Comparing Chemoprevention Approaches for School-based Malaria Control
Malaria,Falciparum, Anemia in Children
About this trial
This is an interventional prevention trial for Malaria,Falciparum focused on measuring malaria, school, chemoprevention, preventive treatment, screening and treatment, education, cognitive function, adolescent, hemoglobin
Eligibility Criteria
Inclusion Criteria:
Students (enrolled in the primary intervention)
- Currently enrolled in the study school
- Plan to attend the study school for the remainder of the school year
- Parent/guardian available to provide written informed consent Household members (enrolled in the Household Prevalence survey)
- Slept in the household for most nights in the last month
- Age 6 months or older
- For minors, parent/guardian available to provide written informed consent
Exclusion Criteria:
Students (enrolled in the primary intervention)
- Current evidence of severe malaria or danger signs
- Known adverse reaction to the study drugs
- History of cardiac problems or fainting
- Taking medications known to prolong QT
- Family history of prolonged QT
- Girls 10 years old and older with epilepsy or psoriasis Household members (enrolled in the Household Prevalence survey)
- Household with more than one school-age child enrolled in the study
- Current evidence of severe malaria or danger signs
Sites / Locations
- Kamuzu University of Health Sciences
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
No Intervention
Intermittent Screening and Treatment (IST)
Intermittent Preventive Treatment (IPT)
Control
Students will be screened for infection using a higher sensitivity malaria rapid diagnostic test and treated if positive. Treatment will be with DP (females less than 10 years old and all males) or chloroquine (females 10 years old or older).
All students are treated at each intervention. Treatment will be with DP (females less than 10 years old and all males) or chloroquine (females 10 years old or older).
Students will not receive preventive treatment.