Comparison Between Hyperoncotic and Isooncotic Albumin to Support Blood Loss Replacement (VASCALB)
Blood Loss, Surgical, Fluid Retention
About this trial
This is an interventional treatment trial for Blood Loss, Surgical focused on measuring hyperoncotic, isooncotic, albumin 20%, albumin 5%, ringer lactate, blood loss, hemorrhage, fluid replacement, intravascular effect, volume expansion, cystectomy, pro-ANP, pro-BNP, glycocalyx proteins, microcirculation damages, endothelial shedding, CD138/syndecan 1, heparan sulfate, hyaluronic acid
Eligibility Criteria
Inclusion Criteria:
- Non emergent radical cystectomy with urinary diversion
- Adult: older than 18 years
- Written informed consent
Exclusion Criteria:
- Contraindications to the class of drugs under study (i.e: known hypersensitivity/ allergy to class of drugs or to the investigational product).
- Renal insufficiency: GFR: <60ml/min/1.73m2 (KDIGO Clinical Practice Guideline for Acute Kidney Injury, stage 3 and over).
- History of heart failure.
- Use of diuretic treatment.
- Women who are pregnant or breast feeding (exclusion of surgery per se).
- Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant.
- Enrolment of the investigator, his/her family members, employees and other dependent persons.
Sites / Locations
- Patrick Wuethrich, Department of Anaesthesiology and Pain Therapy, University Hospital Bern Inselspital Bern
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Active Comparator
Albumin 20%
Albumin 5%
Ringer-lactate
3mL/kg (ideal body weight) completed by a Ringer-lactate crystalloid ratio 1:1 to total amount of blood loss during removal of the bladder (i.e. the bleeding part) of cystectomy procedures.
12ml/kg (ideal body weight) completed by a Ringer-lactate crystalloid ratio 1:1 to total amount of blood loss during removal of the bladder (i.e. the bleeding part) of cystectomy procedures.
Ratio 3:1 of total of blood loss during removal of the bladder (i.e. the bleeding part) of cystectomy procedures.