Back to resultsComparing the Efficacy of Symbicort® pMDI and Formoterol Turbuhaler in Reducing Exacerbations in Patients With Cronic Obstructive Pulmonary Disease (RISE)
Primary Purpose
COPD Patients
Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Symbicort
Formoterol turbohaler
Placebo for Symbicort pMDI
Placebo for Formoterol Turbohaler
Sponsored by
About this trial
This is an interventional treatment trial for COPD Patients focused on measuring COPD, turbuhaler, pMDI
Eligibility Criteria
Inclusion Criteria:
3. A current clinical diagnosis of COPD with COPD symptoms for more than 1 year, according to the GOLD guidelines.
4. Current or previous smoker with a smoking history equivalent to 10 or more pack years (1 pack year = 20 cigarettes smoked per day for 1 year).
5. Post-bronchodilator FEV1/forced vital capacity (FVC) <0.7 (70%) and FEV1 ≤70% of predicted normal (PN) value.
6. Documented use of a short-acting inhaled bronchodilator (β2-agonists or anticholinergics) as rescue medication within 6 months prior to study start.
7. A score of ≥2 on the modified medical research council (MMRC) dyspnea scale. 8. Documented history of ≥1 moderate or severe COPD exacerbation(s) that required treatment with systemic (oral, IM, IV) corticosteroids (a minimum 3 day course of an oral corticosteroid treatment or single depot corticosteroid injection), or hospitalization (defined as an inpatient stay or >24 hour stay in an observation area in the emergency department or other equivalent facility depending on the country and healthcare system) within 2-52 weeks before Visit 1 (i.e., not within the 14 days prior to Visit 1). A history of an exacerbation treated exclusively with antibiotics will not be considered adequate.
Exclusion Criteria:
- A history of asthma at or after 18 years of age.
- Subjects with significant or unstable ischemic heart disease, arrhythmia, cardiomyopathy, heart failure (including significant cor pulmonale), uncontrolled hypertension as defined by the Investigator, or any other relevant cardiovascular disorder as judged by the Investigator.
- Known homozygous alpha-1 antitrypsin deficiency.
- Any significant disease or disorder (e.g., gastrointestinal, liver, renal, neurological, musculoskeletal, endocrine, metabolic, malignant, psychiatric, major physical impairment) which, in the opinion of the Investigator, may either put the subject at risk because of participation in the study, or influence the results of the study, or the subject's ability to participate in the study.
- A history of malignancy (except basal cell carcinoma) within the past 5 years.
- Active tuberculosis, lung cancer, bronchiectasis, sarcoidosis, lung fibrosis, primary pulmonary hypertension, interstitial lung disease, or other active pulmonary diseases.
- Subjects who have needed additions or alterations to their usual maintenance or change in formulation of rescue therapy for COPD due to worsening symptoms within the 14 days prior to Visit 1 and up to Visit 3.
- CXR (frontal and lateral) with suspicion of pneumonia or other condition/abnormality that will require additional investigation/treatment, or put the subject at risk because of participation in the study.
- Risk factors for pneumonia: immune suppression (HIV, lupus) or other risk for pneumonia (e.g. neurological disorders affecting control of the upper airway, such as Parkinson's disease, myasthenia gravis, etc.).
- Pneumonia not resolved within 14 days of Visit 1.
- Moderate or severe COPD exacerbation that has not resolved within 14 days prior to Visit 1 or a moderate or severe COPD exacerbation that occurs between Visit 1 and Visit 2.
- Long-term oxygen therapy (LTOT) or nocturnal oxygen therapy required for greater than 12 hours a day.
- Subjects who are currently in the intensive rehabilitation phase or scheduled to begin new participation (intensive rehabilitation phase) in a pulmonary rehabilitation program during the study or have started a new pulmonary rehabilitation program within 60 days of Visit 1. Subjects in the maintenance phase of pulmonary rehabilitation program are not excluded.
- Treatment with oral, parenteral, or intra-articular corticosteroids within 4 weeks prior to Visit 1.
- Omalizumab or any other monoclonal or polyclonal antibody therapy taken for any reason within 6 months prior to Visit 1.
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Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
Active Comparator
Arm Label
Symbicort pMDI
Formoterol Turbuhaler
Arm Description
Symbicort pMDI, budesonide/formoterol, 160/4.5 μg x 2 actuations BID, for oral inhalation
Formoterol Turbuhaler, 4.5 μg x 2 actuations BID, for oral inhalation
Outcomes
Primary Outcome Measures
The Rate of Moderate and Severe COPD Exacerbations Defined as: Worsening of ≥2 Major Symptoms or Worsening of 1 Major Symptom Together With ≥1 Minor Symptom for ≥2 Consecutive Days
The annual COPD exacerbation rate was analyzed and compared between two arms.
Annual exacerbation rate for each subject is defined as number of exacerbations divided by duration of randomized treatment period in years.
The annual COPD exacerbation rate of Symbicort group was compared with annual rate of Formoterol group. The rate ratio of Symbicort vs. Formoteroal was assessed by a negative binomial model.
Exacerbations, that met the modified Anthonisen criteria and duration ≥2 days were classified as moderate and severe exacerbations.
Moderate exacerbation: treatment of symptoms with systemic corticosteroids (≥3 days) and/or antibiotics.
Severe exacerbation: symptoms that require hospitalization (including >24 hours in ED/urgent care setting).
Secondary Outcome Measures
Number of Patients With Moderate or Severe COPD Exacerbation.
The number of patients who developed moderate or severe COPD exacerbation during treatment period were reported. Cox proportional hazards regression model was fitted to data to compare the two treatment arms .
The hazard ratio and 95% CI were estimated.
St. George's Respiratory Questionnaire (SGRQ)
SGRQ is a standardized, self-administered tool for measuring impaired health and perceived wellbeing in respiratory diseases; a validated electronic version of the questionnaire in the relevant validated languages was used in this study.
The questionnaire contains 50 items divided into three dimensions (Symptoms, Activity and Impact).
Each of the three dimensions of the questionnaire is scored separately in the range from 0 to 100:
zero (0) score indicating no impairment of quality of life.
The total SGRQ score ranging from 0 to 100 is a summary score utilizing responses to all items calculated using weights attached to each item of the questionnaire.
Higher scores indicate poorer health and change of 4 units in the SGRQ has been determined to be the threshold for a clinically relevant change in health status.
