Comparison of Three Different Initial Treatments Without Protease Inhibitors for HIV Infection
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring HIV-1, Didanosine, Drug Therapy, Combination, Zidovudine, Nevirapine, Stavudine, Lamivudine, RNA, Viral, Reverse Transcriptase Inhibitors, Anti-HIV Agents, Viral Load, Combivir, BMS 232632, Efavirenz, Treatment Naive
Eligibility Criteria
Inclusion Criteria Patients may be eligible for this study if they: Are HIV-positive. Have a viral load of at least 400 copies/ml within 90 days prior to study entry. Are at least 16 years old. Weigh at least 40 kg. Have a negative pregnancy test within 48 hours before starting study drugs, if female and able to have children. Agree to use 2 effective methods of birth control while taking, and for 3 months after stopping, the study medications. Provide written consent of a parent or guardian, if under 18 years of age. Exclusion Criteria Patients will not be eligible for this study if they: Have taken anti-HIV drugs in the past. Are allergic to any of the study drugs or ingredients. Are pregnant or breast-feeding. Have taken any of the following drugs within 14 days prior to study entry: amiodarone, astemizole, bepridil, cisapride, ergot or ergot derivatives, systemic itraconazole, systemic ketoconazole, midazolam, propoxyphene, quinidine, rifampin, terfenadine, thalidomide, triazolam, or St. John's wort. Have taken drugs that influence the immune system, HIV or other vaccines, or investigational drugs within 30 days prior to study entry. Prednisone at a dose of 10 mg or less daily is allowed. Have taken drugs or been hospitalized for serious infections or medical illnesses within 14 days prior to study entry. Have growths or tumors that require drug therapy. Have Pneumocystis carinii pneumonia that is not clinically stable and whose treatment is not completed at least 7 days prior to study entry. Have infections or medical illnesses that are not under control or that have not received complete treatment before study entry. Have any condition that, in the opinion of the investigator, would prevent them from properly participating in the study. Abuse drugs or alcohol. This study has been updated to exclude patients who are receiving systemic itraconazole and rifabutin.
Sites / Locations
- Alabama Therapeutics CRS
- USC CRS
- UCLA CARE Center CRS
- Stanford CRS
- UC Davis Medical Center
- Univ. of California Davis Med. Ctr., ACTU
- Ucsd, Avrc Crs
- Ucsf Aids Crs
- Santa Clara Valley Med. Ctr.
- San Mateo County AIDS Program
- Willow Clinic A0507 CRS
- Harbor-UCLA Med. Ctr. CRS
- University of Colorado Hospital CRS
- Georgetown University CRS (GU CRS)
- Univ. of Miami AIDS CRS
- The Ponce de Leon Ctr. CRS
- Univ. of Hawaii at Manoa, Leahi Hosp.
- Northwestern University CRS
- Rush Univ. Med. Ctr. ACTG CRS
- Cook County Hosp. CORE Ctr.
- Indiana Univ. School of Medicine, Infectious Disease Research Clinic
- Indiana Univ. School of Medicine, Wishard Memorial
- Methodist Hosp. of Indiana
- Univ. of Iowa Healthcare, Div. of Infectious Diseases
- Johns Hopkins Adult AIDS CRS
- Massachusetts General Hospital ACTG CRS
- Bmc Actg Crs
- Beth Israel Deaconess Med. Ctr., ACTG CRS
- Brigham and Women's Hosp. ACTG CRS
- SSTAR, Family Healthcare Ctr.
- University of Minnesota, ACTU
- St. Louis ConnectCare, Infectious Diseases Clinic
- Washington U CRS
- Univ. of Nebraska Med. Ctr., Durham Outpatient Ctr.
- SUNY - Buffalo, Erie County Medical Ctr.
- Beth Israel Med. Ctr., ACTU
- Weill Med. College of Cornell Univ., The Cornell CTU
- NY Univ. HIV/AIDS CRS
- Cornell CRS
- Columbia Univ., HIV Prevention and Treatment Medical Ctr.
- HIV Prevention & Treatment CRS
- Univ. of Rochester ACTG CRS
- AIDS Care CRS
- McCree McCuller Wellness Ctr. at the Connection, Infectious Disease Unit
- Unc Aids Crs
- Duke Univ. Med. Ctr. Adult CRS
- Regional Center for Infectious Disease, Wendover Medical Center CRS
- Univ. of Cincinnati CRS
- Case CRS
- MetroHealth CRS
- The Ohio State Univ. AIDS CRS
- Philadelphia Veterans Admin. Med. Ctr. A6205 CRS
- Univ. of Pennsylvania Health System, Presbyterian Med. Ctr.
- Hosp. of the Univ. of Pennsylvania CRS
- Pitt CRS
- The Miriam Hosp. ACTG CRS
- Rhode Island Hosp.
- Vanderbilt Therapeutics CRS
- University of Washington AIDS CRS
- Puerto Rico-AIDS CRS