Comparison of Tofacitinib and Prednisolone in the Treatment of Active Takayasu's Arteritis (TOFGCTAK)

Inclusion Criteria: Patients aged between 18-65 years old; Fulfilled the classification criteria of Takayasu's arteritis by ACR 1990; Active TAK: defined by the definition of active disease in the recommendations released by EULAR in 2018 or Kerr's criteria by NIH; Patients who signed the informed consent form. Exclusion Criteria: Patients who failed or intolerant to either tofacitinib or its similar drugs; Patients with severe liver disease defined by the serum ALT or AST elevated more than 2 times the upper limits; Not well controlled diabetes; Moderate and severe hyperlipedimia; Patients with history of thrombus; Uncontrolled heart failure od renal dysfunction (eGFR <30ml/min); Patients with active infection, including tuberculosis, hepatitis B and C, HIV infection, bacterial or fungal infection; Upper GI bleeding happened in 3 months before enrollment; Refractory hypertension; Pregnant or intended to be pregnant recently; Severe coronary artery involvement demonstrated by CTA; Severe cranial or cervical or renal artery diseases that need surgery; Patients that should not be included judged by the investigator.