United States

Facility Name

Advocate Children's Hospital-Oak Lawn

City

Oak Lawn

State/Province

Illinois

ZIP/Postal Code

60453

Country

United States

Facility Name

Advocate Lutheran General Hospital.

City

Park Ridge

State/Province

Illinois

ZIP/Postal Code

60068

Country

United States

Facility Name

Saint Jude Midwest Affiliate

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61602

Country

United States

Facility Name

Southern Illinois University

City

Springfield

State/Province

Illinois

ZIP/Postal Code

62702

Country

United States

Facility Name

Riley Hospital for Children

City

Indianapolis

State/Province

Indiana

ZIP/Postal Code

46202

Country

United States

Facility Name

Saint Vincent Hospital and Health Services

City

Indianapolis

State/Province

Indiana

ZIP/Postal Code

46260

Country

United States

Facility Name

Blank Children's Hospital

City

Des Moines

State/Province

Iowa

ZIP/Postal Code

50309

Country

United States

Facility Name

University of Iowa Hospitals and Clinics

City

Iowa City

State/Province

Iowa

ZIP/Postal Code

52242

Country

United States

Facility Name

University of Kentucky/Markey Cancer Center

City

Lexington

State/Province

Kentucky

ZIP/Postal Code

40536

Country

United States

Facility Name

Kosair Children's Hospital

City

Louisville

State/Province

Kentucky

ZIP/Postal Code

40202

Country

United States

Facility Name

Tulane University Health Sciences Center

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70112

Country

United States

Facility Name

Children's Hospital New Orleans

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70118

Country

United States

Facility Name

Eastern Maine Medical Center

City

Bangor

State/Province

Maine

ZIP/Postal Code

04401

Country

United States

Facility Name

Maine Children's Cancer Program

City

Scarborough

State/Province

Maine

ZIP/Postal Code

04074

Country

United States

Facility Name

Sinai Hospital of Baltimore

City

Baltimore

State/Province

Maryland

ZIP/Postal Code

21215

Country

United States

Facility Name

Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center

City

Baltimore

State/Province

Maryland

ZIP/Postal Code

21287

Country

United States

Facility Name

Walter Reed National Military Medical Center

City

Bethesda

State/Province

Maryland

ZIP/Postal Code

20889-5600

Country

United States

Facility Name

Massachusetts General Hospital Cancer Center

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02114

Country

United States

Facility Name

Dana-Farber Cancer Institute

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02115

Country

United States

Facility Name

University of Massachusetts Medical School

City

Worcester

State/Province

Massachusetts

ZIP/Postal Code

01655

Country

United States

Facility Name

C S Mott Children's Hospital

City

Ann Arbor

State/Province

Michigan

ZIP/Postal Code

48109

Country

United States

Facility Name

Wayne State University/Karmanos Cancer Institute

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48201

Country

United States

Facility Name

Saint John Hospital and Medical Center

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48236

Country

United States

Facility Name

Michigan State University Clinical Center

City

East Lansing

State/Province

Michigan

ZIP/Postal Code

48824-7016

Country

United States

Facility Name

Hurley Medical Center

City

Flint

State/Province

Michigan

ZIP/Postal Code

48502

Country

United States

Facility Name

Helen DeVos Children's Hospital at Spectrum Health

City

Grand Rapids

State/Province

Michigan

ZIP/Postal Code

49503

Country

United States

Facility Name

Bronson Methodist Hospital

City

Kalamazoo

State/Province

Michigan

ZIP/Postal Code

49007

Country

United States

Facility Name

Kalamazoo Center for Medical Studies

City

Kalamazoo

State/Province

Michigan

ZIP/Postal Code

49008

Country

United States

Facility Name

Children's Hospitals and Clinics of Minnesota - Minneapolis

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55404

Country

United States

Facility Name

Mayo Clinic

City

Rochester

State/Province

Minnesota

ZIP/Postal Code

55905

Country

United States

Facility Name

University of Mississippi Medical Center

City

Jackson

State/Province

Mississippi

ZIP/Postal Code

39216

Country

United States

Facility Name

The Childrens Mercy Hospital

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64108

Country

United States

Facility Name

Cardinal Glennon Children's Medical Center

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63104

Country

United States

Facility Name

Washington University School of Medicine

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63110

Country

United States

Facility Name

Saint John's Mercy Medical Center

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63141

Country

United States

Facility Name

Children's Hospital and Medical Center of Omaha

City

Omaha

State/Province

Nebraska