The change from baseline was statistically summarized and compared between two arms in a mixed model.
Pre-dose/Pre-bronchodilator FEV1 at the Study Site
FEV1 from pre-dose spirometry is a measurement of lung function. The change from baseline on pre-dose FEV1 was summarized and compared between Symbicort and Formoterol groups using a mixed model.
Total Rescue Medication Use (Average Puffs/Day)
Use of rescue medication is a measure of symptoms that need to be treated with a short-acting bronchodilator.
The average daily use across the observation period was used for analysis. Change from baseline was summarized and compared between two arms using a mixed model.
Nights With Awakening Due to COPD
Nighttime awakening due to COPD symptoms correspond to the severity of nocturnal symptoms from COPD.
The average number of awakening per night over the treatment period was analyzed. It was derived as the number of night with awakening divided by the total number of nights with data in the recording period. Change from baseline period on awakening was summarized and compared between two arms using a mixed model.
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT02157935
Brief Title
Comparing the Efficacy of Symbicort® pMDI and Formoterol Turbuhaler in Reducing Exacerbations in Patients With Cronic Obstructive Pulmonary Disease
Acronym
RISE
Official Title
A Phase IIIB, 6-Month, Double-blind, Double-dummy, Randomized, Parallel-group, Multicenter Exacerbation Study of Symbicort® Pressurized Metered-Dose Inhaler (pMDI) 160/4.5 μg x 2 Actuations Twice-daily Compared to Formoterol Turbuhaler 4.5 μg x 2 Inhalations Twice-daily in Cronic Obstructive Pulmonary Disease (COPD) Patients.
Study Type
Interventional
2. Study Status
Record Verification Date
October 2017
Overall Recruitment Status
Completed
Study Start Date
June 27, 2014 (Actual)
Primary Completion Date
February 8, 2016 (Actual)
Study Completion Date
February 8, 2016 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
AstraZeneca
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
Comparing the efficacy of Symbicort® pMDI and Formoterol Turbuhaler in reducing exacerbations in patients with Chronic Obstructive Pulmonary Disease (COPD).
Detailed Description
A Phase IIIB, 6-Month, Double-blind, Double-dummy, Randomized, Parallel-group, Multicenter Exacerbation Study of Symbicort® pMDI 160/4.5 μg x 2 Actuations Twice-daily Compared to Formoterol Turbuhaler 4.5 μg x 2 Inhalations Twice-daily in COPD Patients.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
COPD Patients
Keywords
COPD, turbuhaler, pMDI
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
2026 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Symbicort pMDI
Arm Type
Active Comparator
Arm Description
Symbicort pMDI, budesonide/formoterol, 160/4.5 μg x 2 actuations BID, for oral inhalation
Arm Title
Formoterol Turbuhaler
Arm Type
Active Comparator
Arm Description
Formoterol Turbuhaler, 4.5 μg x 2 actuations BID, for oral inhalation
Intervention Type
Drug
Intervention Name(s)
Symbicort
Intervention Description
Budesonide/formoterol pMDI, 160/4.5 μg x 2 actuations BID, for oral inhalation, 120 doses
Intervention Type
Drug
Intervention Name(s)
Formoterol turbohaler
Intervention Description
Formoterol Turbuhaler 4.5 μg x 2 actuations BID, for oral inhalation, 60 doses
Intervention Type
Other
Intervention Name(s)
Placebo for Symbicort pMDI
Intervention Description
pMDI, aerosol for oral inhalation, placebo, 120 doses
Intervention Type
Other
Intervention Name(s)
Placebo for Formoterol Turbohaler
Intervention Description
PLacebo powder for oral inhalation, 60 doses
Primary Outcome Measure Information:
Title
The Rate of Moderate and Severe COPD Exacerbations Defined as: Worsening of ≥2 Major Symptoms or Worsening of 1 Major Symptom Together With ≥1 Minor Symptom for ≥2 Consecutive Days
Description
The annual COPD exacerbation rate was analyzed and compared between two arms.
Annual exacerbation rate for each subject is defined as number of exacerbations divided by duration of randomized treatment period in years.
The annual COPD exacerbation rate of Symbicort group was compared with annual rate of Formoterol group. The rate ratio of Symbicort vs. Formoteroal was assessed by a negative binomial model.
Exacerbations, that met the modified Anthonisen criteria and duration ≥2 days were classified as moderate and severe exacerbations.
Moderate exacerbation: treatment of symptoms with systemic corticosteroids (≥3 days) and/or antibiotics.
Severe exacerbation: symptoms that require hospitalization (including >24 hours in ED/urgent care setting).
Time Frame
Randomization at Week 0 to End of Treatment (EoT) W 26
Secondary Outcome Measure Information:
Title
Number of Patients With Moderate or Severe COPD Exacerbation.
Description
The number of patients who developed moderate or severe COPD exacerbation during treatment period were reported. Cox proportional hazards regression model was fitted to data to compare the two treatment arms .
The hazard ratio and 95% CI were estimated.
Time Frame
From randomzation to EoT W 26
Title
St. George's Respiratory Questionnaire (SGRQ)
Description
SGRQ is a standardized, self-administered tool for measuring impaired health and perceived wellbeing in respiratory diseases; a validated electronic version of the questionnaire in the relevant validated languages was used in this study.
The questionnaire contains 50 items divided into three dimensions (Symptoms, Activity and Impact).
Each of the three dimensions of the questionnaire is scored separately in the range from 0 to 100:
zero (0) score indicating no impairment of quality of life.
The total SGRQ score ranging from 0 to 100 is a summary score utilizing responses to all items calculated using weights attached to each item of the questionnaire.
Higher scores indicate poorer health and change of 4 units in the SGRQ has been determined to be the threshold for a clinically relevant change in health status.
The change from baseline was statistically summarized and compared between two arms in a mixed model.
Time Frame
From Run-in W -4 to EoT W 26
Title
Pre-dose/Pre-bronchodilator FEV1 at the Study Site
Description
FEV1 from pre-dose spirometry is a measurement of lung function. The change from baseline on pre-dose FEV1 was summarized and compared between Symbicort and Formoterol groups using a mixed model.
Time Frame
From Run-in W -4 to EoT W 26
Title
Total Rescue Medication Use (Average Puffs/Day)
Description
Use of rescue medication is a measure of symptoms that need to be treated with a short-acting bronchodilator.
