Coronary Artery Revascularization in Diabetes (VA CARDS)
Coronary Artery Disease
About this trial
This is an interventional treatment trial for Coronary Artery Disease focused on measuring CABG, Coronary Disease, Diabetes, PCI
Eligibility Criteria
Inclusion Criteria: Patients with diabetes with severe coronary artery disease General Inclusion Criteria Age at least 18 years old Patients with either Type I or Type II diabetes with a documented HbA1c greater than site ULN (If not on diabetic medication must be confirmed by a blood glucose of >126 mg/dL fasting, or >200mg/dL non-fasting); OR on diabetic medication with a documented physician diagnosis of diabetes mellitus. No child bearing potential (if female) Patient competent to provide consent Exclusion Criteria: General Exclusion Criteria Congenital heart disease Coronary bypass surgery within the preceding one year Need for concomitant cardiac surgery AHA Class III decompensated heart failure or AHA Class IV heart failure Undergoing PCI for hemodynamic instability related to acute STEMI History of a hemorrhagic stroke Severe bleeding diathesis History of chronic pancreatitis A severe co-morbid condition that is expected to limit life to less than two years Embolic stroke in the past six months Significant GI bleed within the last one month Lack of adequate surgical conduit Sensitivity to clopidogrel (Plavix) Sensitivity to glycoprotein IIb/IIIa inhibitors Chronic systemic steroid use Participation in another trial with active intervention Patient unable to be adequately followed
Sites / Locations
- VA Medical Center, Birmingham
- Southern Arizona VA Health Care System, Tucson
- VA Palo Alto Health Care System
- VA San Diego Healthcare System, San Diego
- VA Medical Center, San Francisco
- VA Greater Los Angeles HCS, Sepulveda
- VA Eastern Colorado Health Care System, Denver
- VA Medical Center, DC
- VA Medical Center, Miami
- James A. Haley Veterans Hospital, Tampa
- Atlanta VA Medical and Rehab Center, Decatur
- Richard Roudebush VA Medical Center, Indianapolis
- VA Boston Healthcare System, Brockton Campus
- VA Medical Center, Minneapolis
- New York Harbor HCS
- VA Medical Center, Asheville
- VA Medical Center, Durham
- VA Medical Center, Cleveland
- VA Medical Center, Oklahoma City
- Ralph H Johnson VA Medical Center, Charleston
- VA Medical Center, Memphis
- VA North Texas Health Care System, Dallas
- Michael E. DeBakey VA Medical Center (152)
- VA South Texas Health Care System, San Antonio
- VA Puget Sound Health Care System, Seattle
- Zablocki VA Medical Center, Milwaukee
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
PCI
CABG
Percutaneous coronary intervention
Coronary artery bypass graft (CABG)