Comparing Effects of Various Combinations of 6 Hertz(Hz) rTMS & LFrTMS on Motor Recovery Due to Cerebrovascular Disease
Cerebrovascular Disease
About this trial
This is an interventional treatment trial for Cerebrovascular Disease focused on measuring Cerebrovascular Disease, Repetitive Transcranial Magnetic Stimulation
Eligibility Criteria
Inclusion Criteria:
- Aged from 30 to 90 years;
- Newly onset cerebral infarction or brain hemorrhage confirmed by MRI or CT;
- the disease duration is less than 20 weeks when recruited into the trial;
- no existence of limb motor dysfunction before this onset, and new occurrence of unilateral limb motor dysfunction after this onset;
- the physical and mental condition are good enough to cooperate with the assessment and treatment;
- the NIHSS score: total 5-20,1a,1b,1c=0;
- the subject or legal guardian sign the consent form.
Exclusion Criteria:
- during pregnancy;
- with skull defect;
- with metal implants, cardiac pacemaker, cochlear implantation;
- epileptiform discharge in EEG.
Sites / Locations
- Beijing Hospital, National Center of GerontologyRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Active Comparator
Sham Comparator
combined rTMS at both M1
real primed LFrTMS at unaffected M1
real LFrTMS at unaffected M1
all sham stimulation
combined rTMS at both M1: sham 6 hertz(Hz) rTMS on unaffected M1 / real 1 Hz rTMS on unaffected M1 / real 6 Hz rTMS on affected M1
real primed LFrTMS at unaffected M1: real 6 hertz(Hz) rTMS on unaffected M1 / real 1 Hz rTMS on unaffected M1 / sham 6 Hz rTMS on affected M1
real LFrTMS at unaffected M1: sham 6 hertz(Hz) rTMS on unaffected M1 / real 1 Hz rTMS on unaffected M1 / sham 6 Hz rTMS on affected M1
all sham stimulation: sham 6 hertz(Hz) rTMS on unaffected M1 / sham 1 Hz rTMS on unaffected M1 /sham 6 Hz rTMS on affected M1