Combination Chemotherapy With or Without Rituximab in Treating Patients With Relapsed Non-Hodgkin's Lymphoma
Lymphoma
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring stage III grade 1 follicular lymphoma, stage III grade 2 follicular lymphoma, stage III grade 3 follicular lymphoma, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage IV grade 3 follicular lymphoma, recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically or cytologically proven stage III or IV follicular non-Hodgkin's lymphoma (NHL) Relapsed after or no response (no change/progressive disease) to no more than 2 adequate non-anthracycline-containing systemic chemotherapy regimens At least 2 months of single-agent therapy (e.g., chlorambucil) AND/OR At least 2 consecutive courses of polychemotherapy (e.g., cyclophosphamide, vincristine, and prednisone) or purine analogues Complete or partial remission or no change for at least 4 weeks after completion of prior therapy OR progression during one of a maximum of 2 prior therapy regimens CD20 positive At least 1 bidimensionally measurable mass No greater than 10,000,000/mL circulating tumor cells IgG levels at least 3 g/L No low-grade NHL transformed into intermediate- or high-grade NHL No symptomatic CNS lymphoma No bone marrow involvement only NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology. PATIENT CHARACTERISTICS: Age: 18 and over Performance status: WHO 0-2 Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Bilirubin less than 2.5 times upper limit of normal (ULN) Alkaline phosphatase less than 2.5 times ULN Renal: Creatinine less than 2.5 times ULN BUN less than 2.5 times ULN Cardiovascular: No severe cardiac disease (i.e., severe heart failure requiring symptomatic treatment) Pulmonary: No severe pulmonary disease Other: No severe neurologic or psychiatric disease No severe metabolic disease Not pregnant Fertile patients must use effective contraception No prior malignancy within the past 5 years except nonmelanomatous skin cancer, carcinoma in situ of the cervix, or other cancer curatively treated with surgical therapy HIV negative No uncontrolled asthma or allergy requiring steroids No known hypersensitivity or prior anaphylactic reaction to murine proteins or any component of study drug PRIOR CONCURRENT THERAPY: Biologic therapy: No prior rituximab No prior allogeneic or autologous peripheral blood stem cell transplantation Concurrent filgrastim (G-CSF) for stem cell mobilization allowed Chemotherapy: See Disease Characteristics No prior anthracyclines or mitoxantrone No concurrent chemotherapy for stem cell mobilization Endocrine therapy: Not specified Radiotherapy: Not specified Surgery: Not specified
Sites / Locations
- Canberra Hospital
- Concord Repatriation General Hospital
- Cancer Therapy Centre at Liverpool Hospital
- Institute of Oncology at Prince of Wales Hospital
- Prince of Wales Private Hospital
- Royal North Shore Hospital
- St. Vincent's Hospital
- Sydney Cancer Centre at Royal Prince Alfred Hospital
- St. George Hospital and Community Health Service
- Westmead Breast Centre at NSW Breast Cancer Institute
- Westmead Hospital
- Wollongong Hospital
- Wesley Medical Centre
- Royal Brisbane and Women's Hospital
- Princess Alexandra Hospital
- Greenslopes Private Hospital
- Townsville General Hospital
- Royal Adelaide Hospital Cancer Centre
- Ashford Cancer Centre
- Flinder Medical Centres
- Queen Elizabeth Hospital
- Royal Hobart Hospital
- St. John of God Hospital
- Box Hill Hospital
- John Fawkner Hospital
- Peter MacCallum Cancer Centre
- St. Vincent's Hospital
- Frankston Hospital
- Geelong Hospital
- Austin Hospital
- Alfred Hospital
- Garden Consulting Rooms
- Royal Melbourne Hospital
- Fremantle Hospital
- Mount Medical Centre
- Royal Perth Hospital
- Sir Charles Gairdner Hospital - Perth
- Ziekenhuis Netwerk Antwerpen Middelheim
- Institut Jules Bordet
- Universitair Ziekenhuis Antwerpen
- Algemeen Ziekenhuis Sint Lucas
- U.Z. Gasthuisberg
- H. Hartziekenhuis - Roeselaere.