ZIP/Postal Code

68114

Country

United States

Facility Name

University of Nebraska Medical Center

City

Omaha

State/Province

Nebraska

ZIP/Postal Code

68198

Country

United States

Facility Name

Nevada Cancer Research Foundation CCOP

City

Las Vegas

State/Province

Nevada

ZIP/Postal Code

89106

Country

United States

Facility Name

Dartmouth Hitchcock Medical Center

City

Lebanon

State/Province

New Hampshire

ZIP/Postal Code

03756

Country

United States

Facility Name

Hackensack University Medical Center

City

Hackensack

State/Province

New Jersey

ZIP/Postal Code

07601

Country

United States

Facility Name

Morristown Memorial Hospital

City

Morristown

State/Province

New Jersey

ZIP/Postal Code

07962

Country

United States

Facility Name

UMDNJ - Robert Wood Johnson University Hospital

City

New Brunswick

State/Province

New Jersey

ZIP/Postal Code

08903

Country

United States

Facility Name

Newark Beth Israel Medical Center

City

Newark

State/Province

New Jersey

ZIP/Postal Code

07112

Country

United States

Facility Name

Saint Joseph's Regional Medical Center

City

Paterson

State/Province

New Jersey

ZIP/Postal Code

07503

Country

United States

Facility Name

Overlook Hospital

City

Summit

State/Province

New Jersey

ZIP/Postal Code

07902

Country

United States

Facility Name

University of New Mexico Cancer Center

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87106

Country

United States

Facility Name

University of New Mexico

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87106

Country

United States

Facility Name

Roswell Park Cancer Institute

City

Buffalo

State/Province

New York

ZIP/Postal Code

14263

Country

United States

Facility Name

The Steven and Alexandra Cohen Children's Medical Center of New York

City

New Hyde Park

State/Province

New York

ZIP/Postal Code

11040

Country

United States

Facility Name

New York University Langone Medical Center

City

New York

State/Province

New York

ZIP/Postal Code

10016

Country

United States

Facility Name

Columbia University Medical Center

City

New York

State/Province

New York

ZIP/Postal Code

10032

Country

United States

Facility Name

Memorial Sloan-Kettering Cancer Center

City

New York

State/Province

New York

ZIP/Postal Code

10065

Country

United States

Facility Name

Weill Medical College of Cornell University

City

New York

State/Province

New York

ZIP/Postal Code

10065

Country

United States

Facility Name

University of Rochester

City

Rochester

State/Province

New York

ZIP/Postal Code

14642

Country

United States

Facility Name

Stony Brook University Medical Center

City

Stony Brook

State/Province

New York

ZIP/Postal Code

11794

Country

United States

Facility Name

State University of New York Upstate Medical University

City

Syracuse

State/Province

New York

ZIP/Postal Code

13210

Country

United States

Facility Name

Mission Hospital-Memorial Campus

City

Asheville

State/Province

North Carolina

ZIP/Postal Code

28801

Country

United States

Facility Name

University of North Carolina

City

Chapel Hill

State/Province

North Carolina

ZIP/Postal Code

27599

Country

United States

Facility Name

Carolinas Medical Center

City

Charlotte

State/Province

North Carolina

ZIP/Postal Code

28203

Country

United States

Facility Name

Novant Health Presbyterian Medical Center

City

Charlotte

State/Province

North Carolina

ZIP/Postal Code

28204

Country

United States

Facility Name

Duke University Medical Center

City

Durham

State/Province

North Carolina

ZIP/Postal Code

27710

Country

United States

Facility Name

East Carolina University

City

Greenville

State/Province

North Carolina

ZIP/Postal Code

27858

Country

United States

Facility Name

Wake Forest University Health Sciences

City

Winston-Salem

State/Province

North Carolina

ZIP/Postal Code

27157

Country

United States

Facility Name

Children's Hospital Medical Center of Akron

City

Akron

State/Province

Ohio

ZIP/Postal Code

44308

Country

United States

Facility Name

Cincinnati Children's Hospital Medical Center

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45229

Country

United States

Facility Name

Rainbow Babies and Childrens Hospital

City

Cleveland

State/Province

Ohio

ZIP/Postal Code

44106

Country

United States

Facility Name

Cleveland Clinic Foundation

City

Cleveland

State/Province

Ohio

ZIP/Postal Code

44195

Country

United States

Facility Name

Nationwide Children's Hospital

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43205

Country

United States

Facility Name

Dayton Children's Hospital

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45404

Country

United States

Facility Name

The Toledo Hospital/Toledo Children's Hospital

City

Toledo

State/Province

Ohio

ZIP/Postal Code

43606

Country

United States

Facility Name

Mercy Children's Hospital

City

Toledo

State/Province

Ohio

ZIP/Postal Code

43608

Country

United States

Facility Name

