Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors
Brain and Central Nervous System Tumors, Neuroblastoma
About this trial
This is an interventional treatment trial for Brain and Central Nervous System Tumors focused on measuring untreated childhood brain stem glioma, childhood high-grade cerebral astrocytoma, childhood low-grade cerebral astrocytoma, untreated childhood cerebellar astrocytoma, childhood choroid plexus tumor, childhood infratentorial ependymoma, childhood supratentorial ependymoma, newly diagnosed childhood ependymoma, untreated childhood medulloblastoma, childhood oligodendroglioma, untreated childhood supratentorial primitive neuroectodermal tumor, disseminated neuroblastoma, localized resectable neuroblastoma, localized unresectable neuroblastoma, regional neuroblastoma, stage 4S neuroblastoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Diagnosis of 1 of the following: Brain stem tumor (histological confirmation not required) Histologically confirmed primary intracranial brain tumor of 1 of the following histologies: Anaplastic (malignant) astrocytoma Glioblastoma Anaplastic (malignant) oligodendroglioma Ependymoma Anaplastic (malignant) ependymoma Anaplastic (malignant) oligoastrocytoma Choroid plexus carcinoma Astroblastoma Polar spongioblastoma Gliomatosis cerebri Anaplastic (malignant) ganglioglioma Pineoblastoma Mixed pineocytoma or pineoblastoma Medulloepithelioma Neuroblastoma Ependymoblastoma Primitive neuroectodermal tumors (PNETs), including medulloblastoma or cerebral or spinal PNETs Has undergone surgery or biopsy of the tumor within the past 2-4 weeks PATIENT CHARACTERISTICS: No concurrent unrelated disease, including hematological or renal disease, that would preclude study treatment PRIOR CONCURRENT THERAPY: No prior chemotherapy or radiotherapy Prior steroids allowed No concurrent steroids as anti-emetics Concurrent steroids allowed for control of tumor-related symptoms
Sites / Locations
- Our Lady's Hospital for Sick Children
- Birmingham Children's Hospital
- Institute of Child Health at University of Bristol
- Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust
- Leeds Cancer Centre at St. James's University Hospital
- Leicester Royal Infirmary
- Royal Liverpool Children's Hospital, Alder Hey
- Royal London Hospital
- Great Ormond Street Hospital for Children NHS Trust
- Central Manchester and Manchester Children's University Hospitals NHS Trust
- Sir James Spence Institute of Child Health
- Queen's Medical Centre
- Oxford Radcliffe Hospital
- Children's Hospital - Sheffield
- Southampton General Hospital
- Royal Marsden NHS Foundation Trust - Surrey
- Royal Belfast Hospital for Sick Children
- Royal Aberdeen Children's Hospital
- Royal Hospital for Sick Children
- Royal Hospital for Sick Children
- Childrens Hospital for Wales