Comparing Injection Treatments for Tennis Elbow (CITTE)
Tennis Elbow, Lateral Epicondylitis, Elbows Tendonitis
About this trial
This is an interventional treatment trial for Tennis Elbow
Eligibility Criteria
Inclusion Criteria:
Invitations to participate in the study will be extended to male and female patients, 18 years and above, referred to the Orthopaedic Departments who receive a diagnosis of Lateral Epicondyle Tendinosis (with or without degenerative changes) with symptoms present for > 3 months, whose symptoms and clinical evaluation warrant the prescription of a peri-tendinous injection to relieve symptoms and who are competent to give informed consent.
Exclusion Criteria:
- Absence of tenderness at the lateral epicondyle.
- Congenital or traumatic bio-mechanical deformities of Elbow complex.
- Previous Corticosteroidal, Local Anaesthetic, PRP or Hyaluronic Acid injections to target elbow within the last three months.
- Known hypersensitivity to PRP, Hyaluronic acid or any excipients associated with any of the prescribed injections.
- Known contraindication to any treatments constituting normal/appropriate therapy in the view of the Consulting clinician including local infection
- Ipsilateral arm pathology severe enough to cause confusion of localised pain perception.
- Pregnant or lactating women
- Pain score less than 4/10
- Patients commenced on medication for the treatment of anxiety or depression within the last 6 weeks
- Previous involved in research in last 12 months
- Any progressive, degenerative neuromuscular disorder
Sites / Locations
- Wrightington Wigan and Leigh NHS Foundation TrustRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Sham Comparator
Group A PRP injection
Group B Ostenil Tendon
Group C control group
Platelet-Rich Plasma injection Single therapeutic injection of Platelet-Rich Plasma performed under ultrasound guidance. This group will also undergo a class-based physiotherapy intervention. This outcomes for this group will be compared to those receiving Sodium hyaluronate with mannitol (Ostenil Tendon) and those receiving the sham injection.
Sodium hyaluronate with mannitol (Ostenil Tendon) Single therapeutic injection of sodium hyaluronate with mannitol (marketed under the device name Ostenil Tendon) under ultrasound guidance. This group will also undergo a class-based physiotherapy intervention.
Subcutaneous sham injection. This group will also undergo a class-based physiotherapy intervention. The outcomes for this group will be compared to those receiving Sodium hyaluronate with mannitol (Ostenil Tendon) and to those receiving PRP injection.