The average daily use across the observation period was used for analysis. Change from baseline was summarized and compared between two arms using a mixed model.
Time Frame
From Run-in W -4 to EoT W 26
Title
Nights With Awakening Due to COPD
Description
Nighttime awakening due to COPD symptoms correspond to the severity of nocturnal symptoms from COPD.
The average number of awakening per night over the treatment period was analyzed. It was derived as the number of night with awakening divided by the total number of nights with data in the recording period. Change from baseline period on awakening was summarized and compared between two arms using a mixed model.
Time Frame
From Run-in W -4 to EoT W 26
10. Eligibility
Sex
All
Minimum Age & Unit of Time
40 Years
Maximum Age & Unit of Time
95 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
3. A current clinical diagnosis of COPD with COPD symptoms for more than 1 year, according to the GOLD guidelines.
4. Current or previous smoker with a smoking history equivalent to 10 or more pack years (1 pack year = 20 cigarettes smoked per day for 1 year).
5. Post-bronchodilator FEV1/forced vital capacity (FVC) <0.7 (70%) and FEV1 ≤70% of predicted normal (PN) value.
6. Documented use of a short-acting inhaled bronchodilator (β2-agonists or anticholinergics) as rescue medication within 6 months prior to study start.
7. A score of ≥2 on the modified medical research council (MMRC) dyspnea scale. 8. Documented history of ≥1 moderate or severe COPD exacerbation(s) that required treatment with systemic (oral, IM, IV) corticosteroids (a minimum 3 day course of an oral corticosteroid treatment or single depot corticosteroid injection), or hospitalization (defined as an inpatient stay or >24 hour stay in an observation area in the emergency department or other equivalent facility depending on the country and healthcare system) within 2-52 weeks before Visit 1 (i.e., not within the 14 days prior to Visit 1). A history of an exacerbation treated exclusively with antibiotics will not be considered adequate.
Exclusion Criteria:
A history of asthma at or after 18 years of age.
Subjects with significant or unstable ischemic heart disease, arrhythmia, cardiomyopathy, heart failure (including significant cor pulmonale), uncontrolled hypertension as defined by the Investigator, or any other relevant cardiovascular disorder as judged by the Investigator.
Known homozygous alpha-1 antitrypsin deficiency.
Any significant disease or disorder (e.g., gastrointestinal, liver, renal, neurological, musculoskeletal, endocrine, metabolic, malignant, psychiatric, major physical impairment) which, in the opinion of the Investigator, may either put the subject at risk because of participation in the study, or influence the results of the study, or the subject's ability to participate in the study.
A history of malignancy (except basal cell carcinoma) within the past 5 years.
Active tuberculosis, lung cancer, bronchiectasis, sarcoidosis, lung fibrosis, primary pulmonary hypertension, interstitial lung disease, or other active pulmonary diseases.
Subjects who have needed additions or alterations to their usual maintenance or change in formulation of rescue therapy for COPD due to worsening symptoms within the 14 days prior to Visit 1 and up to Visit 3.
CXR (frontal and lateral) with suspicion of pneumonia or other condition/abnormality that will require additional investigation/treatment, or put the subject at risk because of participation in the study.
Risk factors for pneumonia: immune suppression (HIV, lupus) or other risk for pneumonia (e.g. neurological disorders affecting control of the upper airway, such as Parkinson's disease, myasthenia gravis, etc.).
Pneumonia not resolved within 14 days of Visit 1.
Moderate or severe COPD exacerbation that has not resolved within 14 days prior to Visit 1 or a moderate or severe COPD exacerbation that occurs between Visit 1 and Visit 2.
Long-term oxygen therapy (LTOT) or nocturnal oxygen therapy required for greater than 12 hours a day.
Subjects who are currently in the intensive rehabilitation phase or scheduled to begin new participation (intensive rehabilitation phase) in a pulmonary rehabilitation program during the study or have started a new pulmonary rehabilitation program within 60 days of Visit 1. Subjects in the maintenance phase of pulmonary rehabilitation program are not excluded.
Treatment with oral, parenteral, or intra-articular corticosteroids within 4 weeks prior to Visit 1.
Omalizumab or any other monoclonal or polyclonal antibody therapy taken for any reason within 6 months prior to Visit 1.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Gary T Ferguson, MD
Organizational Affiliation
Pulmonary Research Insititute of Southeast Michigan
Official's Role
Principal Investigator
Facility Information:
Facility Name
Research Site
City
Andalusia
State/Province
Alabama
ZIP/Postal Code
36420
Country
United States
Facility Name
Research Site
City
Andalusia
State/Province
Alabama
Country
United States
Facility Name
Research Site
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35209
Country
United States
Facility Name
Research Site
City
Birmingham
State/Province
Alabama
Country
United States
Facility Name
Research Site
City
Foley
State/Province
Alabama
ZIP/Postal Code
36535
Country
United States
Facility Name
Research Site
City
Foley
State/Province
Alabama
Country
United States
Facility Name
Research Site
City
Jasper
State/Province
Alabama
ZIP/Postal Code
35501
Country
United States
Facility Name
Research Site
City
Jasper
State/Province
Alabama
Country
United States
Facility Name
Research Site
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
Facility Name
Research Site
City
Mobile
State/Province
Alabama
Country
United States
Facility Name
Research Site
City
Chandler
State/Province
Arizona
ZIP/Postal Code
85224
Country
United States
Facility Name
Research Site
City
Chandler
State/Province
Arizona
Country
United States
Facility Name
Research Site
City
Flagstaff
State/Province
Arizona
ZIP/Postal Code
86001
Country
United States
Facility Name
Research Site
City
Flagstaff
State/Province
Arizona
Country
United States
Facility Name
Research Site
City
Peoria
State/Province
Arizona
ZIP/Postal Code
