Comparison of Breathing Pattern During Neurally Adjusted Ventilatory Assist Ventilation and Pressure Support Ventilation
Respiratory System Abnormalities
About this trial
This is an interventional basic science trial for Respiratory System Abnormalities focused on measuring Breathing Pattern, Mechanical Ventilation, Pressure support ventilation, Neurally Adjusted Ventilatory Assist
Eligibility Criteria
Inclusion Criteria:
- Age > 18 years
- Healthy Subject without any chronic disease
Exclusion Criteria:
- Absence of consent
- Pregnant
Sites / Locations
- Hopital Raymond Poincare
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Pressure Support Ventilator
NAVA
Gold standard partial ventilator support: Pressure Support Ventilation performed with Servo-i® ventilator (MAQUET,Critical Care, Sweden). During pressure support the inspiratory muscles are assisted by a constant inspiratory pressure adjusted by the prescriptor and applied to the airway by either an invasive or a non invasive interface. Then the subject initiate the inspiratory effort and a constant pressure is delivered to the airway in order to assist inspiration. Three levels of pressure will be tested (5 cmH2O, 8 cmH2O and 12 cmH2O)
Spontaneous Breathing using Neurally Adjusted Ventilatory Assist with trigger adjusted on diaphragmatic electromyogram. Electrical activity of the diaphragm will be obtained through a naso-gastric tube with multiple array of electrodes placed at its distal end (Eadi catheter® , Maquet Critical Care, Sweden). During NAVA the inspiratory muscles are assisted by a pressure which is proportional to this electrical activity. Then the subject initiate the inspiratory effort and a pressure proportional to the integrated EMG activity is delivered to the airway in order to assist inspiration. The adjustment of the level of NAVA (expressed in cmH2O/microvolt) will be adjusted in order to obtain a peak pressure similar to pressure support (5 cmH2O, 8 cmH2O and 12 cmH2O)