- Algemeen Ziekenhuis Sint-Augustinus
- Tom Baker Cancer Centre - Calgary
- Cross Cancer Institute at University of Alberta
- British Columbia Cancer Agency - Centre for the Southern Interior
- Nanaimo Cancer Clinic at Nanaimo Regional General Hospital
- Lions Gate Hospital
- Fraser Valley Cancer Centre at British Columbia Cancer Agency
- British Columbia Cancer Agency - Vancouver Cancer Centre
- CancerCare Manitoba
- Moncton Hospital
- Newfoundland Cancer Treatment and Research Foundation
- Nova Scotia Cancer Centre at Queen Elizabeth II Health Sciences Centre
- Royal Victoria Hospital of Barrie
- Margaret and Charles Juravinski Cancer Centre
- Cancer Centre of Southeastern Ontario at Kingston General Hospital
- London Regional Cancer Program at London Health Sciences Centre
- Trillium Health Centre - Mississauga Site
- Ottawa Hospital Regional Cancer Centre - General Campus
- Hotel Dieu Health Sciences Hospital - Niagara
- Northeastern Ontario Regional Cancer Centre
- Northwestern Ontario Regional Cancer Care at Thunder Bay Regional Health Sciences Centre
- Toronto Sunnybrook Regional Cancer Centre at Sunnybrook and Women's College Health Sciences Centre
- Princess Margaret Hospital
- St. Joseph's Health Centre - Toronto
- Humber River Regional Hospital - Weston
- Windsor Regional Cancer Centre at Windsor Regional Hospital
- Hopital Charles Lemoyne
- Maisonneuve-Rosemont Hospital
- McGill Cancer Centre at McGill University
- Hopital Du Sacre-Coeur de Montreal
- Hopital Notre- Dame du CHUM
- Hopital du Saint-Sacrement, Quebec
- Allan Blair Cancer Centre at Pasqua Hospital
- Rigshospitalet - Copenhagen University Hospital
- Vejle Sygehus
- National Cancer Institute of Egypt
- Institut Bergonie
- Institut Gustave Roussy
- National Institute of Oncology
- Centro di Riferimento Oncologico - Aviano
- Hagaziekenhuis
- Jeroen Bosch Ziekenhuis
- Medisch Centrum Alkmaar
- Ijselmeer Ziekenhuis - Zuiderzeeziekenhuis
- Meander Medisch Centrum
- St. Lucas - Andreas Ziekenhuis
- Vrije Universiteit Medisch Centrum
- Boveny Ziekenhuis
- Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
- Slotervaart Ziekenhuis
- Onze Lieve Vrouwe Gasthuis
- Academisch Medisch Centrum at University of Amsterdam
- Albert Schweitzerziekenhuis- Zwijndrecht
- Scheperziekenhuis
- Gelre Ziekenhuizen - Lokatie Lukas
- Ziekenhuis Lievensberg
- Streekziekenhuis Gooi-Noord
- Amphia Ziekenhuis - locatie Langendijk
- Amphia Ziekenhuis - locatie Molengracht
- Atrium Medical Centre - Brunssum
- Ijsselland Ziekenhuis
- Reinier de Graaf Group - Delft
- Red Cross Hospital
- Gemini Ziekenhuis
- Deventer Ziekenhuisen
- Van Weel Bethesda Ziekenhuis
- NIJ Smellinghe
- Diaconessenhuis Eindhoven
- Medisch Spectrum Twente
- St. Anna Ziekenhuis
- Beatrixziekenhuis
- Groene Hart Ziekenhuis
- University Medical Center Groningen
- Martini Ziekenhuis
- Kennemer Gasthuis - Locatie EG
- Spaarne Ziekenhuis Haarlem
- Ziekenhuis St Jansdal
- Tjongerschans Ziekenhuis
- Atrium Medical Centre - Heerlen
- Elkerliek Ziekenhuis
- Streekziekenhuis Midden-Twente
- Westfries Gasthuis
- Zweedse Rode Kruis Ziekenhuis
- Medisch Centrum Leeuwarden - Zuid
- Leiden University Medical Center
- Diaconessenhuis Leiden
- Rijnland Ziekenhuis
- Medisch Centrum Haaglanden Antoniushove
- Academisch Ziekenhuis Maastricht
- Nederlandse Hervormde Diaconessenhuisinrichting
- Sint Antonius Ziekenhuis
- Nijmegen Cancer Center at Radboud University Medical Center
- Ziekenhuis Bernhoven
- Waterlandziekenhuis
- Saint Laurentius Ziekenhuis
- Saint Franciscus Ziekenhuis
- University Medical Center Rotterdam at Erasmus Medical Center
- St. Franciscus Gasthuis
- Medisch Centrum Rynmond-Zuid - Lokatie Zuider
- Medisch Centrum Rynmond Zuid - Lokatie: Clara
- Havenziekenhiuis
- Ikazia Ziekenhuis