85381
Country
United States
Facility Name
Research Site
City
Peoria
State/Province
Arizona
Country
United States
Facility Name
Research Site
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85018
Country
United States
Facility Name
Research Site
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85050
Country
United States
Facility Name
Research Site
City
Phoenix
State/Province
Arizona
Country
United States
Facility Name
Research Site
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85724
Country
United States
Facility Name
Research Site
City
Tucson
State/Province
Arizona
Country
United States
Facility Name
Research Site
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72204
Country
United States
Facility Name
Research Site
City
Little Rock
State/Province
Arkansas
Country
United States
Facility Name
Research Site
City
Fresno
State/Province
California
ZIP/Postal Code
93702
Country
United States
Facility Name
Research Site
City
Fresno
State/Province
California
Country
United States
Facility Name
Research Site
City
Fullerton
State/Province
California
ZIP/Postal Code
92835
Country
United States
Facility Name
Research Site
City
Fullerton
State/Province
California
Country
United States
Facility Name
Research Site
City
Gold River
State/Province
California
ZIP/Postal Code
95670
Country
United States
Facility Name
Research Site
City
Gold River
State/Province
California
Country
United States
Facility Name
Research Site
City
Lakewood
State/Province
California
ZIP/Postal Code
90712
Country
United States
Facility Name
Research Site
City
Lakewood
State/Province
California
Country
United States
Facility Name
Research Site
City
Los Angeles
State/Province
California
ZIP/Postal Code
90025
Country
United States
Facility Name
Research Site
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
Research Site
City
Los Angeles
State/Province
California
Country
United States
Facility Name
Research Site
City
Newport Beach
State/Province
California
ZIP/Postal Code
92663
Country
United States
Facility Name
Research Site
City
Newport Beach
State/Province
California
Country
United States
Facility Name
Research Site
City
Orange
State/Province
California
ZIP/Postal Code
92868
Country
United States
Facility Name
Research Site
City
Orange
State/Province
California
Country
United States
Facility Name
Research Site
City
Rancho Mirage
State/Province
California
ZIP/Postal Code
92270
Country
United States
Facility Name
Research Site
City
Rancho Mirage
State/Province
California
Country
United States
Facility Name
Research Site
City
San Jose
State/Province
California
ZIP/Postal Code
95117
Country
United States
Facility Name
Research Site
City
San Jose
State/Province
California
Country
United States
Facility Name
Research Site
City
Westminster
State/Province
California
ZIP/Postal Code
92683
Country
United States
Facility Name
Research Site
City
Westminster
State/Province
California
Country
United States
Facility Name
Research Site
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80014
Country
United States
Facility Name
Research Site
City
Aurora
State/Province
Colorado
Country
United States
Facility Name
Research Site
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80909
Country
United States
Facility Name
Research Site
City
Colorado Springs
State/Province
Colorado
Country
United States
Facility Name
Research Site
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
Research Site
City
Clearwater
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Coral Gables
State/Province
Florida
ZIP/Postal Code
33134
Country
United States
Facility Name
Research Site
City
Coral Gables
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33334
Country
United States
Facility Name
Research Site
City
Fort Lauderdale
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Hialeah
State/Province
Florida
ZIP/Postal Code
33013
Country
United States
Facility Name
Research Site
City
Hialeah
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Kissimmee
State/Province
Florida
ZIP/Postal Code
34741
Country
United States
Facility Name
Research Site
City
Kissimmee
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Miami
State/Province
Florida
ZIP/Postal Code
33186
Country
United States
Facility Name
Research Site
City
Miami
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Orlando
State/Province
Florida
ZIP/Postal Code
32825
Country
United States
Facility Name
Research Site
City
Orlando
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Ormond Beach
State/Province
Florida
ZIP/Postal Code
32174
Country
United States
Facility Name
Research Site
City
Ormond Beach
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Panama City
State/Province
Florida
ZIP/Postal Code
32405
Country
United States
Facility Name
Research Site
City
Panama City
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Pensacola
State/Province
Florida
ZIP/Postal Code
32503
Country
United States
Facility Name
Research Site
City
Pensacola
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Port Orange
State/Province
Florida
ZIP/Postal Code
32129
Country
United States
Facility Name
Research Site
City
Port Orange
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33710
Country
United States
Facility Name
Research Site
City
Saint Petersburg
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
Research Site
City
Sarasota
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Sebring
State/Province
Florida
ZIP/Postal Code
33870
Country
United States
Facility Name
Research Site
City
Sebring
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Winter Park
State/Province
Florida
ZIP/Postal Code
32789-4681
Country
United States
Facility Name
Research Site
City
Winter Park
State/Province
Florida
Country
United States
Facility Name
Research Site
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30331
Country
United States
Facility Name
Research Site
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30342
Country
United States
Facility Name
Research Site
City
Atlanta
State/Province
Georgia
Country
United States
Facility Name
Research Site
City
Lawrenceville
State/Province
Georgia
ZIP/Postal Code
30046
Country
United States
Facility Name
Research Site
City
Lawrenceville
State/Province
Georgia
Country
United States
Facility Name
Research Site
City