University of Oklahoma Health Sciences Center

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73104

Country

United States

Facility Name

Natalie Warren Bryant Cancer Center at Saint Francis

City

Tulsa

State/Province

Oklahoma

ZIP/Postal Code

74136

Country

United States

Facility Name

Legacy Emanuel Children's Hospital

City

Portland

State/Province

Oregon

ZIP/Postal Code

97227

Country

United States

Facility Name

Legacy Emanuel Hospital and Health Center

City

Portland

State/Province

Oregon

ZIP/Postal Code

97227

Country

United States

Facility Name

Lehigh Valley Hospital - Muhlenberg

City

Bethlehem

State/Province

Pennsylvania

ZIP/Postal Code

18017

Country

United States

Facility Name

Geisinger Medical Center

City

Danville

State/Province

Pennsylvania

ZIP/Postal Code

17822

Country

United States

Facility Name

Penn State Hershey Children's Hospital

City

Hershey

State/Province

Pennsylvania

ZIP/Postal Code

17033

Country

United States

Facility Name

Children's Hospital of Philadelphia

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19104

Country

United States

Facility Name

Saint Christopher's Hospital for Children

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19134

Country

United States

Facility Name

Children's Hospital of Pittsburgh of UPMC

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15224

Country

United States

Facility Name

Rhode Island Hospital

City

Providence

State/Province

Rhode Island

ZIP/Postal Code

02903

Country

United States

Facility Name

Palmetto Health Richland

City

Columbia

State/Province

South Carolina

ZIP/Postal Code

29203

Country

United States

Facility Name

BI-LO Charities Children's Cancer Center

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29605

Country

United States

Facility Name

Greenville Cancer Treatment Center

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29605

Country

United States

Facility Name

Sanford USD Medical Center - Sioux Falls

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57117-5134

Country

United States

Facility Name

T C Thompson Children's Hospital

City

Chattanooga

State/Province

Tennessee

ZIP/Postal Code

37403

Country

United States

Facility Name

East Tennessee Childrens Hospital

City

Knoxville

State/Province

Tennessee

ZIP/Postal Code

37916

Country

United States

Facility Name

St. Jude Children's Research Hospital

City

Memphis

State/Province

Tennessee

ZIP/Postal Code

38105

Country

United States

Facility Name

Vanderbilt-Ingram Cancer Center

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37232

Country

United States

Facility Name

Texas Tech University Health Science Center-Amarillo

City

Amarillo

State/Province

Texas

ZIP/Postal Code

79106

Country

United States

Facility Name

Dell Children's Medical Center of Central Texas

City

Austin

State/Province

Texas

ZIP/Postal Code

78723

Country

United States

Facility Name

Driscoll Children's Hospital

City

Corpus Christi

State/Province

Texas

ZIP/Postal Code

78411

Country

United States

Facility Name

Medical City Dallas Hospital

City

Dallas

State/Province

Texas

ZIP/Postal Code

75230

Country

United States

Facility Name

University of Texas Southwestern Medical Center

City

Dallas

State/Province

Texas

ZIP/Postal Code

75390

Country

United States

Facility Name

Cook Children's Medical Center

City

Fort Worth

State/Province

Texas

ZIP/Postal Code

76104

Country

United States

Facility Name

Baylor College of Medicine

City

Houston

State/Province

Texas

ZIP/Postal Code

77030

Country

United States

Facility Name

Covenant Children's Hospital

City

Lubbock

State/Province

Texas

ZIP/Postal Code

79410

Country

United States

Facility Name

Methodist Children's Hospital of South Texas

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78229

Country

United States

Facility Name

University of Texas Health Science Center at San Antonio

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78229

Country

United States

Facility Name

Scott and White Memorial Hospital

City

Temple

State/Province

Texas

ZIP/Postal Code

76508

Country

United States

Facility Name

Primary Children's Hospital

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84113

Country

United States

Facility Name

University of Vermont College of Medicine

City

Burlington

State/Province

Vermont

ZIP/Postal Code

05405

Country

United States

Facility Name

Inova Fairfax Hospital

City

Falls Church

State/Province

Virginia

ZIP/Postal Code

22042

Country

United States

Facility Name

Childrens Hospital-King's Daughters

City

Norfolk

State/Province

Virginia

ZIP/Postal Code

23507

Country

United States

Facility Name

Naval Medical Center - Portsmouth

City

Portsmouth

State/Province

Virginia

ZIP/Postal Code

23708-2197

Country

United States

Facility Name

Virginia Commonwealth University/Massey Cancer Center

City

Richmond

State/Province

Virginia

ZIP/Postal Code

23298

Country

