Coronary Artery Calcium and Cardiovascular Risk Factors Analysis After RT or Breast Cancer (RadioTherapy)
Breast Cancer
About this trial
This is an interventional screening trial for Breast Cancer focused on measuring Breast cancer, Coronary Artery Disease, Calcium Score, Radiotherapy, Cardiovascular events, CV risk factors, Cardio-oncology
Eligibility Criteria
Inclusion Criteria: Women diagnosed with early-stage breast cancer treated with adjuvant whole breast external beam radiotherapy from 2010 to 2017; Patients with a > 5 years clinical follow-up (FU) from diagnosis of breast cancer Adult women/patients ≥18 years old and ≤ 60 years at time of radiation therapy; Patients with homogeneous and standardized radiation exposure protocol (external beam radiotherapy 40 Gy in 15 fractions) Patients who have signed the written informed consent Exclusion Criteria: Patients aged < 18 or > 60 years at time of radiation therapy; Patients with bilateral breast cancer or breast cancer of unknown laterality; Patients with a prior diagnosis of invasive cancer (apart from non-melanoma skin cancer); Patients with known active ischemic heart disease during or before the RT period; Patients with no definitive surgery (e.g. a biopsy only); Patients who did not receive radiotherapy were excluded from the Study. Patients who are currently participating in an investigational interventional study. IORT (Intraoperative radiotherapy) and PBI (partial breast radiotherapy) excluded Participants not suitable for participation, whatever the reason, as judged by the Investigator, including medical or clinical conditions, or participants potentially at risk of noncompliance to Study procedures
Sites / Locations
- IRCCS Centro Cardiologico MonzinoRecruiting
Arms of the Study
Arm 1
Other
Single arm study
After signing the informed consent form, patients who meet all eligibility criteria will be enrolled in the Study. After execution of the CT scan the patient will be contacted to discuss the CT scan result. In case of high calcium score values, patients will be performing a cardiological medical examination, ECG, and further diagnostic investigations, as clinically indicated