Rincon
State/Province
Georgia
ZIP/Postal Code
31326
Country
United States
Facility Name
Research Site
City
Rincon
State/Province
Georgia
Country
United States
Facility Name
Research Site
City
Stockbridge
State/Province
Georgia
ZIP/Postal Code
30281
Country
United States
Facility Name
Research Site
City
Stockbridge
State/Province
Georgia
Country
United States
Facility Name
Research Site
City
Eagle
State/Province
Idaho
ZIP/Postal Code
83616
Country
United States
Facility Name
Research Site
City
Eagle
State/Province
Idaho
Country
United States
Facility Name
Research Site
City
Nampa
State/Province
Idaho
ZIP/Postal Code
83687
Country
United States
Facility Name
Research Site
City
Nampa
State/Province
Idaho
Country
United States
Facility Name
Research Site
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60607
Country
United States
Facility Name
Research Site
City
Chicago
State/Province
Illinois
Country
United States
Facility Name
Research Site
City
Springfield
State/Province
Illinois
ZIP/Postal Code
62704
Country
United States
Facility Name
Research Site
City
Springfield
State/Province
Illinois
Country
United States
Facility Name
Research Site
City
Avon
State/Province
Indiana
ZIP/Postal Code
46123
Country
United States
Facility Name
Research Site
City
Avon
State/Province
Indiana
Country
United States
Facility Name
Research Site
City
Brownsburg
State/Province
Indiana
ZIP/Postal Code
46112
Country
United States
Facility Name
Research Site
City
Brownsburg
State/Province
Indiana
Country
United States
Facility Name
Research Site
City
Muncie
State/Province
Indiana
ZIP/Postal Code
47304
Country
United States
Facility Name
Research Site
City
Muncie
State/Province
Indiana
Country
United States
Facility Name
Research Site
City
Valparaiso
State/Province
Indiana
ZIP/Postal Code
46383
Country
United States
Facility Name
Research Site
City
Valparaiso
State/Province
Indiana
Country
United States
Facility Name
Research Site
City
Council Bluffs
State/Province
Iowa
ZIP/Postal Code
51503
Country
United States
Facility Name
Research Site
City
Council Bluffs
State/Province
Iowa
Country
United States
Facility Name
Research Site
City
Fort Mitchell
State/Province
Kentucky
ZIP/Postal Code
41017
Country
United States
Facility Name
Research Site
City
Fort Mitchell
State/Province
Kentucky
Country
United States
Facility Name
Research Site
City
Hazard
State/Province
Kentucky
ZIP/Postal Code
41701
Country
United States
Facility Name
Research Site
City
Hazard
State/Province
Kentucky
Country
United States
Facility Name
Research Site
City
Opelousas
State/Province
Louisiana
ZIP/Postal Code
70570
Country
United States
Facility Name
Research Site
City
Opelousas
State/Province
Louisiana
Country
United States
Facility Name
Research Site
City
Shreveport
State/Province
Louisiana
ZIP/Postal Code
71104
Country
United States
Facility Name
Research Site
City
Shreveport
State/Province
Louisiana
Country
United States
Facility Name
Research Site
City
Sunset
State/Province
Louisiana
ZIP/Postal Code
70584
Country
United States
Facility Name
Research Site
City
Sunset
State/Province
Louisiana
Country
United States
Facility Name
Research Site
City
Bangor
State/Province
Maine
ZIP/Postal Code
04401
Country
United States
Facility Name
Research Site
City
Bangor
State/Province
Maine
Country
United States
Facility Name
Research Site
City
Brockton
State/Province
Massachusetts
ZIP/Postal Code
02301
Country
United States
Facility Name
Research Site
City
Brockton
State/Province
Massachusetts
Country
United States
Facility Name
Research Site
City
Farmington Hills
State/Province
Michigan
ZIP/Postal Code
48336
Country
United States
Facility Name
Research Site
City
Farmington Hills
State/Province
Michigan
Country
United States
Facility Name
Research Site
City
Port Huron
State/Province
Michigan
ZIP/Postal Code
48060
Country
United States
Facility Name
Research Site
City
Port Huron
State/Province
Michigan
Country
United States
Facility Name
Research Site
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55402
Country
United States
Facility Name
Research Site
City
Minneapolis
State/Province
Minnesota
Country
United States
Facility Name
Research Site
City
Plymouth
State/Province
Minnesota
ZIP/Postal Code
55441
Country
United States
Facility Name
Research Site
City
Plymouth
State/Province
Minnesota
Country
United States
Facility Name
Research Site
City
Biloxi
State/Province
Mississippi
ZIP/Postal Code
39531
Country
United States
Facility Name
Research Site
City
Biloxi
State/Province
Mississippi
Country
United States
Facility Name
Research Site
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63141
Country
United States
Facility Name
Research Site
City
Saint Louis
State/Province
Missouri
Country
United States
Facility Name
Research Site
City
Billings
State/Province
Montana
ZIP/Postal Code
59102
Country
United States
Facility Name
Research Site
City
Billings
State/Province
Montana
Country
United States
Facility Name
Research Site
City
Bellevue
State/Province
Nebraska
ZIP/Postal Code
68005
Country
United States
Facility Name
Research Site
City
Bellevue
State/Province
Nebraska
Country
United States
Facility Name
Research Site
City
Lincoln
State/Province
Nebraska
ZIP/Postal Code
68510
Country
United States
Facility Name
Research Site
City
Lincoln
State/Province
Nebraska
Country
United States
Facility Name
Research Site
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68114
Country
United States
Facility Name
Research Site
City
Omaha
State/Province
Nebraska
Country
United States
Facility Name
Research Site
City
Marlton
State/Province
New Jersey
ZIP/Postal Code
08053
Country
United States
Facility Name
Research Site
City
Marlton
State/Province
New Jersey
Country
United States
Facility Name
Research Site
City
Summit
State/Province
New Jersey
ZIP/Postal Code
07901
Country
United States
Facility Name
Research Site
City
Summit
State/Province
New Jersey
Country
United States
Facility Name
Research Site
City
Jackson Heights
State/Province
New York
ZIP/Postal Code
11372
Country
United States
Facility Name
Research Site
City
Jackson Heights
State/Province
New York
Country
United States
Facility Name
Research Site
City
Rochester
State/Province
New York
ZIP/Postal Code
14618
Country
United States
Facility Name
Research Site
City
Rochester
