Continuous TAP Blocks: Relative Effects of a Basal Infusion vs. Repeated Bolus Doses
Postoperative Pain
About this trial
This is an interventional treatment trial for Postoperative Pain focused on measuring Healthy Human Volunteers
Eligibility Criteria
Inclusion Criteria:
- healthy volunteers weighing more than 45 kg;
- must be willing to have bilateral transverses abdominis plane nerve block catheters be placed with subsequent ropivacaine administration and sensory testing for 6 hours
Exclusion Criteria:
- BMI greater than 40 (BMI=weight in kg/ [height in meters];
- regular opioid use within the previous 2 months;
- previous participation within the same study;
- allergy to study medications;
- known renal insufficiency (creatinine > 1.5 mg/dL);
- pregnancy;
- incarceration; and
- any known neuro-muscular deficit of either abdominal wall.
Sites / Locations
- Ucsd Ctri
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
RIGHT side BOLUS and left side basal
RIGHT side BASAL and left side bolus
Bilateral transversus abdominis catheters were inserted and ropivacaine 0.2% administered concurrently. For the right catheter, the ropivacaine was administered as two separate bolus doses of 24 mL each: one at time point zero and one 3 hours later. For the left catheter, the ropivacaine was administered as a continuous basal infusion (8 mL/h) from time point zero for the following 6 hours
Bilateral transversus abdominis catheters were inserted and ropivacaine 0.2% administered concurrently. For the right catheter, the ropivacaine was administered as a continuous basal infusion (8 mL/h) from time point zero for the following 6 hours. For the left catheter, the ropivacaine was administered as two separate bolus doses of 24 mL each: one at time point zero and one 3 hours later