Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma
Lymphoma
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring stage I adult Hodgkin lymphoma, stage II adult Hodgkin lymphoma, adult lymphocyte predominant Hodgkin lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Randomized groups: Histologically proven previously untreated stage I or II supradiaphragmatic Hodgkin's lymphoma No prior staging laparotomy Favorable (closed to accrual as of 4/28/04) or unfavorable (closed to accrual as of 9/2002) prognosis Nonrandomized group: Histologically proven lymphocyte-predominant Hodgkin's lymphoma, nodular subtype (nodular paragranuloma) Stage I with complete or incomplete resection OR Stage II PATIENT CHARACTERISTICS: Age: 15 to 70 Performance status: WHO 0-2 Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified Cardiovascular: No severe cardiac disease that would interfere with normal life expectancy or study treatment Pulmonary: No severe pulmonary disease that would interfere with normal life expectancy or study treatment Other: No other prior or concurrent malignancy except basal cell skin cancer or carcinoma in situ of the cervix No severe neurologic or metabolic disease that would interfere with normal life expectancy or study treatment No psychologic, familial, socioeconomic, or geographic circumstances that would preclude proper staging or compliance HIV negative Not pregnant Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy No prior biologic therapy for this malignancy Chemotherapy No prior chemotherapy for this malignancy Endocrine therapy No prior endocrine therapy for this malignancy Radiotherapy No prior radiotherapy for this malignancy Surgery No prior surgery for this malignancy
Sites / Locations
- Sint Augustinus Ziekenhuis
- A.Z. St. Jan
- C.H.U. Saint-Pierre
- Institut Jules Bordet
- Cliniques Universitaires Saint-Luc
- Centre Hospitalier Universitaire Brugmann
- Universitair Ziekenhuis Antwerpen
- U.Z. Gasthuisberg
- Clinique Universitaire De Mont-Godinne
- Clinique Saint-Pierre
- Centre Hospitalier Annemasse Bonneville
- Centre Hospitalier d'Annecy
- Centre Hospital General Robert Ballanger
- Hopital Duffaut
- Centre Hospitalier de la Cote Basque
- CHR de Besancon - Hopital Jean Minjoz
- Hopital de Beziers
- Hopital Saint Andre
- Institut Bergonie
- C.H. Bourg En Bresse
- CMC Bligny
- CHU de Caen
- Centre Regional Francois Baclesse
- Centre Hospitalier Regional de Chambery
- Hopital Fontenoy
- Centre d'Oncologie et de Radiotherapie de Chaumont le Bois
- Hopital d'Instruction des Armees Percy
- Hopital Antoine Beclere
- Hopital Beaujon
- Hopital Louis Pasteur
- Centre Hospitalier Compiegne
- Centre Hospitalier Sud Francilien - Site Corbeil
- Centre Hospitalier Universitaire Henri Mondor
- Hopital Du Bocage
- Centre de Lutte Contre le Cancer, Georges-Francois Leclerc
- Institut Prive de Cancerologie
- Centre Hospitalier
- Hopital Andre Mignot
- C.H.G. Du Havre - Hopital J. Monod
- Centre Hospitalier Universitaire de Bicetre
- Clinique Victor Hugo
- Centre Hospitalier Lens
- Centre Hospital Universitaire Hop Huriez
- Centre Hospitalier Regional et Universitaire de Lille
- Centre Hospital Regional Universitaire de Limoges
- Centre Hospitalier General
- Clinique Saint Jean
- Centre Leon Berard
- Hopital Edouard Herriot
- Institut J. Paoli and I. Calmettes
- Centre Hospitalier de Meaux
- Hopital Notre-Dame de Bon Secours
- Intercommunal Hospital
- Clinique Gui de Chauliac
- Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle
- Centre Hospitalier de Mulhouse
- Hopital Pasteur
- Centre Antoine Lacassagne
- C.H.U. de Nimes - Groupe Hospitals-Universitaire Caremeau
- Hopital Saint Antoine
- Hopital de la Croix Rouge Francaise des Peupliers
- Hotel Dieu de Paris
- Institut Curie - Section Medicale
- Hopital Lariboisiere
- Hopital Saint-Louis
- CHU Pitie-Salpetriere
- Hopital Cochin
- Hopital Necker
- C.H.G. De Pau
- Hopital Haut Leveque
- Centre Hospitalier Lyon Sud
- Centre Hospitalier Intercommunal de Poissy
- Hopital Rene Dubos
- Polyclinique De Courlancy
- CHG Roanne
- Centre Henri Becquerel
- Centre Rene Huguenin
- C.H.U. Saint Etienne Hospital Nord
- Hopital de Saint Germain-en-Laye
- Centre Medico-Chirurgical Foch
- Centre Hospitalier Regional de Purpan
- Centre Hospitalier Valence
- Centre Hospitalier de Valenciennes
- Centre Alexis Vautrin
- CHU de Nancy - Hopitaux de Brabois
- Hopital Paul Brousse
- Institut Gustave Roussy
- Centro di Riferimento Oncologico - Aviano
- Ospedale Sta. Maria Delle Croci
- Ospedale S. Giovanni A.S. Dipartimente di Oncologia di Turin
- Leyenburg Ziekenhuis
- Groot Ziekengasthuis 's-Hertogenbosch
- Medisch Centrum Alkmaar
- Meander Medisch Centrum
- Comprehensive Cancer Center Amsterdam
- Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
- Onze Lieve Vrouwe Gasthuis
- Academisch Medisch Centrum
- Streekziekenhuizen Gooi-Noord
- Amphia Ziekenhuis - locatie Molengracht
- Atrium Medisch Centrum - Brunssum
- Reinier de Graaf Group
- Catharina Ziekenhuis
- Medisch Spectrum Twente
- Academisch Ziekenhuis Groningen
- Atrium Medical Centre
- Radiotherapeutisch Instituut
- Diaconessenhuis Leiden
- Academisch Ziekenhuis Maastricht
- Sint Antonius Ziekenhuis
- University Medical Center Nijmegen
- Daniel Den Hoed Cancer Center at Erasmus Medical Center
- Maasland Hospital
- Academisch Ziekenhuis Utrecht
- Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
- Instituto Portugues de Oncologia Centro do Porto, SA
- National Cancer Institute - Bratislava
- Institute of Oncology, Ljubljana
- Hospital Universitario 12 de Octubre
- Hopital Cantonal Universitaire de Geneve
- Centre Hospitalier Universitaire Vaudois