State/Province
New York
Country
United States
Facility Name
Research Site
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Facility Name
Research Site
City
Charlotte
State/Province
North Carolina
Country
United States
Facility Name
Research Site
City
Cornelius
State/Province
North Carolina
ZIP/Postal Code
28031
Country
United States
Facility Name
Research Site
City
Cornelius
State/Province
North Carolina
Country
United States
Facility Name
Research Site
City
Flat Rock
State/Province
North Carolina
ZIP/Postal Code
28731
Country
United States
Facility Name
Research Site
City
Flat Rock
State/Province
North Carolina
Country
United States
Facility Name
Research Site
City
Greensboro
State/Province
North Carolina
ZIP/Postal Code
27408
Country
United States
Facility Name
Research Site
City
Greensboro
State/Province
North Carolina
Country
United States
Facility Name
Research Site
City
High Point
State/Province
North Carolina
ZIP/Postal Code
27262
Country
United States
Facility Name
Research Site
City
High Point
State/Province
North Carolina
Country
United States
Facility Name
Research Site
City
Cadiz
State/Province
Ohio
ZIP/Postal Code
43907
Country
United States
Facility Name
Research Site
City
Cadiz
State/Province
Ohio
Country
United States
Facility Name
Research Site
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45231
Country
United States
Facility Name
Research Site
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45242
Country
United States
Facility Name
Research Site
City
Cincinnati
State/Province
Ohio
Country
United States
Facility Name
Research Site
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43214
Country
United States
Facility Name
Research Site
City
Columbus
State/Province
Ohio
Country
United States
Facility Name
Research Site
City
Genoa
State/Province
Ohio
ZIP/Postal Code
43430
Country
United States
Facility Name
Research Site
City
Genoa
State/Province
Ohio
Country
United States
Facility Name
Research Site
City
Marion
State/Province
Ohio
ZIP/Postal Code
43302
Country
United States
Facility Name
Research Site
City
Marion
State/Province
Ohio
Country
United States
Facility Name
Research Site
City
Maumee
State/Province
Ohio
ZIP/Postal Code
43537
Country
United States
Facility Name
Research Site
City
Maumee
State/Province
Ohio
Country
United States
Facility Name
Research Site
City
Willoughby
State/Province
Ohio
ZIP/Postal Code
44094
Country
United States
Facility Name
Research Site
City
Willoughby
State/Province
Ohio
Country
United States
Facility Name
Research Site
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73103
Country
United States
Facility Name
Research Site
City
Oklahoma City
State/Province
Oklahoma
Country
United States
Facility Name
Research Site
City
Medford
State/Province
Oregon
ZIP/Postal Code
97504
Country
United States
Facility Name
Research Site
City
Medford
State/Province
Oregon
Country
United States
Facility Name
Research Site
City
Portland
State/Province
Oregon
ZIP/Postal Code
97202
Country
United States
Facility Name
Research Site
City
Portland
State/Province
Oregon
Country
United States
Facility Name
Research Site
City
Jefferson Hills
State/Province
Pennsylvania
ZIP/Postal Code
15025
Country
United States
Facility Name
Research Site
City
Jefferson Hills
State/Province
Pennsylvania
Country
United States
Facility Name
Research Site
City
Scottdale
State/Province
Pennsylvania
ZIP/Postal Code
15683
Country
United States
Facility Name
Research Site
City
Scottdale
State/Province
Pennsylvania
Country
United States
Facility Name
Research Site
City
Uniontown
State/Province
Pennsylvania
ZIP/Postal Code
15401
Country
United States
Facility Name
Research Site
City
Uniontown
State/Province
Pennsylvania
Country
United States
Facility Name
Research Site
City
Anderson
State/Province
South Carolina
ZIP/Postal Code
29621
Country
United States
Facility Name
Research Site
City
Anderson
State/Province
South Carolina
Country
United States
Facility Name
Research Site
City
Easley
State/Province
South Carolina
ZIP/Postal Code
29640
Country
United States
Facility Name
Research Site
City
Easley
State/Province
South Carolina
Country
United States
Facility Name
Research Site
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29615
Country
United States
Facility Name
Research Site
City
Greenville
State/Province
South Carolina
Country
United States
Facility Name
Research Site
City
Indian Land
State/Province
South Carolina
ZIP/Postal Code
29707
Country
United States
Facility Name
Research Site
City
Indian Land
State/Province
South Carolina
Country
United States
Facility Name
Research Site
City
Myrtle Beach
State/Province
South Carolina
ZIP/Postal Code
29588
Country
United States
Facility Name
Research Site
City
Myrtle Beach
State/Province
South Carolina
Country
United States
Facility Name
Research Site
City
Spartanburg
State/Province
South Carolina
ZIP/Postal Code
29303
Country
United States
Facility Name
Research Site
City
Spartanburg
State/Province
South Carolina
Country
United States
Facility Name
Research Site
City
Boerne
State/Province
Texas
ZIP/Postal Code
78006
Country
United States
Facility Name
Research Site
City
Boerne
State/Province
Texas
Country
United States
Facility Name
Research Site
City
Dallas
State/Province
Texas
ZIP/Postal Code
75225
Country
United States
Facility Name
Research Site
City
Dallas
State/Province
Texas
Country
United States
Facility Name
Research Site
City
El Paso
State/Province
Texas
ZIP/Postal Code
79903
Country
United States
Facility Name
Research Site
City
El Paso
State/Province
Texas
Country
United States
Facility Name
Research Site
City
Houston
State/Province
Texas
ZIP/Postal Code
77034
Country
United States
Facility Name
Research Site
City
Houston
State/Province
Texas
Country
United States
Facility Name
Research Site
City
McKinney
State/Province
Texas
ZIP/Postal Code
75069
Country
United States
Facility Name
Research Site
City
McKinney
State/Province
Texas
Country
United States
Facility Name
Research Site
City
Plano
State/Province
Texas
ZIP/Postal Code
75093
Country
United States
Facility Name
Research Site
City
Plano
State/Province
Texas
Country
United States
Facility Name
Research Site
City
Sealy
State/Province
Texas
ZIP/Postal Code
77474
Country
United States
Facility Name
Research Site
City
Sealy