- Maasland Hospital
- Albert Schweitzerziekenhuis- Sliedrecht
- Ruwaard Van Putten Ziekenhuis
- Ziekenhuis Refaja
- Ziekenhuis de Honte
- Rivierenland Tiel
- St. Elisabeth Ziekenhuis
- Twee Steden Ziekenhuis Vestiging Tilburg
- University Medical Center Utrecht
- Mesos Medisch Centrum - Overvecht
- Oudenrijn Ziekenhuis
- St. Joseph Veghel
- Maxima Medisch Centrum - locatie Eindhoven
- Holy-Ziekenhuis
- Reinier de Graaf Group - Voorburg
- St. Jans Gasthuis Weert
- Hofpoort Ziekenhuis
- Zaans Medisch Centrum
- Lorentz Ziekenhuis
- 'T Lange Land Ziekenhuis
- Isala Klinieken - locatie Sophia
- Isala Klinieken - locatie Weezenlanden
- University of Auckland School of Medicine
- Christchurch Hospital
- Waikato Hospital
- Haukeland Hospital - University of Bergen
- Norwegian Radium Hospital
- St. Olavs University Hospital
- Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
- Instituto Portugues de Oncologia de Francisco Gentil - Centro Regional de Oncologia de Lisboa, S.A.
- National Cancer Institute - Bratislava
- Institute of Oncology - Ljubljana
- Mary Potter Oncology Centre
- Sandton Oncology Centre
- Medical Oncology Centre of Rosebank
- Johannesburg General Hospital
- Sahlgrenska University Hospital at Gothenburg University
- University Hospital of Linkoping
- Sunderby Hospital
- Lund University Hospital
- Orebro University Hospital
- Karolinska University Hospital - Huddinge
- Sundsvall Hospital
- Umea Universitet
- Stoke Mandeville Hospital
- Royal United Hospital
- City Hospital - Birmingham
- Birmingham Heartlands Hospital
- Blackpool Victoria Hospital
- Royal Bournemouth Hospital
- Bradford Hospitals NHS Trust
- Bristol Haematology and Oncology Centre
- Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust
- Conquest Hospital
- Kent and Canterbury Hospital
- St Helier Hospital
- Cheltenham General Hospital
- Countess of Chester Hospital
- Essex County Hospital
- Doncaster Royal Infirmary
- Russells Hall Hospital
- Royal Devon and Exeter Hospital
- Queen Elizabeth Hospital
- Diana Princess of Wales Hospital
- Royal Free and University College Medical School
- Hinchingbrooke Hospital
- King George Hospital
- Leeds General Infirmary at Leeds Teaching Hospital NHS Trust
- Leicester Royal Infirmary
- Royal Liverpool University Hospital
- Aintree University Hospital
- Saint Bartholomew's Hospital
- Guy's and St. Thomas' Hospitals NHS Foundation Trust
- St. George's Hospital
- St. Georges Hospital Medical School
- Royal Marsden NHS Foundation Trust - London
- University College Hospital
- Clatterbridge Centre for Oncology NHS Trust
- James Cook University Hospital
- Newcastle Upon Tyne Hospitals NHS Trust
- Mount Vernon Cancer Centre at Mount Vernon Hospital
- Norfolk and Norwich University Hospital
- Oxford Radcliffe Hospital
- Portsmouth Hospitals NHS Trust
- Whiston Hospital
- Royal Preston Hospital
- Berkshire Cancer Centre at Royal Berkshire Hospital
- Oldchurch Hospital
- Pembury Hospital
- Salisbury District Hospital
- Scunthorpe General Hospital
- Cancer Research Centre at Weston Park Hospital
- Southampton General Hospital
- North Staffs Royal Infirmary
- Royal Marsden NHS Foundation Trust - Surrey
- Singleton Hospital
- Taunton and Somerset Hospital
- Torbay Hospital
- Hillingdon Hospital
- Sandwell General Hospital
- Royal Hampshire County Hospital
- New Cross Hospital
- Belfast City Hospital Trust
- Western General Hospital
- Western Infirmary
- Royal Infirmary - Castle
- Southern General Hospital
- Velindre Cancer Center at Velinde Hospital
- University Hospital of Wales
- Royal Gwent Hospital
- Glan Clywd District General Hospital
- Saint Richards Hospital
- Hull Royal Infirmary
- Kettering General Hosptial
- Staffordshire General Hospital
- Great Western Hospital