Control of Epidemic Influenza Through a School-based Influenza Vaccination Program (CEI)
Influenza
About this trial
This is an interventional prevention trial for Influenza focused on measuring influenza vaccine, live attenuated influenza vaccine (LAIV or FluMist), inactivated influenza vaccine (IIV), School-based influenza vaccination program, children, herd protection
Eligibility Criteria
Inclusion Criteria: signed informed consent form by adult participant or parent/ legal guardian who are able to understand and comply with the protocol and assent when appropriate (usually age greater than or equal to 7 years) healthy subject, 4 through 18 years of age and none of the exclusion criteria Exclusion Criteria: history of hypersensitivity, especially anaphylactic reaction, to any components of FluMist™, including eggs or egg products on aspirin therapy or aspirin-containing therapy history of Guillain-Barré syndrome known or suspected immune deficiency diseases such as combined immunodeficiency, agammaglobulinemia, and thymic abnormalities and conditions such as human immunodeficiency virus infection, malignancy, leukemia or lymphoma on immunosuppressive therapies such as systemic corticosteroids, alkylating drugs, antimetabolites, or radiation close contact within 21 days after vaccination with immunocompromised individuals history of asthma or reactive airway disease history of chronic or underlying diseases for which the licensed inactivated flu vaccine (IIV-T) is recommended such as chronic disorders of the cardiovascular and pulmonary systems, or chronic conditions such as metabolic diseases, renal dysfunction or hemoglobinopathies that required medical follow-up or hospitalization during the preceding year concurrent use with an anti-influenza compound pregnant or plans to become pregnant within 42 days after vaccination nursing mother and any condition which, in the opinion of the investigator, interferes with evaluation of the vaccine
Sites / Locations
- Scott & White Hospital and Clinic
- Scott & White Hospital and Clinic
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Intervention Cities
Comparison Cities
Children 4 years of age and older in the intervention cites (Temple, Belton, Academy, Troy, Salado, Rogers, and Holland) with be offered live attenuated or inactivated influenza vaccines through a school-based research vaccination program.
Children living in the comparison cities (Waco, Bryan and College Station) which are within 90 miles of the intervention cites will received their influenza vaccines (live attenuated or inactivated influenza vaccines) by the local healthcare providers.