State/Province
Texas
Country
United States
Facility Name
Research Site
City
Midvale
State/Province
Utah
ZIP/Postal Code
84047
Country
United States
Facility Name
Research Site
City
Midvale
State/Province
Utah
Country
United States
Facility Name
Research Site
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84124
Country
United States
Facility Name
Research Site
City
Salt Lake City
State/Province
Utah
Country
United States
Facility Name
Research Site
City
Herndon
State/Province
Virginia
ZIP/Postal Code
20171
Country
United States
Facility Name
Research Site
City
Herndon
State/Province
Virginia
Country
United States
Facility Name
Research Site
City
Newport News
State/Province
Virginia
ZIP/Postal Code
23606
Country
United States
Facility Name
Research Site
City
Newport News
State/Province
Virginia
Country
United States
Facility Name
Research Site
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23225
Country
United States
Facility Name
Research Site
City
Richmond
State/Province
Virginia
Country
United States
Facility Name
Research Site
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
Facility Name
Research Site
City
Tacoma
State/Province
Washington
Country
United States
Facility Name
Research Site
City
Kingwood
State/Province
West Virginia
ZIP/Postal Code
26357
Country
United States
Facility Name
Research Site
City
Kingwood
State/Province
West Virginia
Country
United States
Facility Name
Research Site
City
Caba
ZIP/Postal Code
1426
Country
Argentina
Facility Name
Research Site
City
Caba
ZIP/Postal Code
C1425BEN
Country
Argentina
Facility Name
Research Site
City
Caba
Country
Argentina
Facility Name
Research Site
City
Corrientes
ZIP/Postal Code
3400
Country
Argentina
Facility Name
Research Site
City
Corrientes
Country
Argentina
Facility Name
Research Site
City
Córdoba
ZIP/Postal Code
X5003DCE
Country
Argentina
Facility Name
Research Site
City
Córdoba
Country
Argentina
Facility Name
Research Site
City
Mendoza
ZIP/Postal Code
5500
Country
Argentina
Facility Name
Research Site
City
Mendoza
Country
Argentina
Facility Name
Research Site
City
Nueve de julio
ZIP/Postal Code
B6500EZL
Country
Argentina
Facility Name
Research Site
City
Nueve de julio
Country
Argentina
Facility Name
Research Site
City
Ranelagh
ZIP/Postal Code
1886
Country
Argentina
Facility Name
Research Site
City
Ranelagh
Country
Argentina
Facility Name
Research Site
City
San Miguel de Tucuman
ZIP/Postal Code
4000
Country
Argentina
Facility Name
Research Site
City
San Miguel de Tucuman
Country
Argentina
Facility Name
Research Site
City
Dupnitsa
ZIP/Postal Code
2600
Country
Bulgaria
Facility Name
Research Site
City
Dupnitsa
Country
Bulgaria
Facility Name
Research Site
City
Gotse Delchev
ZIP/Postal Code
2900
Country
Bulgaria
Facility Name
Research Site
City
Gotse Delchev
Country
Bulgaria
Facility Name
Research Site
City
Kozloduy
ZIP/Postal Code
3320
Country
Bulgaria
Facility Name
Research Site
City
Kozloduy
Country
Bulgaria
Facility Name
Research Site
City
Pazardzhik
ZIP/Postal Code
4400
Country
Bulgaria
Facility Name
Research Site
City
Pazardzhik
Country
Bulgaria
Facility Name
Research Site
City
Sandanski
ZIP/Postal Code
2800
Country
Bulgaria
Facility Name
Research Site
City
Sandanski
Country
Bulgaria
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1404
Country
Bulgaria
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1407
Country
Bulgaria
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1606
Country
Bulgaria
Facility Name
Research Site
City
Sofia
ZIP/Postal Code
1618
Country
Bulgaria
Facility Name
Research Site
City
Sofia
Country
Bulgaria
Facility Name
Research Site
City
Stara Zagora
ZIP/Postal Code
6000
Country
Bulgaria
Facility Name
Research Site
City
Stara Zagora
ZIP/Postal Code
6003
Country
Bulgaria
Facility Name
Research Site
City
Stara Zagora
Country
Bulgaria
Facility Name
Research Site
City
Varna
ZIP/Postal Code
9000
Country
Bulgaria
Facility Name
Research Site
City
Varna
ZIP/Postal Code
9010
Country
Bulgaria
Facility Name
Research Site
City
Varna
Country
Bulgaria
Facility Name
Research Site
City
Veliko Tarnovo
ZIP/Postal Code
5000
Country
Bulgaria
Facility Name
Research Site
City
Veliko Tarnovo
Country
Bulgaria
Facility Name
Research Site
City
Velingrad
ZIP/Postal Code
4600
Country
Bulgaria
Facility Name
Research Site
City
Velingrad
Country
Bulgaria
Facility Name
Research Site
City
Santiago
ZIP/Postal Code
7500698
Country
Chile
Facility Name
Research Site
City
Santiago
ZIP/Postal Code
8380456
Country
Chile
Facility Name
Research Site
City
Santiago
ZIP/Postal Code
8910131
Country
Chile
Facility Name
Research Site
City
Santiago
Country
Chile
Facility Name
Research Site
City
Beroun
ZIP/Postal Code
266 00
Country
Czechia
Facility Name
Research Site
City
Beroun
Country
Czechia
Facility Name
Research Site
City
Brandys nad Labem
ZIP/Postal Code
250 01
Country
Czechia
Facility Name
Research Site
City
Brandys nad Labem
Country
Czechia
Facility Name
Research Site
City
Krnov
ZIP/Postal Code
794 01
Country
Czechia
Facility Name
Research Site
City
Krnov
Country
Czechia
Facility Name
Research Site
City
Liberec
ZIP/Postal Code
460 01
Country
Czechia
Facility Name
Research Site
City
Liberec
Country
Czechia
Facility Name
Research Site
City
Ostrava-Poruba
ZIP/Postal Code
708 68
Country
Czechia
Facility Name
Research Site
City
Ostrava-Poruba
Country
Czechia
Facility Name
Research Site
City
Ostrava
ZIP/Postal Code
728 80
Country
Czechia
Facility Name
Research Site
City
Ostrava
Country
Czechia
Facility Name
Research Site
City
Praha 10
ZIP/Postal Code
108 00
Country
Czechia
Facility Name
Research Site
City
Praha 10
Country
Czechia
Facility Name
Research Site
City
Praha 5
ZIP/Postal Code
150 00
Country
Czechia
Facility Name
Research Site
City
Praha 5
ZIP/Postal Code
158 00
Country
Czechia
Facility Name
Research Site
City
Praha 5
Country
Czechia
Facility Name
Research Site
City
Praha 6
ZIP/Postal Code
163 00
Country
Czechia
Facility Name
Research Site
City
Praha 6
Country
Czechia
Facility Name
Research Site
City
Strakonice
ZIP/Postal Code
38601
Country
Czechia
Facility Name
Research Site
City
Strakonice
Country
Czechia
Facility Name
Research Site
City
Zatec
ZIP/Postal Code
43801
Country
Czechia
Facility Name
Research Site
City
Zatec
Country
Czechia
Facility Name
Research Site
City
Aschaffenburg
ZIP/Postal Code
