Continuation Electroconvulsive Therapy (C-ECT) for Relapse Prevention in Major Depression
Depression
About this trial
This is an interventional prevention trial for Depression focused on measuring Consolidation ECT, Pharmacotherapy, Efficacy, Depression, Prevention, Electroconvulsive therapy, Drug therapy
Eligibility Criteria
Inclusion Criteria:
- MDD diagnosis by DSM IV-TR.
- ECT requirement during acute episode. Therapeutic indication will be based on clinical criteria, following APA guidelines. During the acute episode, patients will be controlled by the usual clinical care team.
- Complete clinical remission (HDRS < or = 7 across two weeks).
- Appropriate intellectual level that allows adequate communication.
- Women of childbearing potential must use contraceptive methods.
- Signed Consent form.
- Other axis I or II diagnosis by DSM-IV-TR, except for nicotine dependence.
- To be in maintenance ECT program.
- To receive ECT during the previous three months of the acute episode.
- Pregnancy or breastfeeding.
Exclusion Criteria:
- Other axis I or II diagnosis by DSM-IV-TR, except for nicotine dependence.
- To be in maintenance ECT program.
- To receive ECT during the previous three months of the acute episode.
- Pregnancy or breastfeeding.
Sites / Locations
- Hospital Universitari de Bellvitge
- Corporació Sanitària Parc Tauli
- Hospital Universitari de Bellvitge, IDIBELL
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
C-ECT and Pharmacotherapy
Pharmacotherapy
Consolidation treatment with ECT will be considered finished after 9 months of being started, at which time patients will stay only on the pharmacological treatment they already had. The study will be completed within 15 months of patient inclusion (six months after the end of C-ECT). Patient assessment and follow-up will be conducted by participant researchers. Blind rater will conduct clinical and adverse effects ratings. A neuropsychologist will conduct neuropsychological assessments.
Pharmacotherapy will remain unchanged since the acute episode to the end of the study. Psychotropics will be obtained as usually from the National Health System and will be prescribed according to data sheet.