Comparison of Voice Therapy and Antireflex Therapy in LPR
Laryngopharyngeal Reflux
About this trial
This is an interventional treatment trial for Laryngopharyngeal Reflux
Eligibility Criteria
Inclusion Criteria:
- 18 years of age and older
- Hoarseness
- Reflux symptom index score >13
- Reflux finding score >7
- English speaking
Exclusion Criteria:
- Evidence of other laryngeal pathology
- Esophageal dysmotility
- Gastroesophageal reflux
- Currently on anti-reflux medications
- Presence of a neurologic condition
- Active smoking
- Currently pregnant
- Individuals unable to consent for themselves
- Recent upper respiratory infection lasting more than 1 month
- Prior treatment for laryngopharyngeal reflux.
Sites / Locations
- Temple Otolaryngology
- Temple University Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Experimental
Voice therapy
Antireflux medication
Voice therapy and Anti-reflux therapy
Evaluation is completed over two, one-hour sessions. Once the evaluation is complete, the subject will begin weekly, individual voice therapy for 55 minute sessions per week with a second year graduate student under the direct supervision of the clinical faculty member.Treatment sessions will include a counseling component and an active exercise program.
Intervention includes treatment with one of the following: Omeprazole- Dose range oral, 20mg once a day, up to 40mg twice a day Lansoprazole-Dose range 15mg per day- 30mg twice a day Esomeprazole- Dose range oral, 20mg once a day, up to 40mg twice a day Rantidine-Dose range: 150 mg twice a day or 300 mg once a day. Rantidine may be used in combination with any of the above
Subjects will receive both anti-reflux medication as detailed above and voice therapy as detailed above.