63739
Country
Germany
Facility Name
Research Site
City
Aschaffenburg
Country
Germany
Facility Name
Research Site
City
Bad Lippspringe
ZIP/Postal Code
33175
Country
Germany
Facility Name
Research Site
City
Bad Lippspringe
Country
Germany
Facility Name
Research Site
City
Berlin
ZIP/Postal Code
10119
Country
Germany
Facility Name
Research Site
City
Berlin
ZIP/Postal Code
10787
Country
Germany
Facility Name
Research Site
City
Berlin
ZIP/Postal Code
13187
Country
Germany
Facility Name
Research Site
City
Berlin
Country
Germany
Facility Name
Research Site
City
Hannover
ZIP/Postal Code
30173
Country
Germany
Facility Name
Research Site
City
Hannover
Country
Germany
Facility Name
Research Site
City
Koblenz
ZIP/Postal Code
56068
Country
Germany
Facility Name
Research Site
City
Koblenz
Country
Germany
Facility Name
Research Site
City
Köln
ZIP/Postal Code
51069
Country
Germany
Facility Name
Research Site
City
Köln
Country
Germany
Facility Name
Research Site
City
Leipzig
ZIP/Postal Code
04207
Country
Germany
Facility Name
Research Site
City
Leipzig
ZIP/Postal Code
04275
Country
Germany
Facility Name
Research Site
City
Leipzig
Country
Germany
Facility Name
Research Site
City
Magdeburg
ZIP/Postal Code
39120
Country
Germany
Facility Name
Research Site
City
Magdeburg
Country
Germany
Facility Name
Research Site
City
Guadalajara
ZIP/Postal Code
44200
Country
Mexico
Facility Name
Research Site
City
Guadalajara
ZIP/Postal Code
44670
Country
Mexico
Facility Name
Research Site
City
Guadalajara
Country
Mexico
Facility Name
Research Site
City
Mexico
ZIP/Postal Code
14050
Country
Mexico
Facility Name
Research Site
City
Mexico
Country
Mexico
Facility Name
Research Site
City
Monterrey
ZIP/Postal Code
64460
Country
Mexico
Facility Name
Research Site
City
Monterrey
Country
Mexico
Facility Name
Research Site
City
San Juan del Rio
ZIP/Postal Code
76800
Country
Mexico
Facility Name
Research Site
City
San Juan del Rio
Country
Mexico
Facility Name
Research Site
City
Sonora
ZIP/Postal Code
83000
Country
Mexico
Facility Name
Research Site
City
Sonora
Country
Mexico
Facility Name
Research Site
City
Aleksandrów Łódzki
ZIP/Postal Code
95-070
Country
Poland
Facility Name
Research Site
City
Aleksandrów Łódzki
Country
Poland
Facility Name
Research Site
City
Białystok
ZIP/Postal Code
15-003
Country
Poland
Facility Name
Research Site
City
Białystok
ZIP/Postal Code
15-430
Country
Poland
Facility Name
Research Site
City
Białystok
Country
Poland
Facility Name
Research Site
City
Bielsk Podlaski
ZIP/Postal Code
17-100
Country
Poland
Facility Name
Research Site
City
Bielsk Podlaski
Country
Poland
Facility Name
Research Site
City
Bydgoszcz
ZIP/Postal Code
85-231
Country
Poland
Facility Name
Research Site
City
Bydgoszcz
Country
Poland
Facility Name
Research Site
City
Kościan
ZIP/Postal Code
64-000
Country
Poland
Facility Name
Research Site
City
Kościan
Country
Poland
Facility Name
Research Site
City
Kraków
ZIP/Postal Code
31-209
Country
Poland
Facility Name
Research Site
City
Kraków
Country
Poland
Facility Name
Research Site
City
Lublin
ZIP/Postal Code
20-709
Country
Poland
Facility Name
Research Site
City
Lublin
Country
Poland
Facility Name
Research Site
City
Ostrowiec Świętokrzyski
ZIP/Postal Code
27-400
Country
Poland
Facility Name
Research Site
City
Ostrowiec Świętokrzyski
Country
Poland
Facility Name
Research Site
City
Pila
ZIP/Postal Code
64-920
Country
Poland
Facility Name
Research Site
City
Pila
Country
Poland
Facility Name
Research Site
City
Poznań
ZIP/Postal Code
60-685
Country
Poland
Facility Name
Research Site
City
Poznań
Country
Poland
Facility Name
Research Site
City
Rzeszów
ZIP/Postal Code
35-205
Country
Poland
Facility Name
Research Site
City
Rzeszów
Country
Poland
Facility Name
Research Site
City
Skarżysko-Kamienna
ZIP/Postal Code
26-110
Country
Poland
Facility Name
Research Site
City
Skarżysko-Kamienna
Country
Poland
Facility Name
Research Site
City
Turek
ZIP/Postal Code
62-700
Country
Poland
Facility Name
Research Site
City
Turek
Country
Poland
Facility Name
Research Site
City
Zabrze
ZIP/Postal Code
41-800
Country
Poland
Facility Name
Research Site
City
Zabrze
Country
Poland
Facility Name
Research Site
City
Żnin
ZIP/Postal Code
88-400
Country
Poland
Facility Name
Research Site
City
Żnin
Country
Poland
Facility Name
Research Site
City
San Juan
ZIP/Postal Code
00927
Country
Puerto Rico
Facility Name
Research Site
City
San Juan
Country
Puerto Rico
Facility Name
Research Site
City
Amanzimtoti
ZIP/Postal Code
4126
Country
South Africa
Facility Name
Research Site
City
Amanzimtoti
Country
South Africa
Facility Name
Research Site
City
Cape Town
ZIP/Postal Code
1730
Country
South Africa
Facility Name
Research Site
City
Cape Town
ZIP/Postal Code
7700
Country
South Africa
Facility Name
Research Site
City
Cape Town
ZIP/Postal Code
7764
Country
South Africa
Facility Name
Research Site
City
Cape Town
Country
South Africa
Facility Name
Research Site
City
Durban
ZIP/Postal Code
4001
Country
South Africa
Facility Name
Research Site
City
Durban
ZIP/Postal Code
4301
Country
South Africa
Facility Name
Research Site
City
Durban
Country
South Africa
Facility Name
Research Site
City
Gauteng
ZIP/Postal Code
2193
Country
South Africa
Facility Name
Research Site
City
Gauteng
Country
South Africa
Facility Name
Research Site
City
Badalona(Barcelona)
ZIP/Postal Code
08916
Country
Spain
Facility Name
Research Site
City
Badalona(Barcelona)
Country
Spain
Facility Name
Research Site
City
Barcelona
ZIP/Postal Code
08003
Country
Spain
Facility Name
Research Site
City
Barcelona
Country
Spain
Facility Name
Research Site
City
Loja (Granada)
ZIP/Postal Code
18300
Country
Spain
Facility Name
Research Site
City
Loja (Granada)
Country
Spain
Facility Name
Research Site
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
Facility Name
Research Site
City
Zaragoza
Country
Spain
12. IPD Sharing Statement
Links:
URL
http://filehosting.pharmacm.com/DownloadService.ashx?client=CTR_MED_7111&studyid=2887&filename=Symbicort_RISE_Revised_CSP_3_4_FINAL_Redacted.pdf
Description
Symbicort RISE Revised CSP 3 4 FINAL Redacted
Learn more about this trial
Comparing the Efficacy of Symbicort® pMDI and Formoterol Turbuhaler in Reducing Exacerbations in Patients With Cronic Obstructive Pulmonary Disease
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