Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy
Cancer Debulking, Enlarged Uterus, Fibroid Uterus
About this trial
This is an interventional supportive care trial for Cancer Debulking focused on measuring ERAS, Multi-modal anesthesia, Opioid consumption, Intrathecal, Epidural, Ileus
Eligibility Criteria
Inclusion Criteria:
- Female patients ≥18 years old
- Undergoing non-emergent exploratory laparotomy with the Gynecologic Oncology service
- No clinical or laboratory evidence of end organ failure:
If available:
- Platelets > 100 K/cumm
- Hemoglobin > 8.0 g/dl
- Serum creatinine <1.5 mg/dl
- Creatine clearance (CrCl) ≥30 based on the original Cockcroft-Gault formula adjusted for weight.
- INR <1.3 reference range
- All other lab values obtained as part of general preoperative work-up must be ≤1.5x normal laboratory value.
Exclusion Criteria:
- Patients not giving consent to participate in the study
- Unable to complete self-report pain questionnaire
- Moderate to severe kidney or liver failure per lab criteria as outlined
- Inability to hold anticoagulant medications for a safe amount of time per current ASRA guidelines
- Contraindication to lumbar puncture or epidural placement, per acute pain management service such as known coagulopathy or history of clotting disorders, history of scoliosis or lumbar fusion, infection at site of entry, or current systemic infection
- Complete bowel obstruction
- Contraindication to intravenous lidocaine
- No known pregnancy and not lactating.
- Currently septic
- Patient currently taking more than 30 MME a day preoperatively (for >30 days)
- BMI >50kg/m2
- Intolerance or contraindication to receiving non-steroidal anti-inflammatory drugs or acetaminophen
Sites / Locations
- Washington University School of MedicineRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Epidural bupivacaine with hydromorphone patient-controlled anesthesia (EPCA)
Intrathecal morphine with intraoperative lidocaine infusion
Standard of care at Washington University School of Medicine/Barnes-Jewish Hospital Day of surgery: preoperative tylenol, gabapentin, celebrex, and epidural dosing per standard protocol. Intraoperative: dexamethasone and epidural bupivacaine Day of surgery postoperative: hydromorphone PCA, toradol, ibuprofen, tylenol, epidural bupivacaine Postoperative: hydromorphone PCA, ibuprofen, oxycodone
Day or surgery: tylenol, gabapentin, celebrex, and preoperative intrathecal morphine one time injection (150mcg) Intraoperative: dexamethasone and lidocaine infusion 1 mg/kg ideal body weight Day of surgery postoperative: toradol, ibuprofen, tylenol Postoperative: ibuprofen, oxycodone, and hydromorphone prn