United States

Facility Name

Carilion Clinic Children's Hospital

City

Roanoke

State/Province

Virginia

ZIP/Postal Code

24014

Country

United States

Facility Name

Seattle Children's Hospital

City

Seattle

State/Province

Washington

ZIP/Postal Code

98105

Country

United States

Facility Name

Providence Sacred Heart Medical Center and Children's Hospital

City

Spokane

State/Province

Washington

ZIP/Postal Code

99204

Country

United States

Facility Name

Mary Bridge Children's Hospital and Health Center

City

Tacoma

State/Province

Washington

ZIP/Postal Code

98405

Country

United States

Facility Name

Madigan Army Medical Center

City

Tacoma

State/Province

Washington

ZIP/Postal Code

98431

Country

United States

Facility Name

West Virginia University Charleston

City

Charleston

State/Province

West Virginia

ZIP/Postal Code

25304

Country

United States

Facility Name

University of Wisconsin Hospital and Clinics

City

Madison

State/Province

Wisconsin

ZIP/Postal Code

53792

Country

United States

Facility Name

Marshfield Clinic

City

Marshfield

State/Province

Wisconsin

ZIP/Postal Code

54449

Country

United States

Facility Name

Midwest Children's Cancer Center

City

Milwaukee

State/Province

Wisconsin

ZIP/Postal Code

53226

Country

United States

Facility Name

John Hunter Children's Hospital

City

Hunter Regional Mail Centre

State/Province

New South Wales

ZIP/Postal Code

2310

Country

Australia

Facility Name

Sydney Children's Hospital

City

Randwick

State/Province

New South Wales

ZIP/Postal Code

2031

Country

Australia

Facility Name

The Children's Hospital at Westmead

City

Westmead

State/Province

New South Wales

ZIP/Postal Code

2145

Country

Australia

Facility Name

Royal Brisbane and Women's Hospital

City

Herston

State/Province

Queensland

ZIP/Postal Code

4029

Country

Australia

Facility Name

Royal Children's Hospital-Brisbane

City

Herston

State/Province

Queensland

ZIP/Postal Code

4029

Country

Australia

Facility Name

Women's and Children's Hospital-Adelaide

City

North Adelaide

State/Province

South Australia

ZIP/Postal Code

5006

Country

Australia

Facility Name

Royal Children's Hospital

City

Parkville

State/Province

Victoria

ZIP/Postal Code

3052

Country

Australia

Facility Name

Princess Margaret Hospital for Children

City

Perth

State/Province

Western Australia

ZIP/Postal Code

6008

Country

Australia

Facility Name

Alberta Children's Hospital

City

Calgary

State/Province

Alberta

ZIP/Postal Code

T3B 6A8

Country

Canada

Facility Name

University of Alberta Hospital

City

Edmonton

State/Province

Alberta

ZIP/Postal Code

T6G 2B7

Country

Canada

Facility Name

British Columbia Children's Hospital

City

Vancouver

State/Province

British Columbia

ZIP/Postal Code

V6H 3V4

Country

Canada

Facility Name

CancerCare Manitoba

City

Winnipeg

State/Province

Manitoba

ZIP/Postal Code

R3E 0V9

Country

Canada

Facility Name

Janeway Child Health Centre

City

Saint John's

State/Province

Newfoundland and Labrador

ZIP/Postal Code

A1B 3V6

Country

Canada

Facility Name

IWK Health Centre

City

Halifax

State/Province

Nova Scotia

ZIP/Postal Code

B3J 3G9

Country

Canada

Facility Name

McMaster Children's Hospital at Hamilton Health Sciences

City

Hamilton

State/Province

Ontario

ZIP/Postal Code

L8N 3Z5

Country

Canada

Facility Name

Chedoke-McMaster Hospitals

City

Hamilton

State/Province

Ontario

ZIP/Postal Code

L8S 4L8

Country

Canada

Facility Name

Cancer Centre of Southeastern Ontario at Kingston General Hospital

City

Kingston

State/Province

Ontario

ZIP/Postal Code

K7L 5P9

Country

Canada

Facility Name

Children's Hospital

City

London

State/Province

Ontario

ZIP/Postal Code

N6A 5W9

Country

Canada

Facility Name

Children's Hospital of Eastern Ontario

City

Ottawa

State/Province

Ontario

ZIP/Postal Code

K1H 8L1

Country

Canada

Facility Name

Hospital for Sick Children

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M5G 1X8

Country

Canada

Facility Name

The Montreal Children's Hospital of the MUHC

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H3H 1P3

Country

Canada

Facility Name

Centre Hospitalier Universitaire Sainte-Justine

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H3T 1C5

Country

Canada

Facility Name

Centre Hospitalier Universitaire de Quebec

City

Ste-Foy

State/Province

Quebec

ZIP/Postal Code

G1V 4G2

Country

Canada

Facility Name

Saskatoon Cancer Centre

City

Saskatoon

State/Province

Saskatchewan

ZIP/Postal Code

S7N 4H4

Country

Canada

Facility Name

Starship Children's Hospital

City

Grafton

State/Province

Auckland

ZIP/Postal Code

1145

Country

New Zealand

Facility Name

San Jorge Children's Hospital

City

San Juan

ZIP/Postal Code

00912

Country

Puerto Rico

12. IPD Sharing Statement

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Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors

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